Methotrexate Monitoring (5.13.2022)

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Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Bad news for digitial ulcers in Systemic sclerosis, Readmissions in Lupus and Thrombocytopenia in APL patients.

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Wiki Guidelines Approach to Pyogenic Osteomyelitis

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A crowd sourced, WikiGuidelines approach to clinical treatment guideline development for pyogenic osteomyelitis yielded 7 important clinical questions, 2 clear treatment recommendations and 5 topic reviews to inform future treatment or investigations.

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Arthritis Predicts Hepatic Fibrosis in Hemochromatosis

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Mayo Clinic Proceedings reports the results of a retrospective, cross-sectional of patients with HFE hemochromatosis showing that advanced hepatic fibrosis is primarily seen in those with arthritis due to HFE hemochromatosis. 

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OP is worse w/ Inflammation; would biologics reduce OP and Fx risk? Swedish study of 24,678 RA pts, 4265 on biologics - Over time, the OP Fx rates were 12.1 vs 13.0 per 1000PY with and without biologics (HR 0.97; 0.78-1.20); Thus no Fx benefit https://t.co/d2zGd0WWoa https://t.co/Z9HVMUQd5U

ACR Guidelines for the Treatment of Systemic Juvenile Idiopathic Arthritis

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The ACR has updated its clinical guidelines for the management of juvenile idiopathic arthritis (JIA), with this update focusing on oligoarthritis, TMJ arthritis, and systemic JIA (with and without macrophage activation syndrome); only the latter, systemic JIA recommendations are reported herein.

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Positive Results from the DOA (Duloxetine in OsteoArthritis) Study

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A pragmatic, open-label trial of osteoarthritis (OA) patients demonstrated that adding duloxetine treatment seems to be beneficial for end-stage knee OA patients with neuropathic-like symptoms (at risk of central sensitization).

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ICYMI: Dr Artie Kavanaugh presents comparison of targeted therapies in different inflammatory disorders. #RWCS2022 @RWCSmtg https://t.co/P4SzIrWzYJ https://t.co/wnf3vnG4xc

Why Would Hand OA Be Less Severe in Black People?

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Osteoarthritis (OA) of the hand was less severe according to objective and pain-related markers in Black patients versus those of other racial/ethnic groups after adjustment for known risk factors, researchers found.

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The July 2021 RheumNow “Live Vote” surveyed US and non-US rheumatologists on their knowledge and practices when dealing with the bone disorder, X-linked hypophosphatemia (XLH).https://t.co/6ztalAZrII https://t.co/ONXaGJI15v

X-Linked Hypophophatemia - Survey Results

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The July 2021 RheumNow “Live Vote” surveyed US and non-US rheumatologists on their knowledge and practices when dealing with the bone disorder, X-linked hypophosphatemia (XLH).

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ICYMI: Annals of Internal Medicine describes a propensity matched comparison study of risedronate and alendronate, showing that, compared to alendronate, risedronate drug holidays were associated with a small increase in risk for hip fractures. https://t.co/6qnMUzqV3E https://t.co/iIrahEuB09

Fracture Risk with Osteoporosis Drug Holidays

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While bisphosphonate drug holidays are recommended, there are few comparative studies.

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Best of 2021: Jack of All Subspecialties

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It's great to be a rheumatologist, but boy, it's getting harder and harder. You have to be a jack of all trades. You have to be good at cardiovascular disease, osteoporosis, vaccination, inflammatory bowel disease - it just never ends. This and more, as Dr. Cush summarizes more than a dozen journal articles, news reports and questions + cases.

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Best of 2021: Tofacitinib Safety Concerns

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Dr. Jack Cush reviews and discusses the news and journal reports from the past week on RheumNow.com.

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Best of 2021: EULAR Guidelines on Intraarticular Therapy

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EULAR has published evidence-based recommendations on the use of intra-articular therapies (IAT) based on the literature review and recommendations of a multidisciplinary international task force. These IAT recommendations apply to adult patients with peripheral arthropathies.

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Geriatric Rheumatology:Improving care of aging patients Dr.Kathryn Dao ( @KDAO2011) moderates a panel w/ Drs.Una Makris, Katherine Wysham, Sebastian Sattui + Devyani Misra, as they discuss aspects of improving care of/outcomes for aging patients. #ACR21 https://t.co/lF3yUZBEkd https://t.co/hYufA8ptqj

Osteoporosis in PsA: Dr. Rachel Tate ( @uptoTate) discusses Abstract #1325, presented at the #ACR21 annual meeting.https://t.co/xnRkPnHeTr https://t.co/nE3ehhCB4j