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Tocilizumab vs. Methotrexate in Rheumatoid Arthritis

A large randomized rheumatoid arthritis (RA) clinical trial compared subcutaneous tocilizumab (TCZ) vs oral methotrexate (MTX) vs. the combination of subcutaneous TCZ and MTX, and showed that TCZ was superior to MTX, either given as TCZ monotherapy or in combination with MTX. 

To evaluate the efficacy and safety of subcutaneous tocilizumab monotherapy, tocilizumab-methotrexate, and methotrexate alone for patients with RA.

No Cancer Recurrence with Biologic DMARDs in RA

A prospective Danish rheumatoid arthritis (RA) registry study look at the risk of recurrence when a biological disease-modifying antirheumatic drugs (bDMARDs) was ued in patients with a a prior solid cancer (in remission) and found no increased cancer recurrence risk. 

Pregnancy planning, contraception and safe drugs in Pregancy. Featuring Dr. Megan Clowse, Durham NC https://t.co/sZu

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Dr. John Cush
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Pregnancy planning, contraception and safe drugs in Pregancy. Featuring Dr. Megan Clowse, Durham NC https://t.co/sZuq475VJv https://t.co/HZv9FuviaR

SLE, Antiphospholipid Antibodies, and the Placenta It is well established that women with SLE are at increased risk fo

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Dr. John Cush
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SLE, Antiphospholipid Antibodies, and the Placenta It is well established that women with SLE are at increased risk for adverse pregnancy outcomes, including preeclampsia, preterm birth, and pregnancy loss. However, the pathophysiologic mechanisms driving these complications https://t.co/f8Up1112m9
Is Lupus Just a B Cell Disorder?

I'm very happy to give you some insights entitled, “Is Lupus a B-Cell Disorder”. I will review some aspects, mainly pros and cons, but at the end you may forgive me, I will escape a little bit from a clear yes or no.

Moving Targets in Lupus and Lupus Trials
Clinical trial data quality is a moving target. Lupus is also a moving target. Can we address the moving target of lupus pathology with the moving targets of quality clinical trials and scientific treatment selection?
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