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Enthesitis precedes the onset of PsA in PsO patients. Dr. @lihi_eder discusses the importance of US in evaluation of these patients.
#RNL2024 @RheumNow https://t.co/bPLR7zpNe2
Dr. Rachel Tate uptoTate ( View Tweet)
@reumacia @RheumNow You are absolutely right. The point was not generally used for psoriasis ( not PsA). I was surprised my self 🤕.
Here is the slide again by Dr. Armstrong , great talk by the way. Let me know if you want the handout. https://t.co/C11Gkn2jho
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Unique and selective allosteric mechanism of deucravacitinib.
Eric Ruderman
#RNL2024
@RheumNow https://t.co/Zm3bYGR9JJ
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Diagnostic delay in SpA
2.3 years longer delay in diagnosis in women with PsA.
@lihi_eder
#RNL2024
@RheumNow https://t.co/d9ao8vvpa5
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Deucravacitinib takes longer to work for PsO compared to UPA, IL-17i or IL23i; it’s better than apremilast. Side effects w/TYK2i: acne, mild⬆️CK, but zoster & lipid issues aren't seen much, & no CV risk warnings; Dr. Strober doesn't follow labs w/TYK2i. #RNL2024 @rheumnow https://t.co/05jKqL4wdx
TheDaoIndex KDAO2011 ( View Tweet)
Clinical pearl from #RNL2024 @RheumNow
Palmoplantar psoriasis is a great time for first-line JAK inhibitor - Ben Strober, Yale dermatology
JAK for atopic dermatitis - extremely rapid responses https://t.co/hHYdGl51n2
Eric Dein ericdeinmd ( View Tweet)
"If you are throwing a JAKi at these patients (see below) you are gonna make them better." Dr. Bruce Strober reporting on potential patients/disease states who may respond to JAKi. #RNL2024 @RheumNow https://t.co/bghPuszu5t
Dr. Rachel Tate uptoTate ( View Tweet)
#RNL2024 @RheumNow
Bruce Strober on JAK in skin diseases - diverse benefits:
- PsO
- Atopic dermatitis
- Alopecia areata
- Hidradenitis suppurativa
- Vitiligo
- Lichen planus any many others https://t.co/I9XHVbFpvQ
Eric Dein ericdeinmd ( View Tweet)
So why should you consider JAKi?
Multiple reasons provided by @JointMD including efficacy in domains, it's PO, reasonable safety.
#RNL2024 @RheumNow https://t.co/BgFjhb18Ad
Dr. Rachel Tate uptoTate ( View Tweet)
Random effect in ACR20 responses in male versus females in PsA.
No sex differences in ACR20 responses in patients on JAK/TYK2i .
@lihi_eder
#RNL2024
@RheumNow https://t.co/fgEORm0nKc
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Sex/Gender disparities in rheumatology.
@lihi_eder
#RNL2024
@RheumNow https://t.co/PB7zPYJHd0
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
More evidence to support role of Tyk2 in management
of skin psoriasis.
Dr.April Armstrong
#RNL2024
@RheumNow https://t.co/9vuuhJMj36
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Impact of obesity on PsA @AlexisOgdie
Weight loss works in PsA:
5 to 10% weight loss lead to OR: 3.7 MDA responses
> 10% of body weight lead even higher odds ( 6.67). #RNL2024
@RheumNow https://t.co/73O0I7uZF4
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Sever psoriatic arthritis / psoriasis by @AlexisOgdie
#RNL2024
@RheumNow https://t.co/KbN7mnHTSd
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Which IL17i to choose? Depends on the domain
Dr. Armstrong: For the skin, the studies show brodalumab, ixekizumab and bimekizumab are superior to secukimumab for #psoriasis
Dr. @AlexisOgdie noted we don't see much differences in these IL17i for the joints.
#RNL2024 @rheumnow
TheDaoIndex KDAO2011 ( View Tweet)
The differences do appear to relate to actual treatment specific differential response. As well as no difference with JAKi, there seems to be no difference in placebo response @lihi_eder @RheumNow #RNL2024 https://t.co/7H4KRvd6WG
Richard Conway RichardPAConway ( View Tweet)
Many advanced treatments appear to work less well in female patients with PsA, but JAKi seem to not demonstrate this phenomenon. Not sure what to do with this data in clinical practice but it is certainly intriguing @lihi_eder @RheumNow #RNL2024 https://t.co/GDrg715ctg
Richard Conway RichardPAConway ( View Tweet)
Dr. Lihi Eder discusses the differences between sex and gender.
Sex is a biologically-based construct defining differences between male and female
Gender has socio-cultural aspects of being a man, woman, or other AND has effect on social norms/expectations
BOTH are important to… https://t.co/iceTS0w5LY https://t.co/slSQMwF91J
Dr. Rachel Tate uptoTate ( View Tweet)
Dr. Lihi Eder discusses the differences between sex and gender.
Sex is a biologically-based construct defining differences between male and female
Gender has socio-cultural aspects of being a man, woman, or other AND has effect on social norms/expectations
BOTH are important to… https://t.co/iceTS0w5LY https://t.co/slSQMwF91J
Dr. Rachel Tate uptoTate ( View Tweet)
Differences in PsA:
Women tend to have higher pain scores with lower pain thresholds and are more likely to report "diffuse pain" compared to men. Keep this in mind with your assessments.
Remember mimics of sacroiliitis including osteitis condensas ilii. Look at the imaging below… https://t.co/AUjkQwfSuk https://t.co/5iXx5cxm4U
Dr. Rachel Tate uptoTate ( View Tweet)