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Airway Inflammation Drives Rheumatoid Risk

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d Jack Cush, MD

Mar 04, 2020

A cohort analysis of the Nurses' Health Study suggests that asthma and COPD are associated with increased risk for incident rheumatoid arthritis (RA), independent of smoking- thus airway inflammation may be an important factor in the evolution of pre-cllnical RA.

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Don't Blame the Weather in Sjogren's

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d RheumNow

Mar 03, 2020

Seasonal variations in symptoms -- commonly reported by patients with rheumatic diseases -- were not observed in a large cohort of patients with primary Sjogren's syndrome, French investigators found.

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Folate Levels Protect from CV Mortality in RA

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d Jack Cush, MD

Mar 02, 2020

In a study of rheumatoid arthritis (RA) patients, JAMA reports that serum folate level of greater than 4.3 ng/mL was associated with lower CV mortality risk.

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Interleukin-37 Targeting in Gout

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d Jack Cush, MD

Mar 02, 2020

The Annals of Rheumatic Disease reports that interleukin- 27 (IL-37) may play an important role in the pathogenesis of gout, paving the way for future therapy with recombinant IL-37 in gouty arthritis.

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RheumNow Podcast- Methotrexate Mechanisms (2.28.20)

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d Jack Cush, MD

Feb 28, 2020

Dr Jack Cush Reviews the news and journal articles from the past week on RheumNow.com

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Cohort study shows that RA pts who develop ESRD incur cardiac events sooner than the general population. However, RA is not an independent risk factor for all-cause or cardiovascular mortality in ESRD. https://t.co/9Vj6UPkAHM

Links:

Rheumatoid Arthritis and Mortality in End Stage Renal Diseas... : JCR: Journal…

Dr. John Cush RheumNow ( View Tweet)

Mar 04, 2020

Study of 199 pts shows ncreased prevalence of obstructive sleep apnea (OSA) in rheumatoid arthritis pts (based on polysomnography) with moderate-to-severe OSA (AHI ≥ 15) in 23% https://t.co/tGGa8dGyrG

Links:

http://bit.ly/3alP6gq

Dr. John Cush RheumNow ( View Tweet)

Mar 04, 2020

45 SLE transverse myelitis pts compated to SLE neuromyelitis optica pts (NMO). SLE-TM frequently had fever, anticardiolipin Abs and lupus anticoagulant. NMO had lower incidence of rash, serositis, renal Dz less abnormal serologies (dsDNA, C3, Sm) https://t.co/JHN3b6qoKz

Links:

SAGE Journals: Your gateway to world-class journal research

Dr. John Cush RheumNow ( View Tweet)

Mar 04, 2020

Johnston County OA Project (1999–2015) found 327/800 with Xray hand OA (rHOA) - they were older, more often white and female. Women were more likely than men to have incident HOA, particularly for DIP rOA. HOA more frequent in whites vs AA https://t.co/wdXlrNqsIG

Links:

DEFINE_ME

Dr. John Cush RheumNow ( View Tweet)

Mar 03, 2020

Serum aldolase serves as a useful marker for diagnosis and assessment of disease activity in patients with adult-onset Still's disease. https://t.co/K1Z8uqLwML

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Serum aldolase serves as a useful marker for diagnosis and assessment of diseas…

Dr. John Cush RheumNow ( View Tweet)

Mar 03, 2020

"There are a terrible lot of lies going about the world, and the worst of it is that half of them are true." - Winston Churchill

Dr. John Cush RheumNow ( View Tweet)

Mar 03, 2020

CDC reports 16,000 deaths & 280,000 hospitalization from the2019-20 influenza. US Corona -just 2 deaths and 22 infected; means you should be 8000-100,000 times more worried about the FLU - NOT CORONA. Remember EBOLA, SARS, ZIKA - alot of press but no US IMPACT. Turn off your TV.

Dr. John Cush RheumNow ( View Tweet)

Mar 02, 2020

Todays QD Video https://t.co/k5D2xmRhRX is also a podcast https://t.co/HzlY18qoEN about what to do when noncompliance gives you a brain fog.

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Dr. John Cush RheumNow ( View Tweet)

Mar 02, 2020

RAPPORT registry studied 162 pts w/ RA & PsA w/ 234 pregnancies. 1/3 had fewer children than desired. 63 preg after Dx - 2/3 had good control during pregnancy but 3/4 flared w/in 3 mos postpartum; & 35% of pregnancies conceived on biologics https://t.co/Vg8OaRLfyt

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Peripartum issues in the inflammatory arthritis patient: A survey of the RAPPOR…

Dr. John Cush RheumNow ( View Tweet)

Mar 02, 2020

Vitamin D deficiency is associated with lumbar disc disease and LBP in postmenopausal women; moresoe w/ very low vitamin D concentration < 10 ng/mL - study of 232 postmenopausal women https://t.co/Kmu8nMOaf7

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Does vitamin D status influence lumbar disc degeneration and... : Menopause

Dr. John Cush RheumNow ( View Tweet)

Mar 02, 2020

U.S. FDA Accepts Regulatory Submission for Tanezumab, an NGF inhibitor, for the Treatment for Patients with Chronic Pain Due to Moderate-to-Severe Osteoarthritis https://t.co/9NsESTnn4S

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U.S. FDA Accepts Regulatory Submission for Tanezumab, a Potential First-in-Clas…

Dr. John Cush RheumNow ( View Tweet)

Mar 02, 2020

"He has all of the virtues I dislike and none of the vices I admire." -Winston Churchill

Dr. John Cush RheumNow ( View Tweet)

Mar 02, 2020

QD Clinic - Cases, insights and RNL info. Listen to the podcasts on iTunes or here https://t.co/V60JN2ZdYF

Links:

http://bit.ly/2wmvMRu

Dr. John Cush RheumNow ( View Tweet)

Mar 01, 2020

The RHeumNow Podcast is up. https://t.co/pD2fWDsCOJ Checkout the podcast >> https://t.co/x0RytGbNYi

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Dr. John Cush RheumNow ( View Tweet)

Mar 01, 2020

Long term safety of Sarilumab reviewed. 2887 SAR pts on Combo and 471 on SAR mono Rx for up to 7.3 yrs (8188 PYs). SAEs 9.4 & 6.7/100PY; SIE 3.7 &, H zoster (0.5-0.6/100PY), GI perforations < 0.1/100PY & Cancer 0.7-.6. ANC <1000 in 13-15% https://t.co/YA2TKCdpGY

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Long-term safety of sarilumab in rheumatoid arthritis: an integrated analysis w…

Dr. John Cush RheumNow ( View Tweet)

Feb 28, 2020

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