28 February 2025

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Opioid deaths are down, IL-33 levels are up and Weight loss is in the news again this week!

Opioid Deaths are Down (2.28.2025)

CDC reports an unprecedented drop of ~24% in US drug overdose deaths (87,000 down from 114,000) in 12 mos prior to 9/24.

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CDC reports an unprecedented drop of ~24% in US drug overdose deaths (87,000 down from 114,000) in 12 mos prior to 9/24. Yet, overdose remains the leading cause of death for Americans aged 18-44 yrs https://t.co/REiaQx6NKd https://t.co/nzOMDgUYbS

Links

CDC Reports Nearly 24% Decline in U.S. Drug Overdose Deaths https://buff.ly/4hRUfjR

27 February 2025

Loss of Good Sleep Linked to All-Cause Mortality

A US study shows that nearly two-thirds of the population had suboptimal 5-year sleep duration trajectories with a resultant 29% increase in risk of all-cause mortality.

Schnitzler Syndrome: A Rare Autoinflammatory Disorder A credible, quick overview Chronic Urticaria Monoclonal Gammopath

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Schnitzler Syndrome: A Rare Autoinflammatory Disorder A credible, quick overview Chronic Urticaria Monoclonal Gammopathy ( Recurrent Fever Bone & Joint Pain Elevated CRP &ESR https://t.co/boYFFEVwII https://t.co/xKCUZb8o6A

Links

Schnitzler Syndrome: A Rare Autoinflammatory Disorder https://buff.ly/4h734oy

The global biosimilars market size is evaluated at USD $40 billion in 2025 and is expected to hit approximately USD 176

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The global biosimilars market size is evaluated at USD $40 billion in 2025 and is expected to hit approximately USD 176 billion by 2034 (a 17.78% increase) https://t.co/U4PbinVN4J https://t.co/SLHynlhJrs

Links

Biosimilars Market Size Estimated to Reach USD 175.99 Billion by 2034 https://buff.ly/4h7fm01

27 February 2025

Recurrent Pericarditis in Lupus

A study from the Lupus Hopkins Cohort shows that systemic lupus erythematosus (SLE) patients with pericarditis are at risk for recurrence, and likely to be younger patients, with uncontrolled disease, and linkage to higher doses of oral prednisone.

This retrospective analysis of a single-center prospective cohort of SLE patients seen between 1988 and 2023, analyzed those with pericarditis, their predictors and features. Recurrence was defined as episodes occurring at least 6 weeks after the first episode.

Diagnoses via Immune ‘Fingerprints’ Science and researchers at Stanford Medicine have reported the use of Mal-ID (

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Diagnoses via Immune ‘Fingerprints’ Science and researchers at Stanford Medicine have reported the use of Mal-ID (machine learning for immunological diagnosis) to analyze B and T cell receptors (BCRs and TCRs) sequences from human blood, showing the ability to predict health… https://t.co/ni09ssCYSv https://t.co/4HWui3XxfE

Postoperative Weight Loss Improves Joint Replacement Survival A cohort study of shows that postoperative weight loss w

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Postoperative Weight Loss Improves Joint Replacement Survival A cohort study of shows that postoperative weight loss with antiobesity medications significantly reduced the risk of 5-year and 10-year revision among patients with obesity undergoing hip or knee replacement.… https://t.co/u04Lc6DTT0 https://t.co/iZhEICFHUd

Cross-trait study of >300K patients’ electronic health records at UCSF and Stanford. Autoimmune conditions associa

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Cross-trait study of >300K patients’ electronic health records at UCSF and Stanford. Autoimmune conditions associate with greater Alzheimer’s risk (ORs 1.4–1.7). Women with autoimmune disorders have higher risk than men with autoimmune disorders https://t.co/bwtGhyNBs6 https://t.co/FNUdRNozCw

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Exposure to autoimmune disorders is associated with increased Alzheimer’s disea… https://buff.ly/4iia5UJ

Topics

Opioid Deaths are Down (2.28.2025)

CDC reports an unprecedented drop of ~24% in US drug overdose deaths (87,000 down from 114,000) in 12 mos prior to 9/24.

Schnitzler Syndrome: A Rare Autoinflammatory Disorder A credible, quick overview Chronic Urticaria Monoclonal Gammopath

The global biosimilars market size is evaluated at USD $40 billion in 2025 and is expected to hit approximately USD 176

Diagnoses via Immune ‘Fingerprints’ Science and researchers at Stanford Medicine have reported the use of Mal-ID (

Postoperative Weight Loss Improves Joint Replacement Survival A cohort study of shows that postoperative weight loss w

Cross-trait study of >300K patients’ electronic health records at UCSF and Stanford. Autoimmune conditions associa

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