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COVID-19 and the Slippery Road of Cytokine Storms

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d RheumNow

Apr 21, 2020

Early reports on the COVID-19 pandemic allude to a cytokine storm or hyper-inflammation, especially in patients who succumbed to the illness.

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Lower Risk of Diabetes with Abatacept

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d RheumNow

Apr 20, 2020

Patients with rheumatoid arthritis (RA) treated with abatacept (Orencia) had a lower risk of developing diabetes mellitus compared with those receiving certain tumor necrosis factor (TNF) inhibitors, a large cohort study suggested.

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A Role for Netosis in COVID-19 Infection?

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d Jack Cush, MD

Apr 20, 2020

Journal of Experimental Medicine has published a paper from a consortium of researchers at Cold Spring Harbor Laboratory, the Feinstein Institutes for Medical Research, and the Research Institute of the McGill University Health Centre (RI-MUHC) on the potential of neutrophil extracellula

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Great lecture Alvin! Moving Forward with Telemedicine - Watch it on RheumNow or here https://t.co/pOwRCboSYe https://t.co/yU585fsDp0

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Dr. John Cush RheumNow ( View Tweet)

Apr 22, 2020

MGMA survey of practices finds that 48% of practices have experienced furloughs and 22% layoffs. There has been a 55% decrease in revenue and a 60% decrease in patient volume since the beginning of the pandemic https://t.co/20AUe9Qlro

Links:

Survey: Nearly half of medical practices have furloughed workers - MedCity News

Dr. John Cush RheumNow ( View Tweet)

Apr 21, 2020

Study from the National Inpatient Database shows that #RA pts have increased risk of hospitalizations for acute myocardial infarction. But compared to nonRA STEMI+ MI, RA- MI had a lower in-hospital mortality and cardiac arrests. https://t.co/lFHkqSgXbp

Links:

DEFINE_ME

Dr. John Cush RheumNow ( View Tweet)

Apr 21, 2020

An immunogenicity study w/ live ZOSTAVAX given ~2-wks before tofacitinib showed after mean 27 mos - 5 of 100 TOFA rx pts developed H. Zoster (at 218, 280, 748, 741, 544 days post-vaccination). OOOPs; not very protective. Use Shingrix! https://t.co/hEIJTCjJ3t

Links:

https://bit.ly/2VKLiQh

Dr. John Cush RheumNow ( View Tweet)

Apr 21, 2020

GI experts COVID guidelines, state “Despite the potential for increased exposure to SARS-CoV-2, the limited available data and expert opinion suggest that patients with IBD do not appear to have a baseline increased risk of COVID-19infection" https://t.co/kGfIMJoZGI

Links:

DEFINE_ME

Dr. John Cush RheumNow ( View Tweet)

Apr 21, 2020

Last weeks TNR Grand Rounds on "Evaluating the Febrile Rheumatic Patient" is now available as a podcast for listening on iTunes or SoundCloud Part 1 https://t.co/R5OGoB42Zi and Part 2 https://t.co/CP3HOd982A

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Dr. John Cush RheumNow ( View Tweet)

Apr 21, 2020

Riociguat a guanylate cyclase stimulator w/ antiprolif & anti-inflamm effects studied in a DBRPCT in diffuse Systemic sclerosis; There was more improvement in mRSS (-2.09 vs -0.77), Raynauds (41% vs 26%) & FVC (2.7 vs 7.6) - but these were not significant https://t.co/7aEzdDxpVY

Links:

https://bit.ly/3cyTLNj

Dr. John Cush RheumNow ( View Tweet)

Apr 20, 2020

NYU & Montreal Heart Instit. teaming on the COLCORONA study of Colchicine in early phase COVID-19 infx. TBD in 6,000 patients with mild forms of the disease. Dr. M Pillinger says colchicine, early on, may inhibit damaging inflammatory responses https://t.co/UTW2g6QU2r

Links:

https://bit.ly/2Km83ok

Dr. John Cush RheumNow ( View Tweet)

Apr 20, 2020

1st paper on the Global Rheumatology Alliance @rheum_covid registry published in Lancet Rheumatology. @ April 1st 110 COVID-19 Rheum pts enrolled from Europe, N&S America, Asia, Africa, Oceania; now up to 487 with 9894 in the patient survey. https://t.co/RI2AKsyf5T

Links:

DEFINE_ME

Dr. John Cush RheumNow ( View Tweet)

Apr 20, 2020

@LupusCanada has enhanced our survey to better understand the current situation and evolution of HcQ availability in Canada. Please share this survey with anyone impacted by this issue https://t.co/0ImHloC0JZ #LetsTalkLupus #LupusCanada #lupus

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Help Lupus Canada track the accessibility of Hydroxychloroquine

Lupus Canada LupusCanada ( View Tweet)

Apr 20, 2020

Scary as hell ! The COVID-19 death rate in the USA doubles at least every 3 days..... https://t.co/u0UTLMf3NH

Links:

Eric Topol on Twitter: "The US fatality curves, April 20th, @OurWorldInDat…

Dr. John Cush RheumNow ( View Tweet)

Apr 20, 2020

Neurologic side effects of TNFi are rare; Sweden/Denmark population study shows TNFi in AS/PsA, but not in RA, associated with increased risk of neuroinflammatory events (0.59 to 0.87 /1000PY) with TNFi and 0.19-0.40/1000PY in unexposed https://t.co/FeRtKSspXj

Links:

https://bit.ly/2yqNNiL

Dr. John Cush RheumNow ( View Tweet)

Apr 20, 2020

article in A&R details the Immunopathology, inflammatory mediators operative in cytokine storm syndrom of COVID-19 (and MAS/HLH), how to assess them and treatment options. Smart and timely article. (free read) https://t.co/3tsEVYMVRM

Links:

https://bit.ly/34Dqpe5

Dr. John Cush RheumNow ( View Tweet)

Apr 19, 2020

Check out my take on the new ACR COVID-19 Guidance for Rheumatic Disease Patients - great suggestions; but I do have a few thoughts that differ....what do you think? https://t.co/8srDPYRo0b

Links:

ACR COVID-19 Guidance for Rheumatic Disease Patients | RheumNow - Rheumatology …

Dr. John Cush RheumNow ( View Tweet)

Apr 19, 2020

The RheumNow Podcast is up! Chikungunya, OI in kids, Dementia in RA, CPPD, COVID systemic dz and ACR COVID Guidelines; watch it here>> https://t.co/Y8Thiavero or listen to the podcast on iTunes or SoundCloud here>> https://t.co/G8ixVQCWG4

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Dr. John Cush RheumNow ( View Tweet)

Apr 19, 2020

Dr M Drazner ⁦@UTSWNews⁩ Grand Rounds on #COVID19 pts w/cardiac involvement may be afebrile ⁦@RheumNow⁩ https://t.co/nKUJe1HIdl

k dao KDAO2011 ( View Tweet)

Apr 17, 2020

Great image, from a review article found here: https://t.co/dTjrqclrvy https://t.co/SwKiCfyqEX

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Dr. John Cush RheumNow ( View Tweet)

Apr 17, 2020

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