All News

FDA2.jpg

FDA Warning on NSAIDs in Pregnancy

d FDA

The U.S. Food and Drug Administration announced today in a Drug Safety Communication that it is requiring labeling changes for nonsteroidal anti-inflammatory drugs (NSAIDs).

Read Article
podcast logo

RheumNow Podcast – Good Time Charlie…. (10.16.20)

d Jack Cush, MD

Dr. Jack Cush sings the news and journal reports from the past week on RheumNow.com.

Read Article
UPA ABA box

Abatacept vs. Upadacitinib in Biologic Refractory Rheumatoid Arthritis

d Jack Cush, MD

NEJM reports the results of the SELECT-Choice trial, a head to head study of upadacitinib (UPA) and abatacept (ABA) in biologic refractory rheumatoid arthritis (RA); 12 weeks results showed UPA was significantly more clinically effective than ABA using a DAS28-CRP remission, but ABA had fewer safety signals and serious adverse events.

Read Article
Cancer.risk_.jpg

ICI Arthritis Tied to Cancer Progression

d

Cancer patients treated with immune checkpoint inhibitors (ICI) who develop severe arthritis may be at risk for progression of the malignancy, a single-center study suggested.

Read Article
URI.infection.COrona.jpg

COVID Transmission from Young to Old

d Jack Cush, MD

The CDC has analyzed temporal trends in percent positivity by age group in COVID-19 hotspot counties before and after their identification as hotspots.

Read Article
DVT.PE_.Blood_.jpg

Tofacitinib and Thromboembolic Risk

d Jack Cush, MD

Mease and colleagues have reviewed the tofacitinib drug development and clinical trial data, finding the risk of venous (VTE) and arterial thromboembolism (ATE) to be low and augmented in patients with baseline cardiovascular abd VTE risk factors and those taking higher doses of tofacitinib (10 m

Read Article
Clot.DVT_.VTE_.blood_.jpg

Thrombotic Risk in Rheumatoid Arthritis Linked to Disease Activity

d Jack Cush, MD

A large RA cohort study from the Swedish Rheumatology Quality Register shows a higher risk of venous thromboembolism (VTE) in rheumatoid arthritis (RA)  and that risk is linked to RA disease activity. 

Read Article
QD Clinics - Vignette Lessons from Rheum Clinic - Compilation on No Shows, Delays in SpA Dx, & when patients bail out on DMARD therapy. Listen on iTunes https://t.co/FHJv01AAbC on on Android> https://t.co/i8icH8AS9m

Links:

Dr. John Cush RheumNow ( View Tweet)

Pre Print of UK research suggests biomarkers for Severe COVID-19 includes markers of myeloid or endothelial activation; such as D-dimer, EN-RAGE, CXCL10, GM-CSF, IL-6, TNF-α, IL-2, GDF-15, G-CSF, S100A12, https://t.co/Yv6yM4DYmp

Links:

Dr. John Cush RheumNow ( View Tweet)

259 SLE patients followed an 80% were in lupus low disease activity state (LLDAS); 82% in remission; 19% w/ active dz. 56 pst in subjective Low activity (SLQ<6) compared to SLAQ>6, latter had more arthritis, fibromyalgia and took steroids https://t.co/IdeSNlaEOG

Links:

Dr. John Cush RheumNow ( View Tweet)

Juvenile localized scleroderma was Rx w/ MTX or MMF (in MTX refractory) and compared retrospectively. Facial linear scler. more likely in MTX pts and MMF pts had pansclerotic morphea or mixed subtype. Outcomes were same at 9.4 yrs: inactive in 100% & 91% https://t.co/2X9SpqeLwx

Links:

Dr. John Cush RheumNow ( View Tweet)

EUSTAR study of ILD in systemic sclerosis: 826 pts with SSc-ILD finds 27% with progressive ILD (mod-severe FVC decline >5-10%) over 12 mos. Predictive factors for FVC decline over 5 yrs were male sex, higher mRSS skin score and reflux/dysphagia symptoms. https://t.co/lLd2FrMIkx

Links:

Dr. John Cush RheumNow ( View Tweet)

@MattieRheumMD @News_CRA @statnews People are being crushed by co-pays- rheumatology patients' co-pays doubled to $1000 last year - and medical staff are wasting much time on paperwork. Plus, the @Aetna @CVSHealth merger caused prior auth meltdown in many. (Intentional?) Rebate system must go! ASK STAKEHOLDERS.

Angus Worthing MD AngusWorthing ( View Tweet)

There have been many cases of Kawasaki vasculitis in kids ith COVID-19; now Lg vessel vasculitis in 79 yo Japanese man w/ COVID-19 pneumonia, CRP 17.7 mg/dL, spiking fevers and CTA and FDG-PET evid of aortic and LVV, neg ANCA, nl IgG4, but was HLA-DR4+. https://t.co/UpL4Z1qK2p

Links:

Dr. John Cush RheumNow ( View Tweet)

Observational study of 123 Spanish rheumatic dz pts w/ COVID-19, finds 54 hospitalized. Admitted pts were 69.7 yrs, and 22% died. Admission was assoc w/ older age, autoimmune dz (vs inflammatory arthritis; OR: 3.55), but not DMARD Rx. https://t.co/UWNyhOKbvF

Links:

Dr. John Cush RheumNow ( View Tweet)

In elderly AAV, initial steroid dose should be rapidly reduced be required to safe outcomes. Study of 179 AAV pts 80yrs old w/ high Birmingham Vasculitis Score 16.1. 94% MPO+, 6% PR3+, Serious infections seen in high-dose Pred vs low dose (43% vs. 22%) https://t.co/mZbtKvPUIX

Links:

Dr. John Cush RheumNow ( View Tweet)

Studies of inflammasome generated kinase activity (using UCN-01-mediated inflammasome activation) shown to discriminate familial Meditteranean fever patients from healthy donors and other inflammatory disorders https://t.co/euThYpSQMx

Links:

Dr. John Cush RheumNow ( View Tweet)

Study of 196 RA pts shows lung Dz common by chest CT, regardless of serostatus. RA lung=higher mortality (HR of 5.3). RA lung dz found in 28%; 16% had ILD, 14% bronchiectasis, 9.5% w pleural dz. RA lung dz in both seropositive (29%) & seronegative (28%) https://t.co/upNX7cvlWq

Links:

Dr. John Cush RheumNow ( View Tweet)

Study of 5792 RA pts from 11 RCTs compared ACR Boolean remission with (4V) or without Pt Global scores (3V) using Xray & functional outcomes. 3V (TJC28, SJC28, CRP CRP mg/dL<=1) was as validi as 4V-remission in predicting Xray, less so functional, outcomes https://t.co/r1azrh3SHS

Links:

Dr. John Cush RheumNow ( View Tweet)

Nonradiographic axial spondyloarthritis= meeting axSpA criteria without Xray sacroiliitis. Swiss study compared women & men w nr-axSpA. Women had a longer Dx delay, higher Dz activity & enthesitis, less B27+ & signif lower TNFi resp rate (OR 0.19) vs Men https://t.co/ykAHfimOd5

Links:

Dr. John Cush RheumNow ( View Tweet)

Do you get our email newsletter?

Looking for the latest rheumatology news & trends? Sign up for the RheumNow weekday newsletter:

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Rheumnow.com is a news source dedicated to the field of Rheumatology. It is written by experts in the field, and written for rheumatologists and individuals working in related fields. Rheumnow.com provides daily updates on the site and in your inbox when you are signed up for our newsletter.

Copyright 2024 All Rights Reserved.

×