Since chronic kidney disease is one of the strongest CV risk factors, any new strategy to reduce proteinuria and avoid a decline in renal function may likely improve patient outcomes. In large cardiovascular outcome trials, the use of a fairly new-kid-on-the-block therapy, sodium–glucose cotransporter-2 inhibitors (SGLT2i) appear to be both cardio and renal-protective. Would the use of SGLT2i have the same impact in SLE?
The last day at ACR23 was a ghost town as most left, largely because there was limited programming on the fourth and final day. The main attraction on Day 4 was the late-breaking abstract – oral presentations. Here’s a list of the late breakers; below, I provide commentary on the ones that caught my attention.
Dr. John Cush RheumNow
2 years 11 months ago
#ACRbest Abstracts – Day 2
Our reporters have been prolific in finding the hot abstracts, those that were most attended or those that are getting the most buzz on social media. Here are RheumNows #ACRbest abstract reports from Monday, 11/13 at #ACR23.
https://t.co/yIYYI7IVBD https://t.co/86Nt1mVha8
Dr. John Cush RheumNow
2 years 11 months ago
Monitoring the Effect of Upadacitinib Therapy with a Smart Watch?
https://t.co/z6durHZ57R https://t.co/wSJiWNOx9M
Dr. John Cush RheumNow
2 years 11 months ago
Lupus Topic Panel
Featuring panelists Dr. Kathryn Dao, Eric Dein and Sheila Reyes, discussing the best and most interesting lupus studies presented at #ACR23.
https://t.co/QWR17kOkHD https://t.co/jpaUI2X2Fc
Dr. John Cush RheumNow
2 years 11 months ago
Will CAR T Cells also treat RA?
Dr. Jonathan Kay reports on abstract 0424 from #ACR23
https://t.co/xPMmVNZdAC https://t.co/8b3AmjzvML
Dr. John Cush RheumNow
2 years 11 months ago
Methotrexate: shall we split up?
Methotrexate (MTX) is widely used in rheumatic diseases yet poses common tolerance issues, especially for the oral form; and bioavailability is known to be limited for doses over 15mg.
https://t.co/txCIkgtvzP https://t.co/Mk8FLy4jO3
Dr. John Cush RheumNow
2 years 11 months ago
How do we manage difficult discussions about pregnancy in RA?
Most rheums know that it is important to get pregnancy planning right for women of childbearing age living with rheumatic diseases. That is easier said than done, though...
https://t.co/cXtqqVv6fp https://t.co/k5afTUKYf8
ARD & RMD Open ARD_BMJ
2 years 11 months ago
L20 at #ACR23
Phase 3 RCT of #Telitacicept vs. placebo in #RA
☝🏻B-cell neutralization by targeting BlyS and APRIL
✅ better ACR20 and 50 response at W24
✅ favorable structural response
✅ good safety profile
❓ few seronegative patients
A new small molecule to treat #RA?
PAJ https://t.co/fyrqAya41e
Elena MyasoedovaMD ☀️
2 years 11 months ago
#ACR23 #EdLovering presenting on association b/w #RA, #CVD & #Dementia:
👉🏻CVD is not a signif mediator b/w RA &Dementia
👉🏻 signif synergy b/w RA & CVD on dementia (HR 2.45 vs those w/o RA&CVD)
👉🏻 ⬆️ risk of dementia in RA mostly in people with RA+CVD
#Mayoclinicrheumatology https://t.co/5kqs3HAACn
Nigil Haroon MD, PhD, DM, FRCPC, FRCP, MBA NigilHaroon
2 years 11 months ago
The dynamic Dr. Vinod Chandran, talking about metabolomics in #psoriaticDisease
#ACR23
The metabolomics facility was established recently at the @UHN @UofT @SchroederInst and we are already seeing the results. @KrembilF @CRASCRRheum @UofTRheum https://t.co/Azxq3k8w5g
Jeffrey Sparks MD MMSc jeffsparks
2 years 11 months ago
Impressive and important study supporting safety of TNF inhibitors among patients with RA-ILD. Elegant methods of target trial emulation. Congrats to the authors on plenary presentation!
#ACR23 https://t.co/P7keAoOX7M
The Lancet Rheumatology TheLancetRheum
2 years 11 months ago
🔥 HOT OFF THE PRESS for #ACR23
Effectiveness of a fourth dose of #COVID19 mRNA #vaccine in patients with systemic autoimmune rheumatic diseases using DMARDs: an emulated target trial https://t.co/bvc75BP4aG @zach_wallace_md @jeffsparks https://t.co/CAlgjvUr9X

