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Have you heard of pSpA? (Peripheral) pSpA: distinct clinical phenotype w/ intermediate features between pure PsA & pure axSpA but w/ a higher disease burden compared to both diseases, & lower use of b-DMARDs. Abs 1787 #ACR21 #ACRbest #RheumNow @RheumNow https://t.co/Wsysm7A0Y3 https://t.co/rwQ8ukBEDq

What Is Peripheral SpondyloArthritis? Identifying Disease Phenotype and Burden:…

Genes for oral aphthous ulcers common in gen pop’n, Behcets and w auto inflammatory PFAPA - kids w fevers ⬆️IL12 Kastner practical gene stories @RheumNow #ACR21 9T119. Have a listen. Bench to bedside & back https://t.co/UkPzoYbBNb

ARIAA Study - Abatacept Reverses ACPA+ Subclinical Arthritis: Dr. Jack Cush discusses abstract #0455, a preclinical RA intervention trial - abatacept or placebo given to at risk individuals (arthralgias, CCP+, MRI+) for 6 months, presented at #ACR21. https://t.co/fz1hPTleMn https://t.co/V4PsPZ0ZwF

https://bit.ly/3o2XwC2

5 yr multinational PROOF study - enrolled 1612 axSpA pts enrolled (65% xray+ axSpA; 35% nr-axSpA) nraxSpA had more enthesitis, PSO IBD. Over time, more TNFi use (less NSAIDs) w/ less disease activity #ACR21 Abst #0363 https://t.co/5DdDlCjq9h (Graph: NSAID use over time) https://t.co/5JE69vTIy9

https://bit.ly/2Ytz18g

Quick plug: not all joint pain in ICI-treated pts needs reflex steroids eg OA can get exacerbated by ICI Rx (ICI-aOA) call rheum, hold the PNL & save tumor response @ReidMDMPH @got_rheum @lovetolearn27 +me #ACR21 ABST1518 @RheumNow our paper @jitcancer https://t.co/InespbOn6m https://t.co/HSjtGrwePE

https://jitc.bmj.com/content/9/9/e003260

Glory to GLORIA trial? Low dose prednisone 2mg in active RA>65yrs, N=451 All Standard care. in 2yrs, ~40% drop out- same in each grp Better RA control but NNH 9.5 w steroids, mostly non severe infections. So, prednisone debate in RA continues #ACR21 @RheumNow #ACRBest abst#1678 https://t.co/emOaYSjYAa

Pregnant pts w/ PsA, but not AxSpA, at increased risk of pre-eclampsia. In RA pregnancies, pre-eclampsia risk increases w/ dz severity prior/during pregnancy. We need to discuss potential risks w/ pts and OB team. Abs 1722 #ACR21 #RheumNow @RheumNow https://t.co/yeQmNAZ1jV https://t.co/cBfeVKQHfr

Risk of Pre-eclampsia and Impact of Disease Activity and Anti-rheumatic Treatme…

Just worthwhile remembering: in terms of TNFi anti-drug immunogenicity in autoimmune disease: RA is top of the pops (although dose spacing is worse) data from NOR-DRUM A, TDM in infliximab #ACR21 ABST1525 @RheumNow https://t.co/wfcA72wcLP https://t.co/mHppH6qYdY

https://meet.acrconvergence.org/meetings/virtual/nanQoptmXdF2qGxPi

ANA negative SLE! Lunch w/Dr. John P Atkinson. When I was in training @WUSTLrheum he bet that if you come across a case of ANA neg- SLE that is convincing, he will buy lunch. Great case of SLE following spont coronary artery dissection. #ThievesMarket #ACR21 Abst#TM18 @rheumnow https://t.co/TRyQaJ4kbR

Fun things at #ACR21. Abs1186 #Kardashian index: K-index = # of followers on Twitter/expected # of followers based on citations. ⭐️Only 1 program director (PD) had K-index>5, an "academic Kardashian" ⭐️Only 11 PDs on Twitter had >100 followers https://t.co/uH408ri5nY @Rheumnow https://t.co/d8VeyzAIcU

https://bit.ly/30bgxKw

Impressive case of vasculitis – should be part of @ACRheum image bank #ThievesMarket #ACR21 Abst#TM20 @rheumnow https://t.co/YiBikROuzb

They are the up and coming leaders in our field! I got to interview them about 👉🏼why #GeriRheum is important (our pts are aging) 👉🏼small changes to your practice for big outcomes 👉🏼Tips: pain control/funx #acr21 @UnaMakris @RheumNow https://t.co/f71L0P3foE via @YouTube

Geriatric Rheumatology: Improving care of aging patients - YouTube

Pirfenidone in RA-ILD, TRAIL-1 study. Long-awaited. Early termination due to COVID led to under-powering. Slowed decline in FVC, especially in UIP pattern. Seemed to have less adverse events than we see with nintedanib. Abstr#L10 #ACR21 @RheumNow https://t.co/sYRDhG3u4y

Artificial neural network showed good generalizability and a high specificity with acceptable sensitivity in the detection of radiographic sacroiliitis. A tool for interpretation of sacroiliac radiographs as a part of the diagnostic approach @RheumNow #ACR21 Abst#1919 #ACRbest https://t.co/SdmomEWwya

New dimensions in cellular immunology. Great session, some which I understood. Kids with #JIA have more cytolytic pathway missense - some leads to macrophage activation syndrome #MAS Low NK cells in Juvenile Dermatomyositis. 9T112 #ACR21 @RheumNow https://t.co/5lUkqr65UM

Adipokines in RA ⚡️Highest Quartile Adiponectin associated w/ ⬆️ all-cause mortality HR 1.46 ⬆️ CV mortality HR 1.85 ⚡️Highest Quartile Leptine ⬆️ 25% all-cause mortality #ACR21 #Abst1645 @RheumNow https://t.co/O1NAbfMvif https://t.co/VVdgZHP1j5

https://bit.ly/3D05NNx

No clear excess risk for offspring exposed in-utero to, VED or TNFi's. UST showed infection signal BUT w/ wide CIs. We need more research re: biologics and placental transmission potential/subsequent risks. Abs 1713 #ACR21 #RheumNow #ACRbest @RheumNow https://t.co/W3K5uDyHlC

Risk of Serious Infections in Offspring Exposed in Utero to Ustekinumab or Vedo…

b/tsDMARDs + tumor response in rheum irAEs Excellent point by @CCalabreseDO @LCalabreseDO: - despite progression in 5/10, DMARD contribution uncertain (bad cancer) - without DMARD, ICI would have had to stop crucial question, prospective study needed #ACR21 ABST1519 @RheumNow https://t.co/omJnTNVscH

The wave of the future? Study details immune profile which discriminates PsA from PsO using phenotyping of serum immune cell subsets & machine learning. Abs 1774 #ACR21 #RheumNow #ACRbest @RheumNow https://t.co/huNTY3IdRf https://t.co/3aW64pb9UW

Blood-based Immune Profiling Combined with Machine Learning Discriminates Psori…

Great case where the #COVIDvaccine was blamed, but he had a diet of doughnuts, steak&cheese sandwiches w/snack cakes, and popsicles. #ThievesMarket #ACR21 @rheumnow https://t.co/J78Nw5NhKs

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