23 September 2025

CAR-T Product Shows Early Promise in Lupus

Five patients with systemic lupus erythematosus (SLE) in China have been treated with a potentially groundbreaking form of chimeric antigen receptor (CAR) T-cell therapy, researchers reported, with encouraging results after 3 months.

Post hoc analyses of (FUTURE 5) 541 active PsA pts Rx w/ secukinumab shows NO radiographic progression through 2 years o

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Post hoc analyses of (FUTURE 5) 541 active PsA pts Rx w/ secukinumab shows NO radiographic progression through 2 years of SEC was assoc with achieving LDA at Week 104. https://t.co/ZeI9z4Civa https://t.co/LCI6kZ1z0v

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Relationship of radiographic progression status to low disease activity in pati… https://buff.ly/uAFMfD1

Did Hydroxychloroquine Reduce COVID-19 Mortality? A multicenter study investigated the association between hydroxychlo

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Did Hydroxychloroquine Reduce COVID-19 Mortality? A multicenter study investigated the association between hydroxychloroquine (HCQ) dosage and COVID-19 mortality among hospitalized patients from multiple medical centers in China. The analysis focused on dose effects of HCQ on https://t.co/BuHoMDwpuP

Comparative Frequency of Systemic autoimmune rheumatic diseases (SARDs) in Australia: - SLE 57.9 per 100K - Lupus neph

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Comparative Frequency of Systemic autoimmune rheumatic diseases (SARDs) in Australia: - SLE 57.9 per 100K - Lupus nephritis 11.2 per 100K - SSc 25.6 per 100K - ANCA-associated vasculitis 10.8 per million PYs https://t.co/cx9LvswQ2E https://t.co/ltcXCw23bI

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https://buff.ly/lan7RL4

23 September 2025

High-Resolution CT in CTD-Interstitial Lung Disease

A systematic review and meta-analysis examined the role of high-resolution computed tomography (HRCT) in diagnosing and characterizing interstitial lung disease (ILD) associated with connective tissue diseases (CTDs). The study analyzed 23 studies published between 2015-2024, encompassing 2020 patients with CTD-ILD across five major CTDs: systemic sclerosis (SSc), rheumatoid arthritis (RA), Sjögren's syndrome (SS), idiopathic inflammatory myopathies (IIMs), and mixed connective tissue disease (MCTD).

Report of 54 Sjögren dz pts w/ cutaneous vasculitis (CV); most had cryoglobulinemic vasculitis & hypergammaglob.vas

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Report of 54 Sjögren dz pts w/ cutaneous vasculitis (CV); most had cryoglobulinemic vasculitis & hypergammaglob.vasculitis. Sjogrens w/ CV had higher risk of lymphoma. Type II cryoglob. vasculitis incr risk of mortality/lymphoma, renal dz, peripheral nerve involvement https://t.co/7UPFd2dSZU

22 September 2025

Methylprednisolone plus Methotrexate in Giant Cell Arteritis

What is the optimal glucocorticoids (GC) regimen in giant cell arteritis (GCA)? Does methotrexate (MTX) work in GCA?

A multicenter trial from Spain shows equivalent outcomes when GCA patients were treated with a combination of intravenous methyl-prednisolone (IVMP) pulse plus MTX compared to GC alone (standard of care/SOC). They concluded that combination IVMP/MTX with lower-dose prednisone is as effective as the SOC, but had less overall GC exposure.

Sucutaneous anifrolumab? Phase III TULIP-SC trial in SLE patients showed SC anifrolumab (Saphnelo) significantly reduct

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Sucutaneous anifrolumab? Phase III TULIP-SC trial in SLE patients showed SC anifrolumab (Saphnelo) significantly reducted lupus disease activity compared to placebo. https://t.co/vvI2av2vAJ https://t.co/0V1wsmFk0N

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Saphnelo self-administration TULIP-SC Phase III trial meets primary endpoint in… https://buff.ly/meaC7fM

Single-center retrospective study 49 pts w/ primary angiitis CNS (PACNS) stratified by vessel size. Vessel size dx by im

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RheumNow

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Single-center retrospective study 49 pts w/ primary angiitis CNS (PACNS) stratified by vessel size. Vessel size dx by imaging & neuroradiologists. Small vessel involv(n  9) was significantly assoc w/ +Biopsies, CTX use, functional decline & more relapses. https://t.co/DF6DknoPxY https://t.co/puc6nvEAut

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https://buff.ly/XzT6Mzj

Systematic review of 139 RCTs(9644 pts) & 12 Rx options for knee OA (KOA) shows simple Rx is best. For pain and func

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RheumNow

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Systematic review of 139 RCTs(9644 pts) & 12 Rx options for knee OA (KOA) shows simple Rx is best. For pain and function, knee brace was best, followed by exercise, and US worst. For total WOMAC best was hydrotherapy, then exercise & LaserTx. (Short wave diathermy worst) https://t.co/sN9TxJGn6N

Topics

CAR-T Product Shows Early Promise in Lupus

Post hoc analyses of (FUTURE 5) 541 active PsA pts Rx w/ secukinumab shows NO radiographic progression through 2 years o

Did Hydroxychloroquine Reduce COVID-19 Mortality? A multicenter study investigated the association between hydroxychlo

Comparative Frequency of Systemic autoimmune rheumatic diseases (SARDs) in Australia: - SLE 57.9 per 100K - Lupus neph

Report of 54 Sjögren dz pts w/ cutaneous vasculitis (CV); most had cryoglobulinemic vasculitis & hypergammaglob.vas

Sucutaneous anifrolumab? Phase III TULIP-SC trial in SLE patients showed SC anifrolumab (Saphnelo) significantly reduct

Single-center retrospective study 49 pts w/ primary angiitis CNS (PACNS) stratified by vessel size. Vessel size dx by im

Systematic review of 139 RCTs(9644 pts) & 12 Rx options for knee OA (KOA) shows simple Rx is best. For pain and func

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