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Genetic Analysis of Asymptomatic Antinuclear Antibody Positive Patients
A large scale genomic population study found antinuclear antibodies (ANA) in up to 14% of the population; most with ANA are asymptomatic, and ANA production is not associated with significant genetic risk.
Genomics and Future Drug Targets for Osteoarthritis
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EurekAlert!
A Nature article details the results of an osteoarthritis, genome-wide association study meta-analyses across up to 489,975 cases and 1,472,094 controls, establishing 962 independent associations, 513 of which have not been previously reported.
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Distinguishing Septic and Gouty Arthritis
A single center, retrospective review of patients undergoing knee joint fluid aspirations for presumed crystalline arthritis (CA) showed that synovial WBC may provide a useful diagnostic marker for SA with an optimal threshold of 50,000 cells/mm3.
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Predictors of Developing RA
A prospective cohort study of seropositive arthralgia patients demonstrated that baseline characteristics and labs can be used to predict which arthralgia patients are at highest risk of developing rheumatoid arthritis (RA).
AutoAbs & protein signatures evolve as pts go from Preclinical to established RA. Pts vs controls distinguished w/in 5 yrs of Dx best by iCCP3, RFIgA, RFIgM; and 104 proteins differentially expressed & gene analyses showed 21 pathways enriched ≤5 years of Dx. https://t.co/u8abvqNtnX
Dr. John Cush RheumNow ( View Tweet)
Daily purposeful walking assoc w/ lower risk of Knee OA (KOA). UK Biobank study of 89,969 persons, F/U 6.8 yrs - 2711 developed KOA. HRs for incident KOA were 0.84 (0.76-0.92), 0.81 (0.71-0.90), and 0.74 (0.64-0.85) if walking ~5000, ~7000, & ≥8000 steps/d, respectively https://t.co/St9QLuOy9R
Dr. John Cush RheumNow ( View Tweet)
Phase 3 trial shows inebilizumab reduces flares in IgG4-related disease (10% vs 60% in placebo; HR 0.13, p<0.001) and boosts remission rates without background immunosuppressants. CD19+ B-cell depletion shows promise as a new treatment. #Rheum @RheumNow https://t.co/7iSyPfnMV0 https://t.co/M51b0dipMs
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Natasha Salman, DO DrNatashaSalman ( View Tweet)
✅ T2T in #Lupus 👀 ⬇️⬇️
📥 LINK https://t.co/F8w8qRZdsS
#NosVemosEnPANLAR2025 https://t.co/JNx1wdwMb4
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Laurent ARNAUD Lupusreference ( View Tweet)
Our Chief Medical Editor Leonard H. Calabrese, DO, (@LCalabreseDO) shares his reflections on the book: Masterclass in Medicine: Lessons from the Experts
@ClevelandClinic
https://t.co/gZhbrBLcnR
Healio Rheumatology HealioRheum ( View Tweet)
Anti-muscarinic 3 Abs are assoc w/ severe GI Dz in systemic Sclerosis. 132 SSc pts (enrich for GI Sxs) - 39% had anti-M3R Abs; 25% high-titer M3R+. Hi titer M3R+ pts had more diffuse Dz (44% vs 23%), GI severity (91% vs 70%), RNPC3+ (18% vs 6%), U1RNP+(21 vs 2%) https://t.co/j8ZWFY4fgx
Dr. John Cush RheumNow ( View Tweet)
Rheums! Have a rheumatology question or case for Dr. Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology.
https://t.co/uLoRmsAkiG https://t.co/ExthuSBSXs
Dr. John Cush RheumNow ( View Tweet)
RheumNow Live 2025 is now available On Demand
For the first time, https://t.co/4UQlqwujiR is offering exclusive access to:
✅ 7 STEP Talks from top rheumatology experts
✅ 21 Powerful lectures and Q & A Panels answering real-world questions
✅ All speaker slides and handouts https://t.co/saW9WH4djO
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Dr. John Cush RheumNow ( View Tweet)
In a murine model of Kawasaki Dz vasculitis- depleting gut microbiota reduces KD like vasculitis. CV lesions were assoc w/ decrease in Akkermansia muciniphila and Faecalibacterium prausnitzii. Replacement attenuated these findings. https://t.co/Hnij8TWkYy https://t.co/wEuVcuAZ5j
Dr. John Cush RheumNow ( View Tweet)
Systematic review of >90 studies on Pregnancy and RA risk indicates that parity, gravidity, infertility, pregnancy loss do not adversely affect RA development. But low birthweight was assoc w/ RA Dx/severity, and pre-eclampsia incr risk of subsequent RA Dx. https://t.co/jVa4tmSqvj
Dr. John Cush RheumNow ( View Tweet)
Is High Dose Aspirin Needed in Kawasaki Disease (KD)?
Does aspirin add any advantage to intravenous immunoglobulin (IVIG) alone in children with KD? A randomized clinical trial IVIG alone was not inferior to IVIG plus aspirin, suggesting that high-dose aspirin during initial https://t.co/vThkP4AH6x
Dr. John Cush RheumNow ( View Tweet)
Recent Medscape Physician Compensation Report 2025, MD Salaries dropped by:
Dermatology: -11%
Neurology: -6%
Urology: -6%
Plastic surgery: -4%
Cardiology: -4%
Ophthalmology: -4%
Gastroenterology: -3%
Rheumatology: -3% https://t.co/WZDM7XxeEU https://t.co/PhRlHaXsMb
Dr. John Cush RheumNow ( View Tweet)
The IL-17A inhibitor, secukinumab, is in late-stage development forthe treatment of giant cell arteritis and polymyalgia rheumatica. https://t.co/JzzqS7bSjd https://t.co/9Qm0YsJmOL
Dr. John Cush RheumNow ( View Tweet)
FDA reports higher rate of allergic/hypersensitivity type reactions w/ certainlots of Immune Globulin Intravenous (IGIV) and Immune Globulin Subcutaneous (IGSC) ; these have voluntarily withdrawn by the manufacturers https://t.co/j0yVBodLtW https://t.co/k7s4LtLnyu
Dr. John Cush RheumNow ( View Tweet)
Full read state of the art review of treatments for Axial Spondyloarthritis
Concluding unmet needs:
-Suboptimal Tx Response
- Limited Drug Options
- No Biomarkers
- Extra-Axial Dz
- Non-Inflammatory Pain https://t.co/K3oqRCgTCP https://t.co/rkX2givwF8
Dr. John Cush RheumNow ( View Tweet)
Daily purposeful walking assoc w/ lower risk of Knee OA (KOA). UK Biobank study of 89,969 persons, F/U 6.8 yrs - 2711 developed KOA. HRs for incident KOA were 0.84 (0.76-0.92), 0.81 (0.71-0.90), and 0.74 (0.64-0.85) if walking ~5000, ~7000, & ≥8000 steps/d, respectively https://t.co/fwVRRsoQYr
Dr. John Cush RheumNow ( View Tweet)