Dr. John Cush RheumNow
4 years 1 month ago
Should you do sural nerve biopsy (SNB) to Dx vasculitis? Study of 91 pts undergoing SNB suggests the SNB must be off sufficient length to improve Dx yield. 40/91 (44%) showed vasculitis. +SNB assoc w/ longer SNB sample, other organ Sxs & +ANCA https://t.co/aSC9xUfRFB https://t.co/lLRnrqXKaw
Dr. John Cush RheumNow
4 years 1 month ago
US national study of shows pregnancy in inflammatory bowel disease pts has higher risks for:
- gestational diabetes (AOR)
- HTN complications (1.35)
- Pre-term births (1.41)
- Fetal growth restriction (1.27)
- Fetal death (3.21)
https://t.co/3XTrrrNmoe https://t.co/udl7dXT5IF
Dr. John Cush RheumNow
4 years 1 month ago
CDC Reviews Monkeypox - 99% men, 94% male-to-male sexual contact; less prodrome; rash (100% including genital), fever (63%), chills (59%), and lymphadenopathy (59%) https://t.co/OUQPXh0RQq
https://t.co/GWpomlj5PX https://t.co/VC6mg35J1Q
Dr. John Cush RheumNow
4 years 1 month ago
150 PsA pts assessed preferences in chosing biologics (of most to less preferred):
1 Oral over SC or IV routes
2 Avoiding severe side effects
3 Resume normal activity
4 Avoid infections
5 Improve enthesitis & 6 psoriasis
7 remission
8 Joint pain https://t.co/kE3qtTWBhH https://t.co/KKcsQqEYKf
Dr. John Cush RheumNow
4 years 1 month ago
Awards issued by ACR, EULAR, BSR Reveal Gender Gap in last 2 decades. While # awards increased (including women), absolute %female prize winners remains lower than males (among 41 total awards). ACR: only ~20% recv top gold medal or Master awards https://t.co/lI548NmeW3 https://t.co/AfRwBANLOE
Dr. John Cush RheumNow
4 years 1 month ago
More Bad Safety News for Xeljanz
Another analysis of the mandatory postmarketing safety study for tofacitinib (Xeljanz) has confirmed what most observers expected: that rates of infection with the drug in RA are higher than with TNF inhibitors.
https://t.co/5FIwRMXdbT https://t.co/8k4NU6Rh6T
Patient-reported fatigue is high in patients with psoriatic arthritis (PsA) and often goes under-recognized by physicians. Fatigue importantly impacts physical functioning, work productivity, and health related quality of life (HRQoL).
A population-based study from Ontario, Canada suggests an increased mortality risk in patients with giant cell arteritis (GCA), according to a recent report in Arthritis Care & Research.
A health administrative data study looked at 22,677 GCA patients (≥50 years of age) compared to an age matched population for mortality rates between 2000 and 2018. Standardized mortality ratios (SMRs) were estimated.
Dr. John Cush RheumNow
4 years 1 month ago
CARRA Registry study of Kids who D/C DMARDs or biologics but flared & restarted meds: the recapture rate was 55% overall (47% oligoarthritis, 69% systemic JIA. By 12 mos 67% of children achieved inactive dz - better odds w/ restarting biologics (OR 2.74) https://t.co/Psgtd0O2jO https://t.co/xsecVRJqOL
Dr. John Cush RheumNow
4 years 1 month ago
Prospective study of 189 new non-infectious anterior uveitis pts, found a high prevalence SpA (56%), 93% w/ axial SpA, few (7) w/ peripheral SpA. 74/106 were newly Dx SpA. SpA predictors: psoriasis (OR 12.5), B27+ (OR 6.3),^CRP (OR 4.8) & male (OR 2.1) https://t.co/uTLmJ2QU1A https://t.co/2rejvp3yTa
Dr. John Cush RheumNow
4 years 1 month ago
Study of diet & RA in 100 new RA & 197 controls; fish/seafood consumption assoc w/ less RA risk (OR 0.52; 0.27–0.98); but processed meat intake yielded increased RA risk (OR 3.45; CI 1.78–6.68). No significant association btw RA and red meats or poultry https://t.co/wLpHfA50mY https://t.co/p2EOLBKrwW
Dr. John Cush RheumNow
4 years 1 month ago
JAK Inhibitors in Difficult Still’s Disease
A small retrospective study suggests that patients with difficult to treat AOSD or sJIA may respond well to JAKi agents - presumable by blocking pro-inflammatory cytokines, notably IL-6 and IFN.
https://t.co/cH9wb8bPTX https://t.co/Xm7DUC5okk
Dr. John Cush RheumNow
4 years 1 month ago
Lilly has announced that Taltz (ixekizumab) is now available as a Citrate-Free Formulation to reduce injection site pain for patients with psoriasis, psoriatic arthritis, spondyloarthritis & nonradiographic axial spondyloarthritis. https://t.co/kFQVUdalQp https://t.co/UKtFzReIe6
MMWR recently reviewed the epidemiology and characteristics of U.S. monkeypox cases seen between May and July 2022. They found that 99% of cases occurred in men, 94% of whom reported recent male-to-male sexual or close intimate contact. Current outbreak-associated cases are less likely to have a prodrome and more likely to have genital involvement and racial and ethnic minority groups appear to be disproportionately affected.
Dr. John Cush RheumNow
4 years 1 month ago
Amgen and ChemoCentryx, (maker of newly approved Avacopan)have entered into a definitive agreement wherein Amgen will acquire ChemoCentryx for ~$3.7 billion ($52 per share). https://t.co/8quO9ET8vH https://t.co/AphPizgKo8

