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Antiphospholipid Syndrome

What is your preferred 1st line treatment for newly diagnosed antiphospholipid syndrome?

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When suspecting antiphospholipid syndrome what labs do you order most?

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What is the influence of the ANA in patients with APL syndrome?

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T/F: SLE patients who test positive for aPL Abs are at higher risk of diffuse alveolar hemorrhage.

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T/F: Hydroxychloroquine lowers thrombotic risks in aPL Ab (+) patients.

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Who usually manages aPL patients and anticoagulation?

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T/F: Multiple aPL autoantibody tests must be positive to establish the diagnosis.

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In your symptomatic aPL patients, how do you monitor?

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An LAC(+) 35 y/oF is 8 wks. pregnant – She has Hx of 2 early miscarriages. How would you treat this patient?

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APS with recurrent thrombosis despite therapeutic INR (2.0–3.0 on warfarin), which of the following is the next best step?

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I am a...:

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Periprosthetic femoral Fx (PPFF): metanalysis of 36 studies found PPFF risk factors: Uncemented stems (OR 3.36), major t

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Dr. John Cush
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Periprosthetic femoral Fx (PPFF): metanalysis of 36 studies found PPFF risk factors: Uncemented stems (OR 3.36), major teaching hosp (2.0), female (1.6), obesity (1.4), Hi comorbidity(1.4), RA (1.89), (1.67), revised THR (2.6). OA = protective (0.51) https://t.co/y2BpH8LUb6 https://t.co/hX2lcjI4Kg
Steroids in Lupus Nephritis: No Free Lunch
Today I'm here to talk with you about steroids in lupus nephritis. The impetus for this is the 2024 ACR guideline for the management of lupus nephritis.

Lupus in an empty house The full house immunofluorescence pattern is the classic histopathologic finding of lupus and

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Dr. John Cush
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Lupus in an empty house The full house immunofluorescence pattern is the classic histopathologic finding of lupus and lupus nephritis. Glomerular deposits staining for IgG, IgA, IgM, C3 and C1q can help confirm a suspected diagnosis of systemic lupus erythematosus (SLE). This https://t.co/DQWwRJmdqM

Assessing and Treating CV Risk Increases in Systemic Lupus For nearly 50 years, the heightened CVD risk in SLE patient

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Dr. John Cush
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Assessing and Treating CV Risk Increases in Systemic Lupus For nearly 50 years, the heightened CVD risk in SLE patients has been acknowledged since Urowitz et al.'s 1976 study on lupus mortality. Research consistently shows SLE patients have a 2-10 times higher CVD risk than https://t.co/P1AdxHkiQi
Biologics in Pregnancy Patients With Autoimmune Disease

A large cohort, claims data study shows that among pregnant women receiving biologic therapies for autoimmune conditions, 72% continued their biologics pregnancy, more so among inflammatory bowel disease (IBD) patients than those with rheumatoid arthritis (RA), psoriasis (PsO) or psoriatic arthritis (PsA).

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