Twofold Mortality in SLE Save
Despite declining incidence of lupus, mortality for SLE was twice that of controls in this large incident cohort study.
Ethnicity is a strong predictor of incidence and outcomes in systemic lupus erythematosus (SLE) patients. This population study used the UK Clinical Practice Research Datalink that included 4937 adults with new SLE diagnoses between 2012 and 2023 were included. Controls (N = 19 707) were matched to patients in a 4:1 ratio.
Over the study period, the incidence of SLE declined over the study period across all ethnicities.
SLE patients had significantly higher mortality risk (HR 2.06, 95% CI 1.84–2.32) and elevated risk of all studied complications except solid cancers.
SLE incidence was highest among Blacks. especially in Black Caribbean individuals (11.07 per 100 000 person-years.
Compared to whites, black individuals had significantly higher mortality (HR 1.64, 95% CI 1.05–2.55) and increased risks of diabetes, thrombosis, myocarditis/pericarditis, and interstitial lung disease.
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