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A novel trial has shown that combination biologic therapy (guselkumab plus golimumab) to be more effective in ulcerative colitis than either biologic alone.
PsA: Depressing News on Second- and Later-Line Treatments

Most patients with PsA failed to achieve low disease activit

Dr. John Cush RheumNow

3 years 6 months ago
PsA: Depressing News on Second- and Later-Line Treatments Most patients with PsA failed to achieve low disease activity after switching from one targeted therapy to another, real-world data from Scandinavian registries indicated. https://t.co/7tSzoNLVoD https://t.co/3oUM4E38b1
Treat-to-Target Guidelines for GCA and PMR

The Annals of Rheumatic Disease has published updated multinational, T2T rec

Dr. John Cush RheumNow

3 years 6 months ago
Treat-to-Target Guidelines for GCA and PMR The Annals of Rheumatic Disease has published updated multinational, T2T recommendations for the treatment of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR). https://t.co/OQmtqGGNQu https://t.co/eEOTWfdgLI
Prospective study of 490 mod-to-severe psoriasis compared prospectively by exam & US for PsA - 384 w/o arthritis (Si

Dr. John Cush RheumNow

3 years 6 months ago
Prospective study of 490 mod-to-severe psoriasis compared prospectively by exam & US for PsA - 384 w/o arthritis (Silent PSO), 80 non-PSO & 106 w prodromal or active PsA (12.7%). US synovio-enthesitis in 1.8% of controls & 16.1% of silent PSO (p< 0.001) https://t.co/kUdIwLnfYL https://t.co/dgIaOXaJKR
CorEvitas registry data shows H2H comparison of 369 CCP+ abatacept &amp; 475 CCP+ tofacitinib treated patients showe

Dr. John Cush RheumNow

3 years 6 months ago
CorEvitas registry data shows H2H comparison of 369 CCP+ abatacept & 475 CCP+ tofacitinib treated patients showed equivalent drug responses (reduced CDAI or PRO's); b/tsDMARD naive pts had numerically better ABA response at 6 mos (P = 0.662) https://t.co/36jr7l2DKm https://t.co/PItYrvMUNV
Granulomatous Myositis? Back to Square One

Samuel Ng, MD, presents his poster at RWCS 2023.

https://t.co/7dcbUbRe8b ht

Dr. John Cush RheumNow

3 years 6 months ago
Granulomatous Myositis? Back to Square One Samuel Ng, MD, presents his poster at RWCS 2023. https://t.co/7dcbUbRe8b https://t.co/9lobNJOkJd
While anifrolumab targets IFN alfa in SLE, its unclear how much IFNa is needed for Rx response. A study of 40 pts shows

Dr. John Cush RheumNow

3 years 6 months ago
While anifrolumab targets IFN alfa in SLE, its unclear how much IFNa is needed for Rx response. A study of 40 pts shows Rx naive SLE has signif higher serum IFN activity; this is assoc w/ fever, leukopenia, ALE rash and oral ulcers & more organ damage https://t.co/RtI9ulurB1 https://t.co/wMl5DOyGB6
Yesterday, the U.S. Food and Drug Administration (FDA) approved sarilumab (Kevzara) for the treatment of adults with active, refractory polymyalgia rheumatica (PMR), stipulating it is indicated in those patients who have had an inadequate response to corticosteroids or who cannot tolerate corticosteroid taper.
Phase 3 Trials of Baricitinib Disappoint in SL

Despite the encouraging phase II trial results of baricitinib in SLE pat

Dr. John Cush RheumNow

3 years 6 months ago
Phase 3 Trials of Baricitinib Disappoint in SL Despite the encouraging phase II trial results of baricitinib in SLE patients, two parallel phase III trials have failed to redemonstrate the efficacy of baricitinib in active SLE. https://t.co/JjouppdG8k https://t.co/SHATPuTIiP
Korean study Neonatal/maternal outcomes w/ NSAIDs. 1.8 million pregn assoc w/ early preg NSAIDs exposure - incr risks fo

Dr. John Cush RheumNow

3 years 6 months ago
Korean study Neonatal/maternal outcomes w/ NSAIDs. 1.8 million pregn assoc w/ early preg NSAIDs exposure - incr risks for major congenital malformations (adjRR 1.14), low birth Wt (1.29) & maternal oligohydramnios (1.09); higher w/ COX-2i or NSAIDs>10d https://t.co/SaRrVOHOt9 https://t.co/b2YqUh91fK
FDA has approved sarilumab (Kevzara) for the treatment of polymyalgia rheumatica (PMR) in adult patients who have had an

Dr. John Cush RheumNow

3 years 6 months ago
FDA has approved sarilumab (Kevzara) for the treatment of polymyalgia rheumatica (PMR) in adult patients who have had an inadequate response to corticosteroids or who cannot tolerate corticosteroid taper. Approval is based on Phase 3 SAPHYR study https://t.co/kA9pTauvDP https://t.co/GGlyvQcyat
Check out last week's podcast--we discuss interesting data on the risk of arthritis comes from a large NHANES study.

h

Dr. John Cush RheumNow

3 years 6 months ago
Check out last week's podcast--we discuss interesting data on the risk of arthritis comes from a large NHANES study. https://t.co/w5TNhH7a2f https://t.co/bkKDoWA0ft
An Alternative Pain Protocol Following Knee Replacement Surgery

A study reports that a novel surgical pain management s

Dr. John Cush RheumNow

3 years 6 months ago
An Alternative Pain Protocol Following Knee Replacement Surgery A study reports that a novel surgical pain management strategy following total knee arthroplasty (TKA), or total knee replacement, provided pain relief without opioids. https://t.co/OMQ4Tjl8Yv https://t.co/Hu59WJohcN
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