Christina Charles-Schoeman, Patrick Zueger, Erin McDearmon-Blondell, Siran Fang, Yi Peng, Manish Jain, John Tesser
Abstract or description:In this analysis of administrative health care claims and electronic medical record data (2016–2023), treatment response was evaluated among patients with rheumatoid arthritis (RA) on a first-line tumor necrosis factor inhibitor (TNFi). The study included patients with moderate/high disease activity (MDA/HDA) at TNFi initiation who remained on first-line TNFi for ≥12 months. Treatment response was defined per the Clinical Disease Activity Index (CDAI) as low disease activity (LDA) or remission (CDAI≤10). Following first-line TNFi initiation, 34.1% of patients (n/N=414/1215) achieved LDA/remission at 3 months, and 40.8% (n/N=563/1381) achieved LDA/remission at 6 months. Among patients in MDA/HDA at 6 months, 80% remained in MDA/HDA at 12 months. Thus, the majority of those who did not achieve an initial TNFi response also did not achieve a subsequent response at 12 months.
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