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Malignancies with Giant Cell Arteritis

d Jack Cush, MD

The Journal of Rheumatology reports the findings of a Swedish population-based cohort study of biopsy-proven giant cell arteritis (GCA) patients showing that the overall risk for cancer was not increased; yet there appears to be an increased risk for leukemia and a decreased risk for breast and u

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EMA Final Recommendations on VTE Risk with Tofacitinib

d Jack Cush, MD

On 14 November 2019 the European Medicines Agency (EMA) concluded that Xeljanz (tofacitinib) could increase the risk of blood clots in the lungs and in deep veins in patients who are already at high risk.  These recommendations have been formally published and are intended for EU nation

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Hospitalized GPA - Higher morbidity, Mortality and Cost

d Jack Cush, MD

Rheumatology reports on a study of patients with granulomatosis with polyangiitis (GPA) showing worse outcomes and higher costs when hospitalized with GPA.

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Diabetes in OA: Pain Is Worse

d RheumNow

Among patients with knee osteoarthritis (OA), pain was greater for those with coexisting diabetes mellitus (DM), and this association was independent of obesity and radiographic severity, European researchers found. 

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Annals of Internal Medicine has a Full read REVIEW of FIBROMYALGIA https://t.co/4Ux6rqIkHo

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Dr. John Cush RheumNow ( View Tweet)

Study of 179 RA pts, 21% with ILD, shows Anti-CarP Abs were strongly associated with ILD ( OR 3:4). The role of homocitrullination in RA-ILD merits further investigation. https://t.co/F621UJ8REx

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Dr. John Cush RheumNow ( View Tweet)

"Play the game for more than you can afford to lose... only then will you learn the game." - Winston Churchill

Dr. John Cush RheumNow ( View Tweet)

Rheumatic dz pts from British Columbia; compared 185 DMARD exposed Pregnancies vs 6,064 PREG NOT exposed. HCQ, AZA, SSZ before/during PREG not assoc w/ SGA births. 1st trimester MTX incr odds for congenital anomalies (aOR 6.58; 1.15-37.75). https://t.co/Kz5819lk1q

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Dr. John Cush RheumNow ( View Tweet)

UK population study shows that being over age 65 yrs increased the odds of receiving Seasonal influenza vaccination; but was without a reduction in hospitalizations or mortality among elderly persons. Call for new strategies https://t.co/viXwS5yx7W

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Dr. John Cush RheumNow ( View Tweet)

2016 Americans spent $3.1 trillion($9,655/person) on healthcare - 17.9% of the US GDP. Included $380 billion on low back and neck pain (the highest) and $80.0 billion on osteoarthritis. https://t.co/OniyxzDnRu

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Dr. John Cush RheumNow ( View Tweet)

EHR analysis of two health systems on finds among 3,577 # RA pts; 507 smoked and 29% quit over 4.7 yrs. More likely to quit were new Care pts (aOR 1.60), and rural community health system pts (1.66); Seropositives were less likely to quit (0.57) https://t.co/gWcWoZpRVo

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Dr. John Cush RheumNow ( View Tweet)

1 year results of the ustekinumab in SLE trial encouraging. 1st 6 mos DBRPCT showed UST 62% vs PBO 33%. At wk 48 UST SRI4 responses maintained 63.3%; PBO crossovers caught up. 15% had seriour adverse events. https://t.co/XauG4JOJIj

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Dr. John Cush RheumNow ( View Tweet)

Korean National Health claims study shows there was a significant increased risk of incident #RA 6-7 weeks following respiratory viral infections (parainfluenza, coronavirus, metapneumovirus), most evident in women and elderly. https://t.co/njXTGzdj7r

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Dr. John Cush RheumNow ( View Tweet)

NEJM clinical case - 42-year-old man with cough and shortness of breath. Ex showed a saddle-nose deformity, CT showed destruction of the nasal bones with the formation of a large nasal cavity. Your Dx? https://t.co/DgLfFigntK

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Dr. John Cush RheumNow ( View Tweet)

"An appeaser is one who feeds a crocodile, hoping it will eat him last." - Winston Churchill

Dr. John Cush RheumNow ( View Tweet)

FDA Requires Stronger Warning About Risk of Neuropsychiatric Events Associated with Asthma/Allergy Medication Singulair and Generic Montelukast. FDA review finds reports of \agitation, depression, sleeping problems, suicidal thoughts and actions. https://t.co/eJPVB3lS3s

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Dr. John Cush RheumNow ( View Tweet)

QD Clinic Compilation podcast from last week - hear about: Undertreatment, Involving the Dermatologist, the 7th DMARD, Hypermobility syndrome & Pred in Hand OA. Listen to the compilation (81-85) on iTunes or SoundCloud https://t.co/GNwt9ohHRe

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Dr. John Cush RheumNow ( View Tweet)

QD Clinic 85 - HOPE for Hand OA; Watch it here https://t.co/GNwt9ohHRe or listen to it on the podcaast https://t.co/xCwyYqx0sM

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Dr. John Cush RheumNow ( View Tweet)

News » RheumNow Podcast is up (3.6.20)! Reports on GCA, ANA in Liver Dz, Sleep apnea in RA, COPD causing RA, Aldolase in Still's, Venon as a vector. Watch it here>> https://t.co/znNXBkziBD or listen to the podcast on iTunes or SoundCloud >> https://t.co/fVPAoXYPgW

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Dr. John Cush RheumNow ( View Tweet)

Tocilizumab (Actemra) has been approved by the Chinese government to treat severe #coronavirus symptoms 👉🏽https://t.co/ETEQTga6GB #COVID2019 #COVID #CoronavirusOutbreak #Coronavid19 #covid19 #Covid_19 #CoronaAlert https://t.co/EoVGaYtkX4

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Dr Ai Lyn Tan DrAiLynTan ( View Tweet)

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