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RheumNow Podcast – Combination Biologics

d Jack Cush, MD

Dr. Jack Cush serves up this week's news and articles from RheumNow.com.

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Planes, Trains and COVID Distancing

d Jack Cush, MD

MMWR reports the risk of acquiring an infection with SARS-CoV-2 is reduced 23% to 57% when the middle seat was vacant (compared with full aircraft occupancy).

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Autoimmune Risk of Death Up during COVID

d Jack Cush, MD

A population-based study in the UK shows that patients with rare autoimmune rheumatic diseases (RAIRD) were 44% more likely to die during the 2020 COVID-19 pandemic (March - April) compared to either the general population or their pre-COVID risk.

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USPSTF - No Need to Screen for Vitamin D Deficiency

d Jack Cush, MD

JAMA has published the new recommendation from the US Preventive Services Task Force (USPSTF) stating that screening for vitamin D deficiency is unnecessary and unwarranted in asymptomatic adults.

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NICE Guidelines on Chronic Pain Management

d Jack Cush, MD

In the United Kingdom, where it is estimated that chronic pain affects one‑third to one‑half of the population, NICE (National Institute for Health and Care Excellence) has recently released an updated guideline on the management of chronic pain for people aged 16 years and over.

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ASSAIL-MI trial studied 200 pt with new (<6hr) STEMI-randomized to either PBO or IV 280 mg tocilizumab. While no signif difference in final infarct size (7.2 vs 9.1%; P=.08), TCZ treated pts had better myocardial salvage & less Microvascular obstruction https://t.co/WRRGXCbP5O

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Non-Hallmark manifestations of dermatomyositis include: panniculitis, diffuse subcutaneous edema, erythroderma, calcinosis, ulceration, flagellate erythema, Wong-type DM, gingival telangiectasias, and the ovoid palatal patch (full read) https://t.co/x6cdP3WDcW

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News Feature: NICE Guidelines on Chronic Pain Management Chronic primary pain is pain with no clear underlying cause, or pain (or its impact) that is out of proportion to any observable injury or disease. https://t.co/DV24wKBlEc https://t.co/8uxx4NC9W1

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"Don't check antibodies post vaccination! Most lab assays test anti-nucleocapsid antibodies from the virus and not the antibodies to the spike protein. Also we do not have data at what antibody level is protective or not protective. - Dr. J Curtis #RNL2021 @RADoctor "

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Smoking and RA are closely related. 50% of establish RA pts higher rate of smoking Smoking cessation - lowers RA disease activity #RNL2021

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Study of 2,842 participants in Osteoarthritis Initiative shows that a Western diet is associated with an increased risk of knee OA (HR =1.69), while a more prudent diet reduced risk of knee OA (HR = 0.70). 30% risk is mediated by high BMI https://t.co/24Dbwy9eJ5

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News Feature: Sinusitis Activity Linked to Brain Dysfunction Have you wondered why fibromyalgia, fatigue or cognitive dysfunction often co-associate with chronic sinusitis? https://t.co/Ow993w5Jb9 https://t.co/mYYDkDuJTv

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Calcinosis is associated with these autoantibodies - NXP-2, anti-PM/SCL and MDA-5 https://t.co/ORA2y1BWgn

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“Send a photo with the skin biopsy” - advice to rheumatologists by a dermatopathologist to help with path interpretation. #RNL2021 Great #RNL2021 notes from Dr. Kathryn Dao @KDAO2011

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Can Multiple Sclerosis and RA Coexist? What Drugs can be used? https://t.co/PYFQI7vn3M https://t.co/UQplGREDjf

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News Feature: IL-23 Targeting for Enthesitis in Psoriatic Arthritis Treatment with guselkumab (Tremfya) was effective in resolving enthesitis among patients with psoriatic arthritis (PsA), a post-hoc analysis of two phase III trials found. https://t.co/a6ypaa6Zxb https://t.co/zdRpZWIPAt

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#RNL2021 notes from Dr. Rachel Tate ( @uptoTate ) Clinical pearl: Bisphosphonates can cause posterior iritis (consider this in patients with negative labs and long term use of bisphosphonates.) Dr. Wang #RheumNow

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Artificial intelligence study shows neural networks can be trained to detect radiographic sacroiliitis on pelvic Xrays and achieve expert-level detection of definite radiographic sacroiliitis & could improve diagnostic accuracy at non-specialised sites https://t.co/oLNzWjHjrw

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News Feature: Low Risk of Malignancy with Secukinumab Analysis of ongoing safety from the SEC drug development program shows a low risk for malignancy in SEC patients treated for up to five years for either psoriasis, PsA or AS. https://t.co/tf1lWa03tF https://t.co/Ad1fOJZv4c

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In millions with hand OA, the thumb base (CMC1) is the most affected joint. metanalysis of 16 studies shows Xray CMC1 OA is more prevalent in females and is strongly associated with age. https://t.co/mNeXbWHdwa

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