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Here’s what I think is missing in RA for JAKi trials. Mono therapy post MTX-IR vs TNFi. Comparisons head2head with other biological and post JAKi RCT of another JAKi. @RWCSmtg @RheumNow #RWCS2020 #JAK
Janet Pope Janetbirdope ( View Tweet)
Fenebrutinib, a BTK inhibitor, is better that placebo, but not ADA when given in a phase 2 trial. Drs. Fleischman/Genovese at #RWCS2020 @RWCSmtg https://t.co/lOtFoB80s3
Dr. John Cush RheumNow ( View Tweet)
Do we need another IL6 inhibitor for rheumatic diseases. Tocilizumab is off patent in USA and Europe. We have Sarilumab but Sirukumab did not go forward in RA. Another kid on block - Olokizumab IL6 receptor blocker with +RA RCT #RWCS2020 @RWCSmtg @RheumNow https://t.co/OwhnRjwPrt
Janet Pope Janetbirdope ( View Tweet)
Sky kinases are terminally sick. DNR for RA trials. Another one bites the dust. @RWCSmtg @RheumNow #RWCS2020 https://t.co/GbnEfkOR7p
Janet Pope Janetbirdope ( View Tweet)
Learning from rheum colleagues @RWCSmtg upadacitinib rate of vte similar to adalimumab and mtx. Suggests it’s the disease rather than the drug. https://t.co/KG8CionFbN
Uma Mahadevan UmaMahadevanIBD ( View Tweet)
“Autoimmunity can be the initial presentation of immunodeficiency.” Dr. A. Postolova #RWCS2020 @RheumNow @RWCSmtg
Dr. Rachel Tate uptoTate ( View Tweet)
25% of PID pts will develop an autoimmune disease. Here are Dr. Postolova’s 10 warning signs. Left for children and right for adults. #RWCS2020 @RheumNow @RWCSmtg https://t.co/mxQ2urQQ9G
Dr. Rachel Tate uptoTate ( View Tweet)
Primary immunodeficiency warning signs in adults; 25% of OID will develop an autoimmune disease. Dr Anna Postolova at #RWCS2020 @RWCSmtg https://t.co/c84Sybg95W
Dr. John Cush RheumNow ( View Tweet)
Fenebrutinib, a BTK inhibitor, is better that placebo, but not ADA when given in a phase 2 trial. Drs. Fleischman/Genovese at #RWCS2020 @RWCSmtg https://t.co/lOtFoB80s3
Dr. John Cush RheumNow ( View Tweet)
A favorable safety profile for Filgotinib, maybe less zoster and VTE. Drs. Fleischman/Genovese at #RWCS2020 @RWCSmtg https://t.co/yNn8tl3R8c
Dr. John Cush RheumNow ( View Tweet)
Finch 3 trial in MTX naive pts shows that mono Rx FIL 200=MTX mono for ACR20 but FIL200 superior for ACR50/70. 200mg works faster with more big responders early. Drs. Fleischman/Genovese at #RWCS2020 @RWCSmtg https://t.co/msgB6DS5cl
Dr. John Cush RheumNow ( View Tweet)
Finch 1 trial of Filgotinib vs adalimulmab in MTX IR #RA pts shows FIL 200 is superior to FIL 100 or ADA 40. Drs. Fleischman/Genovese at #RWCS2020 @RWCSmtg https://t.co/rMLtnLK73B
Dr. John Cush RheumNow ( View Tweet)
Last day for #RWCS2020 in #Maui - Dr. Roy Fleischmann @UTSWNews and Dr. Mark Genovese @StanfordHealth talk updates on promising new molecules such as #upadacitinib https://t.co/VWYYO6gMpR https://t.co/drfWXpiPCs
Healio Rheumatology HealioRheum ( View Tweet)
SELECT-COMPRE study shows that if you don't respond to either ADA or UPAD you can successfully switch to the other. Drs. Fleischman/Genovese at #RWCS2020 @RWCSmtg https://t.co/wKx1ceu50X
Dr. John Cush RheumNow ( View Tweet)
Talk on SAPHO includes dance from singer SAPHO. Way to go Anne Stevens #RWCS2020 @RheumNow PS SAPHO is synovitis acne pustulosis hyperostosis osteitis #RWCS2020 @RheumNow https://t.co/S3wVEtZ3OJ
Janet Pope Janetbirdope ( View Tweet)
A novel TYK2 inhibitor may provide clinicians with another treatment option along the janus kinase pathway in patients with severe #psoriasis, said Dr. George Martin at #RWCS2020 @RWCSmtg https://t.co/i630rfoxnl
Healio Rheumatology HealioRheum ( View Tweet)
Do you use MTX in your PsA patients with PsO? @RheumNow @RWCSmtg #RWCS2020
Dr. Rachel Tate uptoTate ( View Tweet)
#RWCS2020 Day 3 kicks off with Dr. Eric Ruderman @NUFeinbergMed and Dr. Arthur Kavanaugh @UCSDHealth addressing #psoriaticarthritis developments, including #microbiome and #epigenomic connections to #psoriasis
https://t.co/VWYYO6gMpR https://t.co/HkH31vUICG
Healio Rheumatology HealioRheum ( View Tweet)
Is #telemedicine the future for #rheumatology or a potential legal nightmare? Dr. Alvin Wells @DukeHealth and Dr. Orrin Troum @KeckMedUSC square off on this new avenue for #patient care at #RWCS2020 https://t.co/VWYYO6gMpR https://t.co/Jb9uK5xPeg
Healio Rheumatology HealioRheum ( View Tweet)
What is your “go to” treatment for skin dz in early dcSSc? Dr. Pope @RheumNow @RWCSmtg #RWCS2020
Dr. Rachel Tate uptoTate ( View Tweet)