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Tuesday Nite Rheumatology Grand Rounds - Febrile Disorders

d Jack Cush, MD

Dr. Jack Cush reviews the appproach to evaluating fever in adults suspected of having a rheumatic disease, Stills disease or autoinflammatory conditions.

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RheumNow Podcast – Drive Them Crazy (4.17.20)

d Jack Cush, MD

Dr. Jack Cush reviews the news, journal articles and new ACR COVID-19 guidelines from the past week on RheumNow.com.

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Physical Therapy Superior to Steroid Injection for Knee OA

d Jack Cush, MD

Treatment options for painful knee osteoarthritis (OA) are numerous, but comparative outcomes are seldom available. A NEJM report shows that physical therapy is superior to intraarticular glucocorticoids injections assessing the outcomes 12 months after the intervention. 

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COVID-19 Systemic Involvement

d Jack Cush, MD

The presentations of the COVID-19 infection have been clearly chronicled with the worrisome onset of sore throat, dry cough, loss of smell and taste with fevers, myalgias, fatigue and the worrisome progression of pulmonary involvement in a minority.  Lab findings may include a leukocytosis,

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Rituximab in Rheumatoid Vasculitis

d Jack Cush, MD

The Journal of Rheumatology reports a retrospective, single center, analysis of 17 rheumatoid vasculitis patients who responded well to intravenous rituximab (RTX) therapy.

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ACR COVID-19 Guidance for Rheumatic Disease Patients

d Jack Cush, MD

On April 11th, the ACR Board of Directors approved a COVID-19 guidance document written by an ACR task force charged with updating and clarifying recommendations for rheumatologists and rheumatic disease patient management during the current COVID-19 crisis.

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Post 9/11 Autoimmune Disease Risk

d Jack Cush, MD

The 9/11/01 terrorist attach on the World Trade Center (WTC)  resulted in at least 2,977 fatalities, over 25,000 injuries, and caused at least $10 billion in infrastructure and property damage.  Arthritis & Rheumatology reports that dust cloud exposure among responders and

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Does Allopurinol lower mortality in gout? Metanalysis of 4 studies were split 2 yes, 2 no and overall all-cause mortality just missed significance with and adjusted HR 0.80 (95%CI (0.60, 1.05). https://t.co/sTB0Aq1lPd

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Dr. John Cush RheumNow ( View Tweet)

Wearing a face mask takes some getting used to. To get the most benefit, you need to avoid these common mistakes. https://t.co/MwLirqZdyN

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NYT Health NYTHealth ( View Tweet)

Chikungunya infection acutely shows fever, polyarthralgia, polyarthritis, HA, rash & GI Sxs; up to 60% develop chronic polyarthritis that mimics #RA. A retrospective report of 48 pts Rx w/ MTX (mean 9.2/wk) shows signif better pain and swollen joints. https://t.co/XEbvjSQOlx

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Dr. John Cush RheumNow ( View Tweet)

Sweets syndrome in NEJM: 54 yoM with UC has 3d of fever and abdominal pain after surgery, developed painful pustules and vessicles on neck and trunk w/ WBC 18k, ESR 40 and Bx w/ neutrophils and edema in the upper dermis. https://t.co/g1SDNS0CMS

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Dr. John Cush RheumNow ( View Tweet)

Henderson et al article in A&R details the Immunopathology, inflammatory mediators operative in cytokine storm syndrom of COVID-19 (and MAS/HLH), how to assess them and treatment options. Smart and timely article. (free read) https://t.co/3tsEVYMVRM

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Dr. John Cush RheumNow ( View Tweet)

Xray Chondrocalcinosis does not predict the need for future TKR. Study of 656 knee OA patients found 93 (14.2%) with knee Chondrocalcinosis, and 91 (13.9%) who went onto TKR. TKR odds - not affected by the presence of knee CC (HR 1.26; 0.74–2.17) https://t.co/3JKzFjSvK1

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Dr. John Cush RheumNow ( View Tweet)

FDA Grants Fast Track Designation to Telitacicept as a Treatment for #SLE. Telitacicept is a recombinant fusion protein of TACI receptor & the Fc domain of IgG1, inhibiting B cell activity by neutralizing BLyS and APRIL. + results at #ACR2019 https://t.co/7ndMWb2Rjf

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Dr. John Cush RheumNow ( View Tweet)

Check out my take on the new ACR COVID-19 Guidance for Rheumatic Disease Patients - great suggestions; but I do have a few thoughts that differ....what do you think? https://t.co/8srDPYRo0b

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Dr. John Cush RheumNow ( View Tweet)

"Real strength has to do with helping others." - Mr Rogers

Dr. John Cush RheumNow ( View Tweet)

Congratulations to the ACR's North American Task Force in rising to the occasion so quickly to put forth the ACR COVID-19 Clinical Guidance for Patients with Rheumatic Diseases https://t.co/IFu8tvMpCh

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Dr. John Cush RheumNow ( View Tweet)

PharmaChild registry & PRINTO analyzed the risk of opportunistic infx (OI) among 8274 JIA - identified 772 adjudicated inFx, 119 (17%) were OI - most common were herpes zoster (66), TB (11), candida (3), HPV (4), PJP (4), CMV (3). https://t.co/UohADllivV

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Dr. John Cush RheumNow ( View Tweet)

“Listening is where love begins: listening to ourselves and then to our neighbors.” - Mr. Rogers

Dr. John Cush RheumNow ( View Tweet)

In Italy, mention of #RA as one of the casues of death was increasingly noted from 2003 to 2015 but decreased as the main or underlying cause of death https://t.co/fPzs5k7XOa

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Dr. John Cush RheumNow ( View Tweet)

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