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News Feature: Psoriatic Pregnancies Pose Risks to the Mother, Not Child

https://t.co/kZE2yLEvm7

Dr. John Cush RheumNow

5 years 5 months ago
News Feature: Psoriatic Pregnancies Pose Risks to the Mother, Not Child https://t.co/kZE2yLEvm7
News Feature: Dual IL-17 Targeting is Effective but has More Candidiasis

https://t.co/uDNx65PcC4

Dr. John Cush RheumNow

5 years 5 months ago
News Feature: Dual IL-17 Targeting is Effective but has More Candidiasis https://t.co/uDNx65PcC4
JAMA Dermatology features a case of EGPA - 50 yoM with pruritic rash (legs and arms), asthma, high fevers. His medical

Dr. John Cush RheumNow

5 years 5 months ago
JAMA Dermatology features a case of EGPA - 50 yoM with pruritic rash (legs and arms), asthma, high fevers. His medical history included uncontrollable asthma, WBC 22.9K, marked eosinophilia (9860), neg ANCA, ANA, etc. Bx= LCV w/ Eos. Rx w/ Pred https://t.co/TqANjKV2T9
A metanalysis of pregnancy outcomes in women with psoriasis and psoriatic arthritis finds an excess risk of adverse maternal events, but not adverse neonatal events. This systematic review included 16 studies meeting inclusion criteria.  Overall they found that pregnant women with psoriatic diseases have higher risk of adverse maternal outcomes vs the general population:
Bimekizumab (BIM) is a monoclonal antibody that targets both interleukin-17A and interleukin-17F, which as a biologic target has worked well in the management of psoriatic disease. The current issue of the NEJM has two reports wherein BIM was shown to be more effective than secukinumab and adalimumab in treating patients with moderate-to-severe plaque psoriasis; however, safety concerns arise. 
Take a look at our COVID-19 section of the site to see all articles published on this virus.

https://t.co/TiB7739ONL

Dr. John Cush RheumNow

5 years 5 months ago
Take a look at our COVID-19 section of the site to see all articles published on this virus. https://t.co/TiB7739ONL
Drug interactions w/ JAK inhibitors - Retrospective analysis of 152,853 pts found ~10% that could have interaction w/ st

Dr. John Cush RheumNow

5 years 5 months ago
Drug interactions w/ JAK inhibitors - Retrospective analysis of 152,853 pts found ~10% that could have interaction w/ strong OAT3 inhib (<0.1%), CYP3A4 (3%) or CYP3A4 and CYP2C19 inhib (11%) (like lovastatin, prozac, amiodarone, EES, Diflucan) https://t.co/tZztU6cddb
Expansive differential diagnosis list of Spondyloarthritis/Sacroiliitis Mimics. Free read from Frontiers of Medicine; E

Dr. John Cush RheumNow

5 years 5 months ago
Expansive differential diagnosis list of Spondyloarthritis/Sacroiliitis Mimics. Free read from Frontiers of Medicine; Early imaging is key to early diagnosis but may lead to misdiagnosis too. https://t.co/N3Vm0MxH9m https://t.co/hxBa065CMV
Analysis of Taiwans National Health Insurance Database, shows from 4.5 children (&lt;18yrs), 23% received steroid burst

Dr. John Cush RheumNow

5 years 5 months ago
Analysis of Taiwans National Health Insurance Database, shows from 4.5 children (<18yrs), 23% received steroid burst < 14 days (URI, allergies, asthma) and shows higher 30 rates of GI Bleed (IRR 1.4), Sepsis (2.02), & pneumonia (2.19) https://t.co/ReuNP1C8ww
A randomized clinical trial of patients with CMC1 osteoarthritis shows modest benefits when a combination of conservative treatments (education, splinting, hand exercises, 1% diclofenac sodium gel) was used compared to education alone. While there were small to medium benefits with regard to hand function, there was no benefit in pain outcomes. 
The GO-AHEAD study was designed to assess the long-term efficacy and safety of golimumab (GLM) in non-radiographic axial spondyloarthritis (nr-axSpA).  After the 16-week, placebo [PBO]-controlled double-blind phase, 189/198 (95.5%) entered the long-term extension (OLE) for 36 weeks wherein GLM patients continued on GLM (GLM/GLM) and PBO treated patients were then given GLM (PBO/GLM).
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