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A new scientific review of 148 studies enrolling over 4.3 million adult chronic pain patients treated with prescription opioid painkillers has found that nearly one in ten patients experiences opioid dependence or opioid use disorder and nearly one in three shows symptoms of dependence and opioid use disorder.
Dr. Madelaine Feldman has written an important commentary on the 340B Drug Pricing Program, a safety-net program that would allow vulnerable populations to receive expensive new therapies. But she points out that "this well-intentioned program has strayed from its original purpose", allowing certain hospitals and for-profit pharmacies to exploit the program.
Efficacy and Safety of Nipocalimab for Sjogren's Syndrome

Dr. Mike Putman reports on abstract 2527, Efficacy and Safet

Dr. John Cush RheumNow

1 year 7 months ago
Efficacy and Safety of Nipocalimab for Sjogren's Syndrome Dr. Mike Putman reports on abstract 2527, Efficacy and Safety of Nipocalimab, an Anti-FcRn Monoclonal Antibody, in Primary Sjogren’s Disease: Results from a Phase 2, Multicenter, Randomized, Placebo-Controlled,… https://t.co/kkIOCUZRml https://t.co/nL47c5veCp
Steroids do NOT hamper muscle Bx dx of ANCA vasculitis. Tokyo study of 126 pts w/ suspected vasculitis had Quad muscle B

Dr. John Cush RheumNow

1 year 7 months ago
Steroids do NOT hamper muscle Bx dx of ANCA vasculitis. Tokyo study of 126 pts w/ suspected vasculitis had Quad muscle Bx; 71 (+) w/ Dx of AAV. Bx yield in 56 and 15 pts w/ off or on steroids, respectively, was similar (59% vs 53%). https://t.co/Xpt01Wksd3 https://t.co/NSBclcEgwq
Metanalysis of 41 studies, & 5343 AAV pts showed 55% (2890) had infection; 36% w/ severe infxn. This included PJP,

Dr. John Cush RheumNow

1 year 7 months ago
Metanalysis of 41 studies, & 5343 AAV pts showed 55% (2890) had infection; 36% w/ severe infxn. This included PJP, aspergillosis, candidiasis, HZ, CMV, etc. Pulmonary most common. Risk factors included older, ESRD, DM, smoking, Renal or lung involvement https://t.co/4TtnP5wGc4 https://t.co/RatBXPUk7a
Rheumatoid Arthritis Boosts Risk for Some Types of Heart Failure

Rates of heart failure with preserved ejection fracti

Dr. John Cush RheumNow

1 year 7 months ago
Rheumatoid Arthritis Boosts Risk for Some Types of Heart Failure Rates of heart failure with preserved ejection fraction (HFpEF) were doubled in patients with rheumatoid arthritis (RA) relative to other people of the same age and sex, researchers found.… https://t.co/t7GRp7c63x https://t.co/Ov6UwGlPko
Abstract 1731 is a small RCT of baricitinib in inflammatory myositis comparing early start baricitinib to later start.
Japanese registry study of CV & CA outcomes in #RA. CV (MACE) events = IR 0.49/100 PY.
Cancer= IR 0.78/100PY. MACE

Dr. John Cush RheumNow

1 year 7 months ago
Japanese registry study of CV & CA outcomes in #RA. CV (MACE) events = IR 0.49/100 PY. Cancer= IR 0.78/100PY. MACE risk factors: Male, age≥65, HTN, Renal or cerebrovascular Dz; CA risk w/ Male, age, NSAID, COPD, SIE, CA Hx. https://t.co/uBFbho25La https://t.co/3ClEwCvdDY
A Spanish Collaborative Group study of Tocilizumab (TCZ) in Giant Cell Arteritis (GCA) demonstrated high efficacy regardless of the different vascular phenotypes treated. 
Biosimilars Do Impact Biologic Drug Costs
  • MedPage Today
Introduction of biosimilars for the rheumatology drug adalimumab, whose original branded version Humira has long been a blockbuster, appears to have led to a dramatic drop in net spending for these products -- even though biosimilars barely dented Humira prescription rates.
1st MTX use in 242 Italian pts w/ chronic inflam arthritis (54% RA, 33% PsA, 16% UA). Overall, survival of MTX at 24 mo

Dr. John Cush RheumNow

1 year 7 months ago
1st MTX use in 242 Italian pts w/ chronic inflam arthritis (54% RA, 33% PsA, 16% UA). Overall, survival of MTX at 24 months was 60%, (40% @48 mos, 20% @96 mos). MTX survival in RA & PsA equal, but superior to UA (undiff. arthritis) https://t.co/g4pZpVmTnM https://t.co/gcKWriqfhG
Serum IL-40 increased in RA (vs OA, SLE, Controls) and correlates with some clinical characteristics. IL-40 did not cor

Dr. John Cush RheumNow

1 year 8 months ago
Serum IL-40 increased in RA (vs OA, SLE, Controls) and correlates with some clinical characteristics. IL-40 did not correlated w/ Dz activity, but was pos. assoc. w/ RA autoAbs, coagulation-related indicators, and decreased with TNFIi Rx. https://t.co/leBPKbNpf5 https://t.co/fHU8lcS4eW
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