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ICYMI: The Nine Lives of Hydroxychloroquine (Updated)

d Martin J. Bergman, MD

Hydroxychloroquine is one of many medications frequently used in rheumatology practice. Its remarkable versatility is attested by its routine use in lupus, in patients with an autoimmune coagulopathy, in patients with rheumatoid arthritis, as well as in those with a low-level inflammatory arthropathy.

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ICYMI: Outcomes of Critically-Ill COVID Patients in NYC

d Jack Cush, MD

Lancet has reported COVID outcomes from NewYork-Presbyterian hospitals in NYC during March 2020 showing high rates of hospitalization, ICU admission, mechanical ventilation and death. 

A prospective observational cohort study 2 2 NYC hospitals from March 2 to April 1, 2020, looking at laboratory-confirmed COVID-19 and were critically ill with acute hypoxaemic respiratory failure, and collected clinical, biomarker, and treatment data. The primary outcome was in-hospital death.

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RheumNow Podcast – Gout Guidelines (7.3.20)

d Jack Cush, MD

Dr Jack Cush reviews the journal reports and news from RheumNow this past week. Highlights include:

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2020 ACR Gout Management Guideline

d Jack Cush, MD

In May, the American College of Rheumatology (ACR) released the"2020 Guideline for the Management of Gout"reflecting new clinical evidence since the last guideline published in 2012.

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Coexistent Gout and Rheumatoid Arthritis

d Jack Cush, MD

While it is often said there is a negative association between gout and rheumatoid arthritis (RA), cases of coexistent disorders are uncommonly seen. A recent VA study describes 121 patients whith both RA and gout.

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CV Risks Raised in Myopathies

d Jack Cush, MD

Patients with the idiopathic inflammatory myopathies (IIMs) dermatomyositis and polymyositis are at increased risk for cardiovascular events, with risks similar to what has been documented for rheumatoid arthritis (RA), during the first 5 years after diagnosis, U.K. researchers reported.

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Liver Abnormalities in Psoriatic Arthritis

d Jack Cush, MD

A new report in the Journal of Rheumatology shows that liver abnormalities are common in psoriatic arthritis (PsA) and may be associated with obesity, more severe disease and select therapies.

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A msg from my nurse friend: “A blood clot from my pt yesterday. Covid lungs. I helped changed his code to DNR, talked to his son/ex wife/brother&sister to say goodbye. He asked if I would pray w/him. I prayed. He cried. Then I walked out & lost it. The public doesn’t get it.” https://t.co/AOdXshjTWL
k dao KDAO2011 ( View Tweet)
Case Controlled Study of 482 RA patients with ILD vs 741 RA w/o IL found an inverse relationship Between MTX exposu… https://t.co/ljtaKO8pVZ

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Dr. John Cush RheumNow ( View Tweet)

Rheumatologist Question: early on, what do you tell your RA patient their chance of future drug free remission?

Dr. John Cush RheumNow ( View Tweet)

Know your Risks! https://t.co/DsaEDA0VFI

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Dr. John Cush RheumNow ( View Tweet)

Pleased to share our work detailing events around HCQ and COVID-19. Started through texts with @alhkim about the news cycle being a swinging pendulum. The figure tells it all. Proud to work with @rheum_covid. We will always advocate for our patients and sound science #hcqbrigade https://t.co/O2s2Ikd6bW

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Jeff Sparks jeffsparks ( View Tweet)

Rheumatoid Arthritis: Pathogenesis, Prediction and Prevention – An Emerging Paradigm Shift https://t.co/uNDsLmgaN7 #RA #prevention #Rituximab - nice article, still think if repeated Ritux to eliminate pathogenic abs would significantly prevent RA

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Peter Nash drpnash ( View Tweet)

Study of NSAID use in 7747 patients hospitalized with influenza or influenza pneumonia found NSAID use was not associated with an increase in 30-day intensive care unit admission or death https://t.co/9LmFLeqJD2

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Dr. John Cush RheumNow ( View Tweet)

I have entered more patients with #COVID19 in the @rheum_covid registry in the last 3 days than I have in the last 3 months. Come on Texas- we can do better! Wear your mask, watch your distance, and help each other stay healthy #July4th @RheumNow

k dao KDAO2011 ( View Tweet)

Claims data study of nearly 3 million receiving influenza vaccination shows an increased risk of subsequent subdeltoid bursitis, but incredibly low with an attributable risk was 7.78 additional bursitis per 1 million vaccinated.https://t.co/qtzd8pWk4O

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Dr. John Cush RheumNow ( View Tweet)

Pneumonia vaccination of 21461 RA pts in UK Clinical Practice Research Datalink (2000-18) finds 38.2% vaccinated; 44.3% ≥65 years, 66.4% female; 36.5% vaccinated prior to starting csDMARDs, moreso in elderly. VAX increased over time (esp 2003 to 2007) https://t.co/QTedUMWvE0

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Dr. John Cush RheumNow ( View Tweet)

PRES - Posterior reversible encephalopathy syndrome. Review of US hosp records finds 3125 cases. Rheum Dz associations include ANCA+ vasculitis (OR 9.3), PsA (4.6), Scleroderma (6.6), SLE nephritis (7.5), SLE (2.4); also renal failure, pre-/eclampsia https://t.co/uLQxU3RNuD

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Dr. John Cush RheumNow ( View Tweet)

UK population study shows fibromyalgia pts have a higher risk of Self harm (HR 2.06; 1.60,2.65)), RA (HR 1.59) & OA, but not ank spondylitis. Pain and depression are risk factors for self-harm & self harm is a key risk factor for suicide.https://t.co/vXmZKYq3Pe

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Dr. John Cush RheumNow ( View Tweet)

A Genetic Probability tool used to calculate risk of rheum Dz in 3 pt cohorts (1211 eMERGE, 245 Partners & 243 early inflam arthritis. Dx AUc: 0.69, 0.81 & 0.84. Likely dx made in 64% & r/o in 45%. ?Could be used to improve Dx accuracy in clinical practice?https://t.co/JiRIxtx3j5

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Dr. John Cush RheumNow ( View Tweet)

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