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Severity Associated with Erosive Hand Osteoarthritis

May 18, 2021 5:54 pm

Erosive hand osteoarthritis (EHOA) was studied as part of the Osteoarthritis Initiative, and shown to increase with advanced age and female sex, with developmental findings to suggest that EHOA as a disorder of skeletal frailty.

The Osteoarthritis Initiative is a longitudinal study of OA patients followed clinical and with radiographs from baseline and 48‐months. EHOA was defined as Kellgren‐Lawrence (KL) grade≥2 changes in in at least one interphalangeal joint on two different fingers and central erosion in at least one joint.

From a total of 3365 patients without EHOA at baseline, 2.6% (86) developed EHOA over 48‐months of observation.

Risk factors included being older [RR 0.76), female [RR=1.73, greater osteoarthritis severity and less cortical width (AKA "thinner bones";  1.38 vs 1.52 mm, p<0.001).

Those developing EHOA had greater progressions of radiographic osteoarthritis and loss of cortical thickness. 

These findings suggest that EHOA is a consequence of more severe OA and may be a disorder of skeletal frailty.

The author has no conflicts of interest to disclose related to this subject

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