Depressing finding re:glucocorticoid discontinuation in SLE No improvement over decades in rate of GC discontinuation; if anything, we start more GC than ever @AliDuarteMD help me out here; why haven't we made more progress? #ACR24 @RheumNow Abstr#2421 https://t.co/uzZATKPWVC

• https://x.com/EBRheum/status/1858543437903004159/photo/1
• https://x.com/EBRheum/status/1858543437903004159/photo/1
• https://x.com/EBRheum/status/1858543437903004159/photo/1

A study evaluating the effectiveness of Direct-to-Patient (D2P) screening for psoriatic arthritis (PsA) in psoriasis patients. Key findings: - 30% response rate from 825 patients; 13% screened positive. - 75% of referrals deemed appropriate, with one-third receiving a new PsA… https://t.co/bcQN6KkC8m https://t.co/zogI2PYvtO

• https://x.com/i/web/status/1858544445156962383
• https://x.com/synovialjoints/status/1858544445156962383/photo/1

Cardiology is on! Dr. Olin discusses Fibromuscular Dysplasia findings on imaging Definite: string of beads and/or focal narrowing in right setting / location Possible but nonspecific: dissection, ecstasia, aneurysm, and tortuously @RheumNow #ACR24 https://t.co/Dr81KQfLSf

• https://x.com/Dr_Brian_MD/status/1858544477818020126/photo/1

Why is there female predominance in #SLE - the extra X chromosome in females (XX) may not be inactivated properly- usually maintained by the long non-coding RNA #Xist #ACR24 abst#2599 @RheumNow https://t.co/C9Qj5zSnpN

• https://x.com/bella_mehta/status/1858545451533770863/photo/1

Updated ACR guidelines on management of lupus nephritis (LN). Consider early biopsy. Focus on triple therapy in LN. From the panel discussion, Tacrolimus can be an alternative to CNI (Voclosporin) where there is no access to this. Manage comorbidities such as CV risk, bone… https://t.co/4R02YnRXDP https://t.co/3J7YcF5ucQ

• https://x.com/i/web/status/1858545592370188704
• https://x.com/synovialjoints/status/1858545592370188704/photo/1

Galloway et al. 117,050 individuals. VTE risk in RA consistently increased, irrespective of age, sex, BMI. Risk VTE 46% higher in RA! @RheumNow #ACR24 Abstr#1901 https://t.co/SQPcPiBeF2 https://t.co/BQkERUsGlL

• Venous Thromboembolism Risk Is Consistently Increased in People with Rheumatoid…
• https://x.com/RichardPAConway/status/1858545954540175534/photo/1

Abstract 1842: Off the shelf CAR T therapy No lymphodepletion needed, delivering robust, targeted CD19+ B cell elimination in multiple in vitro assays @RheumNow #ACR24

Do pts w autoimmune disease (AID) respond differently to immune checkpoint inhibitors (ICI) & have different mortality or iRAE risk vs pts without AID? Study of pts on ICI showed no significant difference in mortality in pts w & without pre-existing AID Ab2532 #ACR24 @RheumNow https://t.co/suywDdGIB1

• https://x.com/DrMiniDey/status/1858534127064019181/photo/1

Applying the guidelines to Cases- Dr M Dall’Era for a pt wit extrarenal lupus and active LN. #ACR24 @rheumnow https://t.co/lvOUWjEdEz

• https://x.com/KDAO2011/status/1858534463073861691/photo/1
• https://x.com/KDAO2011/status/1858534463073861691/photo/1
• https://x.com/KDAO2011/status/1858534463073861691/photo/1
• https://x.com/KDAO2011/status/1858534463073861691/photo/1

Non-pharm tx in TAK - not something we always think about but… Impressive effect of resistance exercise!! Not just in symptoms but also inflammatory markers Per Dr. Springer - even a stress ball could be enough for UE vascular health in these pt @RheumNow #ACR24 https://t.co/3O46gobbMX

• https://x.com/Dr_Brian_MD/status/1858534823310069933/photo/1
• https://x.com/Dr_Brian_MD/status/1858534823310069933/photo/1

The updated 2024 ACR Guideline for Dx and Tx of #lupus nephritis is here! Dr. Lisa Samaritano discusses the key recommendations 👇 For all pts: screen for LN, give HCQ and RAAS for pts with ⬆️ proteinuria GCs in pts w/ LN class III/IV &/or V. @Rheumnow #ACR24 @rheumarhyme https://t.co/wLVRGktR59

• https://x.com/RHEUMarampa/status/1858534848090021939/photo/1
• https://x.com/RHEUMarampa/status/1858534848090021939/photo/1

The overview for #lupus nephritis tx. Triple therapy is preferred as first line due to: 1. RCTs (BLISS-LN & AURORA 1) showing improved outcomes w/ triple txs 2. Nephron loss happens with ongoing LN - time is kidney! @RheumNow #ACR24 https://t.co/IQo3q3O1pt

• https://x.com/RHEUMarampa/status/1858534869514523055/photo/1
• https://x.com/RHEUMarampa/status/1858534869514523055/photo/1

Overall very reasonable, aligning ACR recs w/other guidance groups & updated data Remember: guidelines are meant to be broken. Some patients can likely avoid pulse, others may need more steroid on the back end, biopsies are not benign #ACR24 @RheumNow

Recommend "Triple Therapy" = Glucocorticoids + two other agents Practically, that means MMF + belimumumab OR CNI for most pts For the CYC afficionados, the lower-dose EUROLUPUS protocol is preferred #ACR24 @RheumNow https://t.co/0gRISXSw0c

• https://x.com/EBRheum/status/1858535181373563219/photo/1

Happening now, new guidelines for mgmt. A few highlights: Recommend prompt GC therapy, pulse x1-3d followed by oral pred (<0.5mg/kg/d) w/taper to <5mg by 6 months Aligns with EULAR recs for a much-lower dose than most clinicians currently doing #ACR24 @RheumNow https://t.co/B71i7FBYlQ

• https://x.com/EBRheum/status/1858535178517303725/photo/1