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RA & SpA in remission - if you taper biologic or JAK, what happens to infection risk = Nothing! Metanalysis of 13 studies 2260 pts in remission f

Dr. John Cush RheumNow

6 years 5 months ago
RA & SpA in remission - if you taper biologic or JAK, what happens to infection risk = Nothing! Metanalysis of 13 studies 2260 pts in remission finds no diff in serious infx rate in taper group(1.7/100PY) vs usual care(2.6/100PY)(p=0.13); no diff in SAE! https://t.co/FqXyVOKLs7
TNR Journal Club - Withdrawal of Steroids in Lupus
Journal Club with Dr. Artie Kavanaugh
NYC, NYU COVID infected Rheum pts (n 86 RA, PsA, AS, PsO, IBD);
16% Hospitalized. Hosp pts were more likely to be older, w/ HTN, DM, COPD, on Pred, HC

Dr. John Cush RheumNow

6 years 5 months ago
NYC, NYU COVID infected Rheum pts (n 86 RA, PsA, AS, PsO, IBD); 16% Hospitalized. Hosp pts were more likely to be older, w/ HTN, DM, COPD, on Pred, HCQ, MTX, but less likely to be on JAKi, biologic, TNFi (vs ambulatory) https://t.co/UCVndBDc7r https://t.co/ZEk1PFEkXA
ACR has published COVID-19 Recs -American College of Rheumatology Guidance for the Management of Adult Patients with Rheumatic Disease During the COVI

Dr. John Cush RheumNow

6 years 5 months ago
ACR has published COVID-19 Recs -American College of Rheumatology Guidance for the Management of Adult Patients with Rheumatic Disease During the COVID‐19 Pandemic by Mikuls Johnson Fraenkel Arasaratnam Baden Bermas Chatham https://t.co/wwpslcLXx2
The oral cannabinoid receptor type 2 (CB2) agonist lenabasum showed promising results for systemic sclerosis (SSc) in a phase II study.
The Annals of Rheumatic Disease has published the preliminary recommendations of the German Society of Rheumatology for the management of Inflammatory rheumatic diseases patients during the SARS-CoV-2/Covid-19 pandemic. These preliminary recommendations are based on an expert consensus from 17 experienced German rheumatologists.
"It is not enough that we do our best; sometimes we must do what is required."
- Winston Churchill

Dr. John Cush RheumNow

6 years 5 months ago
"It is not enough that we do our best; sometimes we must do what is required." - Winston Churchill
The world has been turned upside down in the last 6 weeks. Medicine and rheumatology have certainly changed – a frightening experience for Chicken Little, a disaster for the pessimist, a challenge for the pragmatist and an opportunity for the optimists amongst us. Last week I asked our audience to tell me their “upside or downside of COVID-19”. Read on to see how your peers have operating or thinking.
HCQ fails to prevent severe COVID19 in 17 SLE pts (w/ CKD, GN, APL, 12 pred, 7 on immunosuppressants).14 hospitalized, 13 viral pneumonia, 11 respirat

Dr. John Cush RheumNow

6 years 5 months ago
HCQ fails to prevent severe COVID19 in 17 SLE pts (w/ CKD, GN, APL, 12 pred, 7 on immunosuppressants).14 hospitalized, 13 viral pneumonia, 11 respiratory failure, 5 ARDS; 3 ARF. Despite good HCQ levels, 2 died, 5 on ventilator, 36% D/C, 1/2 still hosp. https://t.co/e0qLGtF6Nj
“It does not matter how slowly you go as long as you do not stop.” ― Confucius

Dr. John Cush RheumNow

6 years 5 months ago
“It does not matter how slowly you go as long as you do not stop.” ― Confucius
Pediatricians are asking the question - could this be a rare manifestation of COVID-19 in children? There are now 3 case reports in the U.S of children infected with the coronavirus who have developed what looks like Kawasaki's diseaes.  Simimar reports have been seen in the UK, Italy and Spain.
In the last few days there have been encouraging "preliminary" reports that IL-6 inhibition by either tocilizumab or sarilumab may be efficacious in patients with severe coronavirus infections.
French retrospective study of 429 pts (302 SpA, 127 PsA) compared 203 on TNF inhib mAb vs 226 on etandercept as 1st TNFi. The probability of uveitis

Dr. John Cush RheumNow

6 years 5 months ago
French retrospective study of 429 pts (302 SpA, 127 PsA) compared 203 on TNF inhib mAb vs 226 on etandercept as 1st TNFi. The probability of uveitis during the 1st yr was lower with ETA but not signif different than mAbs (OR 0.94; 0.35; 2.54) https://t.co/jCSxL0hh7H https://t.co/cCSyVqgd6w
Matched case control study of 94 SLE patients with diffuse alveolar hemorrhage finds Lupus nephritis, +SSA, thrombocytopenia & high CRP were indep

Dr. John Cush RheumNow

6 years 5 months ago
Matched case control study of 94 SLE patients with diffuse alveolar hemorrhage finds Lupus nephritis, +SSA, thrombocytopenia & high CRP were independent risk factors for DAH. SLE-DAH pts had signif higher mortality (adjHR 6.0; 2.8–13.0). https://t.co/OUtSqXTGnw https://t.co/3myioyHqvc
"Permanence, perseverance and persistence in spite of all obstacles, discouragements, and impossibilities: It is this, that in all things distinguishe

Dr. John Cush RheumNow

6 years 5 months ago
"Permanence, perseverance and persistence in spite of all obstacles, discouragements, and impossibilities: It is this, that in all things distinguishes the strong soul from the weak." - Thomas Carlyle
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