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RheumNow Podcast – I Wanna New Drug.V2 (9.24.2021)

Jack Cush, MD
Sep 23, 2021

Almost three years ago to the day, I did a podcast entitled, "I wanna new drug." As I go over this week's podcast, I want to say it again. I want a new drug safe enough to use during pregnancy, for PMR, for GVHD, and more. I'm going to cover these, and other topics including lupus, COVID breakthrough infections, and statin use and the risk of RA, as I review the news and journal articles from the past week on RheumNow.

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Retrosp. review of 10–24 yr olds w/ newly Dx #SLE shows 78% given steroid-sparing DMARDs by year 1; Most (69%) given HCQ & fewer (34%) given other immunosuppressants. Adults less likely to recv immDMARDs @1 yr https://t.co/aLi6FXlMd3

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Dr. John Cush RheumNow ( View Tweet)

Sep 22, 2021
arm,muscle,weak

High Comorbidity Rates with Inclusion Body Myositis

Jack Cush, MD
Sep 21, 2021

Inclusion body myositis (IBM) patients tend to be older than those with idiopathic inflammatory myositis (IIM), but the scope of disease beyond their myositis is not appreciated.

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Lupus Research Alliance has awarded $3 million Global Team Science Awards to Drs Virginia Pascual (Weill Cornell Med Schoo) and Ignacio Sanz (Emory Univ Medial School) for their proposed collaborative, translational lupus projects. https://t.co/ecMlHiZfwe

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Dr. John Cush RheumNow ( View Tweet)

Sep 21, 2021
Breakthrough infections from UK QResarch database: Among 6.95 million vaccinated, 74.1% recv two vaccine doses, there were 2031 covid-19 deaths & 1929 hosp admissions; ~4.0% deaths & admissions were >14 days after 2nd dose https://t.co/bbDsb1zLhX

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Dr. John Cush RheumNow ( View Tweet)

Sep 20, 2021
Patients with systemic lupus erythematosus (SLE) had two to four times higher risk for serious infection requiring hospitalization, a nationwide Swedish study found. https://t.co/ilkqTtZjVL #RheumNow https://t.co/hzcqlNUF66

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Dr. John Cush RheumNow ( View Tweet)
Sep 20, 2021
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Serious Infection Risk High in Patients With Lupus

MedPage Today
Sep 17, 2021

Patients with systemic lupus erythematosus (SLE) had two to four times higher risk for serious infection requiring hospitalization, a nationwide Swedish study found.

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RheumNow Podcast – High Science and Future Treatments (9.10.2021)

Jack Cush, MD
Sep 10, 2021

This week: high science that affect future treatments; breakthrough infections in our patients, and what's up with that; and soon your radiologist is going to be replaced by AI. This and more in our review of the news and journal articles from the past week.

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Risk Factors Associated with Systemic Sclerosis Hospitalization

Jack Cush, MD
Sep 09, 2021

A retrospective study of systemic sclerosis patients shows that acute hospitalization and mortality were not uncommon and were often linked to SSc-related lung disease.

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Analysis of records from the Mass General Brigham healthcare system in the Boston area, shows that breakthrough infections (after receiving SARS-CoV-2 vaccines) in patients with SARDs are not uncommon, and may be severe or fatal. https://t.co/Ri5QipR7YY https://t.co/TaTFTKfAzm

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Dr. John Cush RheumNow ( View Tweet)
Sep 09, 2021
Covid lung pneumonia corona (keep)

COVID Breakthrough Infections in Rheumatic Patients

Jack Cush, MD
Sep 08, 2021

Analysis of records from the Mass General Brigham healthcare system in the Boston area, shows that breakthrough infections (after receiving SARS-CoV-2 vaccines) in patients with systemic autoimmune rheumatic diseases (SARDs) are not uncommon, and may be severe or fatal.

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Two cohorts from the Nurses’ Health Study (1984–2014 & 1991–2013) showed no association between diet & increased risk of incident #SLE; but that a high nut/legume diet may be associated with a reduced SLE risk https://t.co/mbBs7KZA6A

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Dr. John Cush RheumNow ( View Tweet)

Sep 08, 2021
ICYMI: Using inpatient hospital records of 1.9 million SLE pts, the mortality of hospitalized #SLE changed little from 2006-2016;mortality dropped from 2.2% to 1.5% - with most of this decline between 2006-‘08 and no change since. Racial disparities seen. https://t.co/UUsJYFxQS4

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Dr. John Cush RheumNow ( View Tweet)

Sep 05, 2021
Using inpatient hospital records of 1.9 million SLE pts, the mortality of hospitalized #SLE changed little from 2006-2016; mortality dropped from 2.2% to 1.5% - with most of this decline between 2006-2008 and no change since. Racial disparities seen. https://t.co/UUsJYFxQS4

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Dr. John Cush RheumNow ( View Tweet)

Sep 02, 2021
Multi-center study of 215 pediatric SLE patients - 55%(118) w/ Hematologic findings: most common anemia (88), hemolytic anemia (4). Signif assoc w/ HEME dz: Renal Dz, low C3, APL Abs, anti-β2 GP1, Sm, LAC, high SLEDAI. Most Rx w/ steroids, IVIG or RTX https://t.co/nuD524kkD4 https://t.co/6a14bQ6SQ6

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Dr. John Cush RheumNow ( View Tweet)
Sep 01, 2021
Watch: Drs. Jack Cush, Kathryn Dao ( @KDAO2011) , Janet Pope ( @Janetbirdope) Eric Dein ( @ericdeinmd) and Yuz Yusof discuss a number of lupus presentations presented at the virtual EULAR 2021 meeting. #RheumNow https://t.co/yUEXTOatpR

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Dr. John Cush RheumNow ( View Tweet)

Aug 31, 2021
NIAID will study COVID‐19 Booster Vaccine in Autoimmune Disease Non‐Responders (including MS, RA, SLE, Scleroderma,pemphigus); 20 sites, 600 pts (taking MTX, MMF or RTX) w/ poor resp to mRNA vax & recv 3rd booster vax. https://t.co/YwCvGnX21F https://t.co/th2WoRv1ng

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Dr. John Cush RheumNow ( View Tweet)

Aug 31, 2021
NIAID will study COVID‐19 Booster Vaccine in Autoimmune Disease Non‐Responders (including MS, RA, SLE, Scleroderma,pemphigus); 20 sites, 600 pts (taking MTX, MMF or RTX) w/ poor resp to mRNA vax & recv 3rd booster vax. https://t.co/YwCvGnX21F https://t.co/th2WoRv1ng

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Dr. John Cush RheumNow ( View Tweet)

Aug 31, 2021
Swedish study of 287 SLE pts shows rare risk of autoimmune liver disease. While 14% had persistent LFTs, only 2.8% dx w/ autoimmune hepatitis. 1.4-2.1% met criteria for primary biliary cholangitis. Both AIH & PBC AIH are overrepresented in SLE https://t.co/oc5SLJtycf

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Dr. John Cush RheumNow ( View Tweet)

Aug 27, 2021
Brazilian national study of 319 SLE & 251,800 nonSLE pts hospitalized with COVID-19 showed that SLE increases risk of death (RR 1.74) & poor outcomeS (RR 1.39). Having lupus doubled (RR 2.2) the risk of risk of death. https://t.co/8VJjdOEuzS

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Dr. John Cush RheumNow ( View Tweet)

Aug 27, 2021

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