Variability of Guidelines on the Perioperative Use of DMARDs in Rheumatic Diseases Patients

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More effective treatments in patients with rheumatic diseases have resulted in less need for major surgery, yet a substantial number of RMD patients will undergo surgery often in the setting of DMARDs use. A scoping review looked at numerous clinical practice guidelines/recommendations for the perioperative management of DMARDs and found inconsistencies and low quality evidence, with great reliance on conditional (expert opinion) recommendations.

Osteoporosis treatment benefits people older than 80

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People who are older than 80 should be considered for osteoporosis treatment after a fracture to avoid further risk, according to a study being presented Saturday at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco, Calif.

Interstitial Lung Disease and Lung Cancer Risk

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A large prospective cohort study found that interstitial lung disease (ILD) is associated with an increased risk of lung cancer.

Hmmm Really? (7.11.2025)

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Dr. Jack Cush reviews the news and journal reports from this past week - some obvious, other new thoughts and some - hmmm, reallly?

CMS to Test Prior Authorization Model in Traditional Medicare

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The Centers for Medicare & Medicaid Services (CMS) announced a new experimental model late last week to streamline some prior authorizations under the traditional Medicare program, but some politicians and experts are concerned that it could result in more delays in care.

No Increased Malignancy Risk with Ixekizumab

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A pooled analysis of 25 randomized clinical trials affirms the safety of ixekizumab (IXE) when used to treat patients with psoriasis (PsO), psoriatic arthritis (PsA), or axial spondyloarthritis (axSpA).

Overview of the VEXAS Syndrome

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A current systematic review in Rheumatology addresses the clinical features seen in the VEXAS syndrome.

Cancer Survival Outcomes in Autoimmune Skin Disease Patients

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Patients with autoimmune skin diseases (ASDs) with cancer had significantly better cancer survival outcomes than those without ASD, suggesting coexistant autoimmune or inflammatory disease does not adversely affect a cancer prognosis.

Reducing Progression of Psoriasis to Psoriatic Arthritis

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Tumor necrosis factor (TNF) inhibitor therapy was effective in reducing the likelihood that psoriasis would progress to psoriatic arthritis (PsA), a retrospective study indicated.

Early DMARD Initiation Benefits in Psoriatic Arthritis

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Mease et al has published the results of a cohort study showing early initiation of disease-modifying antirheumatic drugs (DMARDs) in patients with psoriatic arthritis (PsA) resulted in better outcomes compared to late initiation.

Immunomodulators in the Treatment of Autoimmune Hepatitis

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Autoimmune hepatitis (AIH) is a chronic, progressive inflammatory liver disease driven by autoimmune mechanisms, characterized by elevated serum aminotransferases, hypergammaglobulinemia, and interface hepatitis on histology.

ICYMI: SLE: advances to achieve deep B-cell depletion

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The race is on for the first chimeric antigen receptor (CAR)-based therapy to be approved for the treatment of systemic lupus erythematosus. Its main principle is to induce deep B-cell depletion, with the hope to reset the B-cell aberrant immunity for a sustained clinical remission. At EULAR 2025 in Barcelona, several advances of CAR-based therapies will be presented.