All News
Preventing COVID - Masks, Meters and Eyewear
A Lancet systematic review and meta-analysis provides the basis for physical distancing and the value of making as measures to prevent infection with coronavirus 2 (SARS-CoV-2) or COVID-19.
The analysis included 172 observational studies, no randomised controlled trials and 44 relevant comparative studies involving 25 697 patients.
Hydroxychloroquine Postexposure Prophylaxis for COVID-19 Fails
NEJM has reported that the use of hydroxychloroquine did not prevent symptomatic COVID-19 infection when used within 4 days after SARS-CoV-2 exposure.
Currently for persons who are COVID exposed, the standard of care is quarantine and there is no known preventative therapy.
Read Article
TNR Grand Rounds - Update on Biosimilars
This week's Tuesday Nite Rheumatology featured Dr Jonathan Kay (U Mass) who gave an update on Biosimilars and took questions the subject. The program was moderated by Dr. Jack Cush.
Read Article
Lancet has issued an almost retraction - an "Expression of Concern" alerting readers that many have voiced scientific concerns about the Lancet HCQ/CQ paper w/ more deaths. MORE DEATHS COULD HAVE BEEN FROM THE DRUGS OR THE DRUGS BEING USED IN SICKER PTS https://t.co/saoE32qpuF
Links:
Dr. John Cush RheumNow ( View Tweet)
Open label, uncontrolled study shows that background use of azathioprine (2mg/kg) in Pegloticase treated refractory gout patients was partly effective - 6/12 completed, 2 still on Rx, 2 PEG ineffective and 2 side effx #EULAR2020 #Gout Abst#THU0410 https://t.co/APZRPCQUFg https://t.co/Nfsq4QjyA5
Links:
Dr. John Cush RheumNow ( View Tweet)
Use of HCQ was not associated with development of ❤️Heart Failure in patients with RA. There was no statistically significant association between the cumulative dose of HCQ & HF. A good study from #MayoClinic. #EULAR2020 #eular20 https://t.co/yG03e0TAcV
Mario Pompermayer, MD pompermarioMD ( View Tweet)
ILD RA has more hospital admissions. Occurs in 14% of RA. Increased mortality. Serious complication of RA @eular_org @RheumNow @CRASCRRheum @earlyarthritis #EULAR2020 OP0039 https://t.co/2N3tulzq3R
Janet Pope Janetbirdope ( View Tweet)
Nice surprise as IL23 Guselkumab works not only in PsA but axial PsA. Another Rx option also presented at @eular_org #EULAR2020 @CRASCRRheum @earlyarthritis https://t.co/dUqqagzbeC
Janet Pope Janetbirdope ( View Tweet)
Can machine learning/AI predict who will respond & get remission in RA prior to bDMARD? High dose steroids, older age high ESR long disease duration worse outcomes but not same for each drug. OP0023 @eular_org #EULAR2020 @RheumNow @CRASCRRheum @earlyarthritis https://t.co/oNXDVQbzMC
Janet Pope Janetbirdope ( View Tweet)
We're still poor at estimating the chance of remission with bDMARDs for individuals w RA - but maybe AI can help provide them with a personalised prediction of their chances of success? Remission predicted here w 57-73% accuracy.
Korean national data OP0023 #EULAR2020 @RheumNow https://t.co/zNw3j5VZni
David Liew drdavidliew ( View Tweet)
Tocilizumab in GCA - three year data from GiACTA on steroid exposure and time to flare:
- steroid-sparing benefit persists in both new-onset and relapsing disease
- in avoiding flares, benefit for weekly dosing in both new-onset and relapsing disease
OP0027 #EULAR2020 @RheumNow https://t.co/tGU6ayglHW
David Liew drdavidliew ( View Tweet)
"It's a brave new world!" Dr. Iain McInnes, president of #EULAR2020 discussing how the pandemic has created a "technological miracle" by bringing us all virtually together! @RheumNow
Dr. Rachel Tate uptoTate ( View Tweet)
Case control study to see if MTX is assoc with ILD in RA. Hypersensitivity pneumonitis pts were excluded. MTX use assoc with DELAYED onset of ILD so protective. let my RA pts use MTX if ILD or increased ILD risk ex male old +RF OP0036 @RheumNow @eular_org @CRASCRRheum #EULAR2020 https://t.co/NGM4t2OKTP
Janet Pope Janetbirdope ( View Tweet)
#EULAR2020 OP0026. RITAZAREM. Rituximab superior to Aza 2mg/kg in maintaining remission in relapsing AAV. Flare rate 13% vs 38%. Note Ritux schedule is 1g every 4 months (x 5 infusions out to month 20).
Patrick Kiely pkiely500 ( View Tweet)
Can we treat GPA /ANCA vasculitis without steroids? Apparently yes +RCT by P Merkel in #EULAR2020 plenary adding avacopan-blocks C5a. Gutsy move as No steroids in one arm! ?cost effectiveness but a breakthrough @RheumNow @eular_org @CRASCRRheum https://t.co/kp7IZOaHfP
Janet Pope Janetbirdope ( View Tweet)
Dr. R Landewe highlights #EULAR2020 #COVID19 Guidelines:
1. RMD-patients do NOT have higher risk for complications 2. Rheumatologists SHOULD BE involved in management discussions 3. Potential shortages of sDMARDS and biologics
@rheumnow https://t.co/sjQubD7mJL
k dao KDAO2011 ( View Tweet)
Patients with RA-ILD vs RA only: More likely to be older, male, white and RF positive. More likely to have COPD, Rheumatoid nodules, erosions, extraarticular disease,⬆️antiCCP,⬆️ESR & ⬆️DAS28(CRP), DAS28(ESR), CDAI & SDAI scores #EULAR2020 #eular20 https://t.co/OhI9NKpStE
Mario Pompermayer, MD pompermarioMD ( View Tweet)
SAPHO or PsA with CASPAR criteria? 1/3 of SAPHO pts meet PsA criteria (particularly active or hx of psoriasis). Interestingly, most with osteitis did not meet CASPAR criteria while those with synovitis did. #EULAR2020 @RheumNow #AB0738 https://t.co/G4p6OiocE3
Dr. Rachel Tate uptoTate ( View Tweet)
Congratulations from all of us at the BRC to Professor Paul Emery OBE for being awarded a Meritorious Award at EULAR 2020 #EULAR2020goesvirtual #EULAR2020 #FightingRMDsTogether https://t.co/z9T4AZ5P0u
NIHR Leeds BRC LeedsBRC ( View Tweet)
Guselkumab improved axial symptoms, over 24 weeks in active PsA patients with radiographic sacroiliitis. Post-hoc analysis from Discover1&2 studies (Prof P Helliwell). #OP0054. #EULAR2020, >GF
ARD & RMD Open ARD_BMJ ( View Tweet)