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Believing is Doing (1.21.2022)
Dr. Jack Cush reviews the news and journal articles from this past week on RheumNow.com. These reports are about better outcomes in Lupus; fewer Gout flares with T2T and the power of belief. 
ARD has publish a prospective, multicenter, observational study of vaccination outcomes in antineutrophil cytoplasmic antibodies associated vasculitis (AAV) patients, showing that AAV patients may not be adequately protected after standard two-dose COVID-19 vaccination, but that a third vaccine dose of BNT162b2 induced a strong neutralising antibody activity against B.1.617.2 in most individuals.
The CDC's Advisory Committee on Immunization Practices (ACIP) recently recommended and approved two doses of the recombinant zoster vaccine (RZV, AKA Shingrix) for prevention of herpes zoster and complications in immunodeficient or immunosuppressed adults aged ≥19 years.
Who is Your Glue?

Surely you have used or heard of “<the person> who was the glue that held the family together

Dr. John Cush RheumNow

4 years 8 months ago
Who is Your Glue? Surely you have used or heard of “<the person> who was the glue that held the family together”. Read on… https://t.co/CRaWDQaZvk https://t.co/q8KFcxzzDG
ONE MILLION DOWNLOADS!

We are excited to announce Dr.Cush and the RheumNow podcast recently hit one million downloads!

Dr. John Cush RheumNow

4 years 8 months ago
ONE MILLION DOWNLOADS! We are excited to announce Dr.Cush and the RheumNow podcast recently hit one million downloads! Thank you to all of our listeners-we appreciate you coming back week after week. Find us each week where ever you get your podcasts. https://t.co/AOJCMGZClJ https://t.co/3ImftCnqzw
The next generation of lupus therapies (esp in lupus nephritis) - belimumab, voclosporin , anifrolumab, obinutuzumab. B

Dr. John Cush RheumNow

4 years 8 months ago
The next generation of lupus therapies (esp in lupus nephritis) - belimumab, voclosporin , anifrolumab, obinutuzumab. Better trial designs, better organ endpoints, but yet these trials/results are limited by the high dose steroids in play.... https://t.co/48D9rI9EEH
RT @EricTopol: How's the United States doing on boosters?
Trailing a long list of countries, including Serbia, Slovenia,

Eric Topol EricTopol

4 years 8 months ago
How's the United States doing on boosters? Trailing a long list of countries, including Serbia, Slovenia, and Lithuania @OurWorldInData https://t.co/cOCVoyuqT3
UTSW Rheum Grand Rounds
New and concerning: sJIA associated lung disease - rare and associated w/ pulmonary HTN, alveola

Dr. John Cush RheumNow

4 years 8 months ago
UTSW Rheum Grand Rounds New and concerning: sJIA associated lung disease - rare and associated w/ pulmonary HTN, alveolar proteinosis, high mortality. Unique features: clubbing, eosinophilia, TCZ anaphylaxis, Trisomy 21. Most were Rx w/ IL-1 > IL-6 inhibition @UTSWRheum https://t.co/aJaPurDSmJ
UTSW Rheum Grand Rounds - Dr. Nigrovic shows the efficacy of long acting IL-1 inhibition (canakinumab) and IL-6 (tociliz

Dr. John Cush RheumNow

4 years 8 months ago
UTSW Rheum Grand Rounds - Dr. Nigrovic shows the efficacy of long acting IL-1 inhibition (canakinumab) and IL-6 (tocilizumab) in systemic JIA patients @UTSWRheum https://t.co/XdG8pAq1c4
UTSW Rheum Grand Rounds
Treating STill's (sJIA) - early early use of anakinra yields best results (in remission and off

Dr. John Cush RheumNow

4 years 8 months ago
UTSW Rheum Grand Rounds Treating STill's (sJIA) - early early use of anakinra yields best results (in remission and off steroids) - 91% if Anakinra started within the first 3 mos @UTSWRheum https://t.co/neozpYhJtM
UTSW Rheum Grand Rounds
MAS occurs in 2-8% of Systemic JIA pts and has a high mortality (&lt;40%); It is more frequent w

Dr. John Cush RheumNow

4 years 8 months ago
UTSW Rheum Grand Rounds MAS occurs in 2-8% of Systemic JIA pts and has a high mortality (<40%); It is more frequent w/ onset in Years 1-4. Treatment - steroids, anakinra, etoposide or CsA & Rx infxn if present. Oh...dont stop the anakinra! @UTSWRheum https://t.co/09uQm3LURC
UTSW Rheum Grand Rounds
IL-18 levels are elevated in systemic JIA, MAS and AOSD @UTSWRheum https://t.co/pIYKf4pods

Dr. John Cush RheumNow

4 years 8 months ago
UTSW Rheum Grand Rounds IL-18 levels are elevated in systemic JIA, MAS and AOSD @UTSWRheum https://t.co/pIYKf4pods
Dr. Peter Nigrovic asserts the division between pediatric and adult arthritis is senseless and has no firm biologic basi

Dr. John Cush RheumNow

4 years 8 months ago
Dr. Peter Nigrovic asserts the division between pediatric and adult arthritis is senseless and has no firm biologic basis. Instead we should consider pts as sero- positive or negative, Systemci or Spondyloarthropathy. @UTSWRheum https://t.co/zx5oQmUQ6Y
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