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#HCQ assoc. w/ ↓platelet activity & ↑vascular health in #SLE:
- 132 patients, 108 on HCQ
- Ex-vivo expts show ↓platelet aggregation & downregulation of platelet functional pathways
- HCQ may improve vascular health in SLE
Abs#0870 #ACR20 @RheumNow
https://t.co/ST9n2HGyhM
Mrinalini Dey DrMiniDey ( View Tweet)
CZP tx in axSpA pts showed significant reduction of 82% in the AAU flare rate and MSK symptoms over 96 week C-VIEW trial. #ABS0881 #ACR20 @RheumNow https://t.co/bNFHXbKEuF https://t.co/3Z232vKGPC
Dr. Rachel Tate uptoTate ( View Tweet)
In this study of RA pts w/ b/tsDMARDs tx, continuous decrease in RF titers was assoc'd w/ radiographic remission. Other factors were dse duration<5yrs, pred<5mg/d & time-integrated DAS28ESR. @RheumNow #ACR20 abs0754 https://t.co/u0pgAsK4UX
sheila RHEUMarampa ( View Tweet)
Important to tailor our approach based on patient preferences, and this abstract shows that geriatric patients have different desires for care! #ACR20 @RheumNow https://t.co/pY3VTeURSS
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Most ignore pharmacists annoying faxes re safety of QT interval with #hydroxycholoroquine likely the right thing to do! @RheumNow #ACR2020 @CRASCRRheum abstr#431. https://t.co/pXBIDOV2MP
Janet Pope Janetbirdope ( View Tweet)
SKIPPAIN trial: SEC showed rapid and significant improvement of spinal pain (primary endpt) and ⬇ disease activity in axSpA @RheumNow #ACR20 abs0899 #ACRbest https://t.co/fKSEjwd6i9
sheila RHEUMarampa ( View Tweet)
Anti-PAD Abs seen in 1/3 of pts at-risk for RA and 1/3 of pts w/ CSA.
Implications? Possible predictive value of anti-PAD Abs in RA dse progression?
@RheumNow #ACR20 abs0761 #ACRbest https://t.co/VpkjwU2YZm
sheila RHEUMarampa ( View Tweet)
Data from MUSE & TULIP trials of #anifrolumab in #SLE show increased risk of #herpeszoster when compared to placebo. Most HZ events mild-moderate, cutaneous and resolved without discontinuation of drug.
#RheumTwitter #lupus
Abs#0849 #ACR20 @RheumNow
https://t.co/8a6OcZmOso
Mrinalini Dey DrMiniDey ( View Tweet)
The development of biologics started with diphtheria- history of Medicine! Look how far we have come now prescribing over 50 different types of biologics! @RheumNow #acr20 https://t.co/XbygK5g7ON
alexa meara lexmeara ( View Tweet)
BKZ tx improved BASDAI total and single question scores related to fatigue and neck, back and hip pain in pts with PsA. #ABS0906 #ACR20 @RheumNow https://t.co/GzpJfkwvL5 https://t.co/KnJAqAKlqq
Dr. Rachel Tate uptoTate ( View Tweet)
Do pts with RA take their meds & can adherence intervention work? Yes & No. Pts starting new bDMARD RCT of electronic monitoring feedback vs usual care, adherence>80%. Neg RCT Maybe chronic users with poor adherence is group to study abstr#0799 #ACR2020 @RheumNow https://t.co/FyWoBjYnvs
Janet Pope Janetbirdope ( View Tweet)
Valerio et al find 40% of 294 patients w/ #rheumaticdisease refuse or are uncertain about getting inactivated #influenza #vaccine. Key determinants of #vaccinehesitancy found to be concerns about adverse events, safety & efficacy.
Abs#0632 #ACR20 @RheumNow
https://t.co/f34DAc5WiN
Mrinalini Dey DrMiniDey ( View Tweet)
Do you consistently address T2T in your axSpA patients in your clinical practice? List your measures below! #ACR20 @RheumNow
Dr. Rachel Tate uptoTate ( View Tweet)
Which Adalimumab biosimilar to use (if any)? The race is on to have 1st Ada or 2nd reimbursed/preferentially listed in US reimbursement plans & dare I say it mandatory switching like in Europe. Abstr#0798 #ACR2020 compares Abrilada & Humira in RA @RheumNow @CRASCRRheum https://t.co/AUcVZnc6Gj
Janet Pope Janetbirdope ( View Tweet)
In the search for biomarkers in PsA, interesting study showing absolute lymphocyte count is negatively correlated with cardiovascular disease risk score and red cell distribution width and increases with TNF-Inhibitor Therapy @rheumnow #ACR20 Abstr#878
Dr. Antoni Chan synovialjoints ( View Tweet)
Some great abstracts on #vaccine hesitancy in the #infection in #rheumaticdiseases poster session!
What's the greatest concern for patients offered #influenza & #pneumococcal vaccines?
How can we address these concerns & encourage vaccine uptake? Comment below!
#ACR20 @RheumNow
Mrinalini Dey DrMiniDey ( View Tweet)
T2T in clinical practice: Most axSpA pts had ≥1 annual ASDAS recorded, but target ID/LDA achieved in only 1/3 of pts at the first measurement. How do you address T2T in your practice? #ABS0879 #ACR20 @RheumNow https://t.co/Jy0mmqpHAb https://t.co/06fI10V3OZ
Dr. Rachel Tate uptoTate ( View Tweet)
Great job by @Rheumnow's Dr. Jonathan Kay on CT-P17, ADA biosimilar in Abst#0800. Similar ACR20 83% rate for ADA and CT-P17 with similar safety profile. #ACR20.
Eric Dein ejdein1 ( View Tweet)
Lots at #ACR20 on arthralgias w/ +CCP. Abst#760 shows bone erosions (BE) rare in these pts (4%), did not show higher risk of progression to IA (41% w BE vs 31% wo BE, p=0.4). Overall high progression, unclear if high enough # with BE for analysis. @RheumNow.
Eric Dein ejdein1 ( View Tweet)
Tracking CRP in the hyper-acute phase of admission for #COVID19 predictive of progression to critical illness- suggests trends of inflammatory biomarkers, not absolute admission values, may be most useful for triage & therapy.
Abs#0626 #ACR20 @RheumNow
https://t.co/E14y3e4ALi
Mrinalini Dey DrMiniDey ( View Tweet)