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Taking CAR-T for a Test Drive

Michael Putman, MD, MSCI Nov 17, 2024

When the ACR Convergence 2024 abstract site went live, the first query I typed into the search bar was, “CAR-T.” I consider myself a CAR-T skeptic and would be surprised if the magical results from this NEJM case series replicate at scale, but it seems likely that CAR-T will revolutionize the care for (some) patients with rheumatic diseases. What new data will be presented at ACR?

Article

Are Emulation Trials a Fantasy?

Janet Pope, MD, MPH, FRCPC Nov 17, 2024

Are emulation ‘trials’ helpful, despite the biases that occur with observational data, or do they truly mimic the results of randomized controlled trials (RCTs)?

@ACRheumDC Check out the ACR policy position statements Created by volunteer-led, non-partisan group of GAC committee - changes based on the needs of the ACR members @cdowneymd https://t.co/oAFfYUct4y @RheumNow #ACR24 https://t.co/MmVd8XYs0j

If you are not at the table, you are on the menu https://t.co/c4anIn3aue @cdowneymd @ACRheumDC Join a committee RheumPAC Write a letter Write a post card at ACR Hub at #ACR24 Advocacy office hours with ACR staff #Act4Arthritis & Advocacy 101 on Cap Hill @RheumNow https://t.co/bpilydxEpB

@LennMcD @ACRheumDC Current congress (118th) - very tight margins, paralyzed by the ‘24 elections. Now in lame duck Many ACR policies made into bills - PA, step rx, copay accumulator, workforce, loan repayment, incr Rx transparency Needs to be passed into law @RheumNow #ACR24 https://t.co/1elEUiUAmh

https://x.com/ericdeinmd/status/1858153751158132967/photo/1

@DrLauraCoates presented Sex differences in clinical presentations of PsA: -Women present >polyarthritis, enthesitis and worse PROs which translates to ⬆️ DAPSAs in spite of less Rx progression. -Men more oligoarthritis, axial involvement, higher skin disease. #ACR24… https://t.co/iapZF0nZWX https://t.co/jZ79WfxZwh

@LennMcD @ACRheumDC Many ACR priorities in bills, needs to be passed in law Victories: Incr NIH biomedical research funding, added to DoD funds Medicare reimbursem and telehealth needs addressed by lame duck congress Get involved, reach out, write letters @RheumNow #ACR24 https://t.co/7oCvUFWpx4

"We look forward to Carol Langfords upcoming leadership at ACR and its newfound focus on ANCA vasculitis as the most important disease" 😆😂 -Phil Seo #ACR24 @RheumNow

Starting soon: Room 152A ⁦@ACRheumDC⁩ ⁦@cdowneymd⁩ ⁦@BelindaBirnbaum⁩ What does the election and current political changes mean for rheumatology? How does ACR play a role in supporting you? What are the easy steps you can do? #ACR24 ⁦@RheumNow⁩ https://t.co/jTtk80RdqI

https://x.com/ericdeinmd/status/1858145616481624161/photo/1

Thrilled to have my abstract accepted for poster presentation at #ACR24 with @rheumarhyme Drop by abs1314 to know more 🤓 #HPEd #educator #telerheumatology @Rheumnow https://t.co/j2rZLGm7lA

https://x.com/RHEUMarampa/status/1858147854298091564/photo/1

Managing DMARDs in pregnancy. Curbside consults by Lisa Sammaritano @RheumNow #ACR24 https://t.co/FQrLNz4yCz

https://x.com/synovialjoints/status/1857881212393533685/photo/1

RheumNow’s expanded coverage of the #ACR24 annual meeting is sponsored in part by Novartis. All content is chosen by RheumNow & its faculty.

In the @ACRheum MSK Ultrasound Guidance: In difficult-to-treat RA, MSUS can distinguish symptoms of active synovitis from other sources of pain. (consensus: mod) CURRENTLY do you often use ultrasound when RA gets difficult to treat, and synovitis isn't obvious? #ACR24 @RheumNow

Phase 2 DBRCT of daxdilimab, an immunoglobulin-like transcript 7 to target plasmacytoid dendritic cells No difference in primary outcome... but kiiiinda looks like something there? I dislike Phase 2's; should go straight to Phase 3 if able #ACR24 @rheumnow Abstr#1542 https://t.co/osDWDskfnA

@KDAO2011 help me out here; what is the point of analyses like this? NO difference in PROs comparing voclo vs plbo... ...but if you split by responder status its different Prescribing the drug doesn't help PROs, but when it works it works? 🤔 #ACR @RheumNow Abstr#1538 https://t.co/339drHwUuK

https://x.com/EBRheum/status/1858034836423766179/photo/1

Remote monitoring SHOULD increasingly be part of our care. BUT I don't think it neccessarily will. Just like with conferences reverting to non-virtual when facilitating virtual is logical from a learning perspective. There are other limiting interests in play #ACR24 @RheumNow https://t.co/UN3jGa7jVZ

https://twitter.com/Stiddyo/status/1857882347988988353

One situation I've seen MSK ultrasound have impact ++ in the real-world is showing patients their own RA disease activity. Arthritis might be the invisible disease sometimes, but seeing it in full Doppler colour on screen means a lot to many. #ACR24 MSK USS Guidance @RheumNow https://t.co/wd9s6FAfp4

https://x.com/drdavidliew/status/1858080136891146538/photo/1

A framework for critical conversations with patients (because the big decisions deserve high quality counselling, otherwise the consequences are real) #ACR24 16S17 @RheumNow https://t.co/fiwYY1DuMq

https://x.com/drdavidliew/status/1858094982676054297/photo/1

"Do not fear RPF." - John Stone Retroperitoneal fibrosis certainly feels challenging at times, and radiologic features might stay even after functional improvement but we've come a long way (although, despite B cell depletion, there's plenty more to do) #ACR24 16S26 @RheumNow https://t.co/2Y3buXrAFY

https://x.com/drdavidliew/status/1858117129003999631/photo/1

The @ACRheum RA outcome measures toolkit has all the relevant tools for measuring outcomes in rheumatoid arthritis (and exactly how to do it). https://t.co/GZ7tZ6fNMK Great for all US rheumatologists, but also very handy for all of us globally #ACR24 16S30 @JYazdany @RheumNow https://t.co/MSHA353MKR

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Taking CAR-T for a Test Drive

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