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melanoma

No Certain Link between Biologics and Melanoma Risk

d Jack Cush, MD

A review of available data fails to show an increased risk of melanoma in IMID (inflammatory bowel disease, rheumatoid arthritis, and psoriasis) patients treated with systemic biologic therapies.  

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Anti-TNF and CNS Events: The Link Strengthens

d RheumNow

Patients with autoimmune diseases who were treated with tumor necrosis factor (TNF) inhibitors had an increased risk of developing inflammatory central nervous system (CNS) adverse events, a nested case-control study found.

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TNR Oz Snap

TNR - COVID-Rheumatology Registry & COVID in OZ

d

This week's Tuesday Nite Rheumatology features presentations and interviews with Drs. Peter Nash and Philip Robinson. Dr. Robinson presents latest data on the Rheum-Covid.org Registry, that he helped establish under the Global Rheumatology Alliance. Dr. Nash presents the impact of COVID in Australia and pragmatic COVID management.

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Systemic Sclerosis Future Therapies and Outcome Measures

d Jack Cush, MD

Nagaraja, Khanna and colleagues have published an overview of current and future therapies in patients with systemic sclerosis (SSc) and have reviewed the potential outcome measures for this difficult autoimmune disorder.

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A patient service Video - How to Manage your Arthritis Medications (in the time of COVID) - View the video here: https://t.co/hWW0h8wCZn or listen to the podcast on iTunes or here>> https://t.co/8wV4V2pYY5 https://t.co/SldbyCBDeI

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Dr. John Cush RheumNow ( View Tweet)
JAK inhibr safety review - Meta-analysis shows a significant 57% increase in risk of H. zoster with JAKi (RR 1.57; 1.04-2.37). Data from 82 studies, 66,159 pts w/ RA, IBD, Pso, PsA, AS. Rates of SIE=2.81/100PY and HZ=2.67/100 PY. No increase in mortality https://t.co/Tyb0VDlJOT

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Dr. John Cush RheumNow ( View Tweet)

Specialties w/ highest percentage of women? OBGYN 58%, Peds 59%, Rheumatology 54%, Derm 49%, Endocrine 45%, Family medicine 43%, Psych 43%, Pathology 40%, IM 36%, ID 36%; yet men (375K) earn 31% more than women ($286K) as specialists https://t.co/oNTwm8vRFq

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Dr. John Cush RheumNow ( View Tweet)

Metanalysis of 9 clinical trials and 1014 patients fails to show added value of subacromial decompression surgery (for subacromial pain syndrome) over sham surgery or exercise but a small risk of harm from having surgery. https://t.co/ndJpGiLV3V

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Dr. John Cush RheumNow ( View Tweet)

RA is associated with increased risk of heart failure (HF). Vanderbilt Univ EHR study compared 9889 RA pts vs 9889 matched non-autoimmune pts - RA had 21% greater risk of HF. HF assoc w/ higher CRP, Artemin and MTX assoc w/ 25% lower risk (P=0.021) https://t.co/cm5qZXZAdO

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Dr. John Cush RheumNow ( View Tweet)

Review of 525 critically ill, rheumatic dz pts (25% vasculitis, 21%SLE, 19% RA, 9% PSS, 5% myositis). ICU adm for shock (41%), respiratory failure (32%), infx (39%) Dz flares (35%). Hospital mortality was 31% predicted by age, steroids, mech ventilation. https://t.co/xcw8xU9hPl

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Dr. John Cush RheumNow ( View Tweet)

Great shout out from @philipcrobinson on @RheumNow TUES NIGHT Rheum for my ranting Tweet which launched all the hard working people who built the @rheum_covid Alliance!!! All of the RHEUMS following me regiter your pts on the site in 5 min!! Great session @CCalabreseDO #COVID19

Leonard Calabrese LCalabreseDO ( View Tweet)

Free read from Schett et al on COVID and increased proinflammatory cytokines - TNF, IL-1β, IL-6, IL-8, G-CSF ^ GM-CSF; & chemokines, such as MCP1, IP10 and MIP1α, are increased with COVID-19, with higher levels in those who are critically ill. https://t.co/My9UJ0cmPn

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Dr. John Cush RheumNow ( View Tweet)

Praise and thanks should be bestowed upon our many Medical Residents working front-line on COVID-19 in the hospital. This NPR article aptly portrays their experiences and words. Bless them for smarts and dedication! https://t.co/NxBY7kAOSG

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Dr. John Cush RheumNow ( View Tweet)

4 patients with refractory lupus panniculitis (LEP) (mean age 15 yrs) were successfully treated with rituximab, w/ a rapid and sustained RTX response https://t.co/GxmA9w89k3

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Dr. John Cush RheumNow ( View Tweet)

Rheums - Register for Tuesday Nite Rheumatology from Down Under - Dr. Peter Nash and Dr. Philip Robinson will discuss COVID-Rheum Registry and Rheumatology during COVID. Register here - https://t.co/PXJmUleQfw

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Dr. John Cush RheumNow ( View Tweet)

Effect of Covid on Practice? Medscape survey 55% drop in revenue, 60% drop Patient Volume; 43,000 healthcare workers laid off in March 2020; 9% of practices have closed temporarily; 225% increase in remote patient engagements. https://t.co/LHeYA5pE29

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Dr. John Cush RheumNow ( View Tweet)

Adaptive clinical trial design advocated for drug development for the coronavirus #COVID-19 https://t.co/jcEdlFQtXQ

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Dr. John Cush RheumNow ( View Tweet)

Grand News and much Deserved. Congrats Professor Shanmugam!! https://t.co/jUjEv9dQuM

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Dr. John Cush RheumNow ( View Tweet)

We are prioritizing the review of new ANDAs for drugs in shortage, and we recently approved a generic application for hydroxychloroquine to increase availability for patients who depend on this drug. https://t.co/eKqXlpRRQl

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Dr. Janet Woodcock DrWoodcockFDA ( View Tweet)

Please believe that the Coronavirus is not a hoax, COVID-19 is not a conspiracy. Your doubts, ideology and slick videos cant change nearly 100,000 Americans dying from COVID in 3 short months. Please be vigilant with Distance, washing and masks

Dr. John Cush RheumNow ( View Tweet)

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