Dr. John Cush RheumNow
5 years ago
ICYMI:
https://t.co/wM1iRxtHvk
The interleukin-6 inhibitor, tocilizumab (TCZ), was studied in a cohort of difficult systemic sclerosis (SSc) and was shown to be effective in refractory joint and skin disease with good long-term retention rates and disease stabilization. https://t.co/A8dfCksp3b
Dr. John Cush RheumNow
5 years ago
A retrospective study of systemic sclerosis patients shows that acute hospitalization and mortality were not uncommon and were often linked to SSc-related lung disease.
#RheumNow
https://t.co/s5wSlndTrt https://t.co/KHz9LYZVAK
Dr. John Cush RheumNow
5 years ago
J Hopkins study of 524 myositis-specific Ab positive pts shows that while 91% met 2017 EULAR/ACR criteria for Dx of myositis, 20% of HMGCR+ & 50% anti-PL7 did not classify as myositis; ~10% anti-SRP & HMGCR were dx as inclusion body myositis https://t.co/jcIn6SzbGG
This week: high science that affect future treatments; breakthrough infections in our patients, and what's up with that; and soon your radiologist is going to be replaced by AI. This and more in our review of the news and journal articles from the past week.
Dr. John Cush RheumNow
5 years ago
NOVEL: CRISPR-Cas9 genome editing of stem cells allows sensing of local inflammation & proportionally secrete a programmed anti-inflammatory biologic drug. Stem cells implanted in cartilage can prevent pain and inflammatory damage https://t.co/VNIgnvDU2C
Dr. John Cush RheumNow
5 years ago
MMP13 is one of several key contributors to #OA. Novel research showing the IA depot of nanoparticles w/ small interfering RNAs targeting MMP13 (breaks down type II collagen) can reduce cartilage damage/loss in mouse model of post-traumatic OA https://t.co/3wy6Bdk4o0
Dr. John Cush RheumNow
5 years ago
Differential Dx of immune-mediated necrotizing myopathies (IMNM) - HMGCR & Signal recognition particle Abs; checkpoint inhibitors, anti-Mi2 dermatomyositis, antisynthetase syndr. antimitochondrial Abs, GVHD, SARS-CoV-2 infection https://t.co/hhizx5gAet
The FDA has again extended its decision on whether the manufacturers of vaping products can market their e-cigarettes in the United States.
Previously, the manufacturers (Juul, Vuse and Blu) were given until September 2020 to submit data to the FDA on the use and safety of these vaping products, but were given a one year grace period without FDA enforcement, while the agency reviewed their applications.
A retrospective study of systemic sclerosis patients shows that acute hospitalization and mortality were not uncommon and were often linked to SSc-related lung disease.
Record review of 95 SSc patients from a single-centre cohort seen between 2010 and 2020 found that over half (53 patients) required acute hospitalization, with a total of 164 admissions.
The most frequent causes for hospitalization:
Dr. John Cush RheumNow
5 years ago
Among patients with rheumatoid arthritis (RA), the strongest risk factors for the development of lymphoma were disease activity and severity, French researchers found. #RheumNow
https://t.co/mEYtTl2WRs https://t.co/KTluamv9gj
Dr. John Cush RheumNow
5 years ago
Analysis of records from the Mass General Brigham healthcare system in the Boston area, shows that breakthrough infections (after receiving SARS-CoV-2 vaccines) in patients with SARDs are not uncommon, and may be severe or fatal.
https://t.co/Ri5QipR7YY https://t.co/TaTFTKfAzm
Dr. John Cush RheumNow
5 years ago
Cardiac coronary Ca score (CCS) in 20 asymptomatic systemic sclerosis (SSc) pts vs controls.CCS incr (& higher scores) in 45% SSc vs 10% controls. CCS values higher in Limited vs diffuse SSc. CCS > 100 assoc w/ age, dz duration obesity https://t.co/aDWpoePqXK
Aaron Goodman - “Papa Heme” AaronGoodman33
5 years ago
When MGUS isn't MGUS!
(MGCS, C = Clinical)
Literally, every MGUS consult I consult this
https://t.co/JymQ8A8V2U
+ urticaria = Schnitzler's
+ ataxic neuropathy+opthalmoplegia= CANOMAD
+⬆️RBC+pulm shunt+telangiectas = TEMPI
+ bleed = aVWD, amyloid (⬇️X)
+ cap leak = Clarkson
... https://t.co/m1qpWo4xjh
Rheumatology Advisor RheumAdvisor
5 years ago
Among patients with acute #gout flare, early vs late initiation of #allopurinol did not show significant changes in time to resolution, flare recurrence, or inflammatory makers. #Rheumatology
https://t.co/PhJNbOjWbp

