Narratives around polymyalgia rheumatica (PMR) often centre around “older people” or even “elderly”. And, indeed, the peak of the age distribution is in the mid-70s – not that everyone that age considers themselves old. Treating “young PMR” can be a very different proposition to treating someone in their seventies or eighties. It’s worth taking time to think this through.
Dr. John Cush RheumNow
3 years ago
Unpopular opinion: spinach can be bad for you
The title might have misled you; simply, Dr Stephen Paget’s analogy comparing the drastic response to steroids in #PMR to Popeye’s spinach stuck with me!
https://t.co/VNlY6O5YeE https://t.co/RZmbVL2EiZ
Dr. John Cush RheumNow
3 years ago
Methotrexate in OA
Dr. Jack Cush discusses the news, journal articles and regulatory actions. This week we discuss JAKne, DLE and SLE and more.
https://t.co/RHiRBxajc6 https://t.co/PCygEXKT8f
Dr. John Cush RheumNow
3 years ago
Subcutaneous Remsima, an infliximab biosimilar, has been FDA. Celltrion has rebranded this as Zymfentra, for maintenance therapy in adults with moderately to severely active Ulcerative colitis and Crohn's disease following (after giving IV infliximab) https://t.co/gvcssRuB92 https://t.co/dPYVi10KIA
The ACR has published its updated recommendations for prevention and treatment of glucocorticoid-induced osteoporosis (GIOP) for patients receiving >3 months treatment with glucocorticoids (GCs) ≥2.5 mg daily.
Despite increasing treatment options to prevent and treat GIOP, many GC-treated patients are not evaluated or treated.
Dr. John Cush RheumNow
3 years ago
Korean Insurance matched (1:10) claims cohort study (2010-2017) found bronchiectasis in 5.3% of 4845 systemic sclerosis pts vs 1.9% of non-SSc controls (24,225). SSc pts have a signif higher risk of bronchiectasis (adj HR 2.63), thus a minor feature of SSc https://t.co/7oOBkpw2DM https://t.co/683I0mMmQI
Dr. John Cush RheumNow
3 years ago
What Goes Wrong with the Immune System in #PMR?
Polymyalgia rheumatica (PMR) is a common inflammatory rheumatic disease. Imaging studies have revealed that PMR should not be viewed as a mysterious source of pain and stiffness.
https://t.co/bQDcpM1ymQ https://t.co/B5anJolukY
Dr. John Cush RheumNow
3 years ago
#PMR TNR Pearls
Lessons learned from this months Tuesday Nite Rheumatology (TNR) sessions.
https://t.co/HiYcHL52hO https://t.co/z0xuYODLXV
As the sole effective treatment for polymyalgia rheumatica since their development in the 1950’s until recently, the impact of glucocorticoids and PMR outcomes are undeniably intertwined. So much so that when the OMERACT PMR working group first set out to develop a PMR core outcome set, they quickly realised that many of the outcomes important to patients were related to their glucocorticoid use.
Dr. John Cush RheumNow
3 years ago
FDA Approves Bimekizumab for Plaque Psoriasis
UCB announced today that the FDA has approved bimekizumab-bkzx (Bimzelx)) for the treatment of moderate to severe plaque psoriasis in adults who needing systemic therapy or phototherapy.
https://t.co/BqeSAAxtQb https://t.co/LFjzkmAC5w
Dr. John Cush RheumNow
3 years ago
Using Methotrexate in #PMR
Where in other inflammatory rheumatic disorders, such as RA and PsA, early initiation of MTX is common practice, this is not the case in PMR. Treatment of PMR is still largely based on GC.
https://t.co/fW9BL3YWS5 https://t.co/bQwozOPUvJ
Dr. John Cush RheumNow
3 years ago
2023 EULAR Lupus Management Recommendations
EULAR has published updated recommendations for the management of systemic lupus erythematosus (SLE) based on new evidence and expert opinion - formulationg five overarching principles and 13 recommendations.
https://t.co/LainTFQBDg https://t.co/4b4h1fy6M3
Dr. John Cush RheumNow
3 years ago
JAKne? Systematic review &meta-analysis (25 studies, 10 839 pts), JAK inhibitor use was associated with an elevated odds of acne (OR 3-5 for UPA, TOFA, BARI, Deucra; but higher for abrocitinib (OR 13.5). Seen in Derm pts but hardly at all in Rheum pts https://t.co/En8HCqwqjO https://t.co/ak216wmlBA
Dr. John Cush RheumNow
3 years ago
Genetic links for Raynauds Phen (RP): Large GWAS study of 5147 RP cases in the UK Biobank cohort shows 2 robust and strong (p < 4.8 × 10−13) novel loci A) ADRA2A (rs7090046, OR per allele: 1.26) & B) IRX1 (rs12653958, OR: 1.17) as candidate causal genes https://t.co/W6F736uskO https://t.co/u1IZnIy7wg

