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Stop Counting Bugs (10.4.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.This week’s rants include the microbiome, PsA treatment choices and fishing for P-values in research.

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JAMA metaanalysis of psoriasis pts (40 RCTs, 21 438 pts) Rx w/ biologics: a >=90% PASI (skin) response was less likely with older age, prior biologics, higher BMI, and smoking https://t.co/v5EpOpYVYt https://t.co/wXTXP76Emu

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JAMA Patient Education Page - Plantar Fasciitis Plantar Fasciitis accounts for more than 1 million US clinic visits per year. People at risk include obesity, jobs w/ prolonged standing https://t.co/uijbcbQ0sz https://t.co/VISMU3UxKF

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Which One is the Loneliest Number (9.27.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the regulatory approvals, announcements, guidelines and interesting journal articles from the past week on RheumNow.com. When not to use muscle relaxants, how frequent is loneliness in RA/PsA/SpA, and when to refer patients with Still's disease.

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2612 BSRBR-RA Registry pts on tocilizumab - increasing Body weight was associated with reduced DAS28 response to SC tocilizumab. But the DAS28 difference was small, and did not change drug persistence https://t.co/eR7kmjRaEE https://t.co/vFKYC1I3pV

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Linger on the Fingers (9.6.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. This week with a focus on fingers and better prescriptive follow through.

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Prospective Nurses' Health Study (n 204,175) included 212 w/ incident SLE; ultraprocessed food intake was assoc w/ >50% increased SLE risk & doubled risk for anti-dsDNA Abs. Sugar-/artificially sweetened drinks assoc w/ lupus risk (HR 1.45) https://t.co/jesfsgNvUY https://t.co/KQupBkEcKg

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Gluten can be "a wicked antigen". Full read Review of the potential role of gluten in inflammation and autoimmunity. Undigested gluten peptides can be modified by luminal transglutaminase or delivered to gut mucosal immune cells https://t.co/eonHfpZZiN https://t.co/iKwbzg2Lbu

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Higher Cancer Rates (8.16.2024) Dr. Jack Cush reviews the news and journal reports from the past week on https://t.co/V10S4oVFsv, noting his concerns about diet, cancer, ILD, death and dosing challenges. https://t.co/thNOPkYWRM https://t.co/ZFwvE80e7Q

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Higher Cancer Rates (8.16.2024) Dr. Jack Cush reviews the news and journal reports from the past week on https://t.co/V10S4oVFsv, noting his concerns about diet, cancer, ILD, death and dosing challenges. https://t.co/thNOPkYWRM https://t.co/ZFwvE80e7Q

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From 25K prediabetics, 1,521 had serial serum Uric acid measures. Predictors of increaed SU levels included Older age, male sex, greater BMI, and higher HbA1c. Those w/ a BMI ≥30 kg/m2 exhibited higher SU levels https://t.co/ztp8M781Dw https://t.co/PNaZxMIOlG

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Anti-Inflammatory Diet yields a lower risk of Dementia. UK Biobank study shows patients w/ type 2 diabetes, heart disease, or stroke who were on an anti-inflammatory diet had a 31% lower risk for dementia vs. a pro-inflammatory diet https://t.co/OjHq3BBOfd https://t.co/tG9vO59IEc

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Higher Cancer Rates (8.16.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com, noting his concerns about diet, cancer, ILD, death and dosing challenges.

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CV,risk,MI,heart,cardiac

Less Mortality with GLP-1 Agonists in Rheumatic Patients

d Jack Cush, MD

A recent article in PLOS ONE has shown that treatment of type 2 diabetes with glucagon-like peptide-1 receptor agonists (GLP-1-RAs) was associated with a significant lowering of risk of all-cause mortality and major adverse cardiovascular events in patients with immune-mediated inflammatory diseases and type 2 diabetes.

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355 PsA (n=279) & psoriasis (76) pts studied. PsA pts had more comorbidity vs PsO (43% v 26%). >70% low exercise level. Exercise signif improved DAPSA, TJC/SJC, ESR, PASI. Hi Mediterranean diet decr ESR, PASI, but signif only for enthesitis (p 0.015) https://t.co/mdruLj9h5a https://t.co/NOiwXju0wm

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EMR study looked at NIDDM & 4 indicators of #Obesity (waist circumference, waist/hip ratio, BMI, & visceral fat area -- 600 gout pts vs 9,935 controls shows all obesity measures signif incr odds of #Gout (OR 1.775, 1.691, 1.858, & 1.578, respectively) https://t.co/JJn5txgxiN https://t.co/tgnWWl9COe

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Medical literature review of suggests low vitamin D status is common in Rheumatic pts. & low vit D levels linked to loss of muscle strength, MSK pain, sarcopenia & falls (esp in IIM, PMR, SLE, RA, SSc) (BUT DOES REPLACING VITAMIN D FIX THESE PROBLEMS???) https://t.co/30IiKj7l4d https://t.co/ydU6FQMTi5

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Lead with Lupus (8.2.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com - leading with lupus because everyone wants to know about lupus!

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Location, Location, Location (7.26.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Location matters; Geo-rheumatology?

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DBRPCT of Krill oil (4 g/d;KOC) vs PBO in 78 #SLE pts for 24 wks. KOC Rx pts had signif increase in Omega-3 Index 4.3% to 7.17% (4wks) to 8.05% (24wks) w/ no change SLEDAI-2K. But 9pts w/ hi activity (SLEDAI≥9) showed signif Dz activity improvements https://t.co/ODLqqZzGQx https://t.co/tehHk4MhbZ

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