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Metabolic

Comorbidities Impact Disease Activity in Spondyloarthritis

Sep 13, 2020

An analysis of a large population-based cohort of axial spondyloarthritis (axSpA) patients shows that comorbidities are common and are associated with higher disease activity and higher levels of functional impairment.

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Do NSAIDs Increase Cardiovascular Risk in Osteoarthritis?

Aug 26, 2020

A longitudinal study of administrative data from British Columbia shows that nonsteroidal antiinflammatory drugs (NSAIDs) use increases the risk of cardiovascular disease (CVD) among osteoarthritis (OA) patients.

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RheumNow Podcast – The Bad News That’s Fit to Print (8.21.20)

Aug 20, 2020

Dr Jack Cush reviews the news and journal reports from the past week on RheumNow: filgotinib rejection, delays in diagnosis, metformin benefits COVID, Abx and IBD, and UPA beats MTX.

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Diabetes is a risk factor for COVID mortality; yet Metformin dramatically lowers mortality in a preprint, unreviewed paper - retrospective EHR review of 25,326 subjects COVID tested at UAB; metformin signif reduced mortality risk in DM w/ COVID (OR 0.33) https://t.c

Dr. John Cush RheumNow ( View Tweet)

Aug 17, 2020
RA is associated with a 24‐35% lower risk of type 2 diabetes. Claims data comparison of 449,327 RA, general non‐RA, hypertension, OA, or PsA patients finds a lower risk of T2DM in RA (7/1000PY) and highest w/ HTN (12.3/1000PY) https://t.co/uZn5qaImO9

Dr. John Cush RheumNow ( View Tweet)

Aug 06, 2020

2020 ACR Gout Management Guideline

Jul 03, 2020

In May, the American College of Rheumatology (ACR) released the"2020 Guideline for the Management of Gout"reflecting new clinical evidence since the last guideline published in 2012.



The guideline puts forth 42 recommendations, including 16 strong recommendations, based in 52 PICO

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#EULAR2020 #op0192 UK Biobank and IMPALA studies: metabolic body composition of PsA pts w/increased VAT,ectopic liver fat distribution & ⬆️ abdominal fat index associated w/increased risk of CHD&T2DM @RheumNow https://t.co/CwwAB2yUid
Olga Petryna DrPetryna ( View Tweet)
Jun 07, 2020

RheumNow Podcast – In Times of Trouble (4.24.20)

Apr 24, 2020

Dr Jack Cush reviews the news, journal reports, twitter feed and COVID developments from the past week on RheumNow.com

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Lower Risk of Diabetes with Abatacept

Apr 20, 2020

 Patients with rheumatoid arthritis (RA) treated with abatacept (Orencia) had a lower risk of developing diabetes mellitus compared with those receiving certain tumor necrosis factor (TNF) inhibitors, a large cohort study suggested.

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Updates on Psoriatic Arthritis at ACR 2018

Dr. Philip Gardiner
Mar 05, 2020

I think 2018 was the year that belonged to psoriatic arthritis (although some may argue in favor of immune conditions induced by Checkpoint inhibitors). Many years ago the late Professor Verna Wright in Leeds (UK) was a lone voice for many years describing the clinical subtypes of Psoriatic

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A Role for SGLT2 Inhibition in Gout?

Dec 17, 2019

The antidiabetic medication canagliflozin (Invokana) lowered serum urate and reduced the risk of gout flare in a post-hoc analysis of data from two large clinical trials.

In the CANVAS clinical trial program, which was funded by Janssen Research & Development and included more than

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ACR 2018 - Day 1 Report

Oct 11, 2019

Highlights from Tuesday and Wednesday (days 3 and 4) from the ACR annual meeting include: the important and impactful abstracts covered by the Rheumatology Roundup session; upadacitinib clinical trials; and the baricitinib CV and VTE safety analysis.

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Need for Pre-operative Hyperglycemia Testing Prior to Total Joint Replacement

Sep 10, 2019

JAMA reports on a large Medicare cohort study showing that amongst patients undergoing total joint replacement (TJR), preoperative HbA1c testing was performed in 26% to 43% of patients with diabetes and in only 5% of those without diabetes. Importantly research has shown that an elevated HbA1c

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Weight Loss Cuts Hospital Stays for Obese TKA Patients

Sep 04, 2019

Morbidly obese patients who lost 20 lbs before total knee arthroplasty (TKA) cut their hospital stays by about 1 day, and were 76% less likely to have an extended hospital stay, research showed. 

However, morbidly obese patients who lost between 5 and 10 lbs before the surgical

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A Potential Biomarker for Chronic Fatigue Syndrome Patients

Jul 17, 2019

Myalgic encephalomyelitis/chronic fatigue syndrome affects at least 2 million people in the United States and bears tremendous overlap with fibromyalgia - both being difficult to diagnosis because the symptom complex is often unrecognized and these conditions have no biomarker test. 

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RheumNow Podcast – Gout Spot Light (1.11.19)

Jan 11, 2019

Dr. Jack Cush discusses the highlights from the past week on RheumNow.com:

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Sleep Apnea Increases Gout Risk

Jan 02, 2019

Both Gout and obstructive sleep apnea (OSA) comingle with a wide range of serious comorbidities. A matched retrospective cohort study from the UK Clinical Practice Research database shows those with OSA are at a higher risk of developing gout.

This report compared 15,879 patients with

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Pre-Diabetes Associated Risk for Arthritis, Obesity and Physical Inactivity

Nov 13, 2018

The current MMWR reports that arthritis is seen in nearly one-third of adults with prediabetes and that more than half of such patients are obese and not engaged in regular physical activity.

Doctor-diagnosed arthritis affects 54.4 million in the U.S. and the CDC expects this to rise to

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Activity Trackers May be Helpful in Arthritis Patients

Oct 04, 2018

Use of wearable activity trackers was associated with increases in the number of daily steps among individuals with rheumatic and musculoskeletal disorders, a meta-analysis found.

In seven studies that assessed the number of daily steps during a mean study duration of 13.9 weeks, the

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Dietary Recommendations for Psoriatic Disease

Aug 21, 2018

A systematic review by the Medical Board of the National Psoriasis Foundation examined the role of diet in managing adult patients with psoriasis and/or psoriatic arthritis and suggest that dietary interventions to reduce disease severity.

A metanalysis of 55 studies and 4534 patients

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Severity of Lupus Nephritis is Declining over Time

May 08, 2018

A retrospective follow-up study of 499 lupus nephritis (LN) patients over three successive eras shows that LN has become less severe in recent years and thus, better long-term survival is possible.

A multicenter, Italian study examined LN patients over a 46-year period, dividing eras

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Rising Need for Weight Loss Counseling in Arthritic Patients

May 07, 2018

The CDC's May 4th MMWR reports that from 2002 to 2014, the prevalence of health care provider counseling for weight loss among adults with arthritis and overweight or obesity increased by 10% (from 35% to 45%).

Among the 54.4 million adults with doctor-diagnosed arthritis in the United

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Increased Comorbidity Burden in Lupus African Americans

Apr 11, 2018

Researchers from Vanderbilt University Medical Center used electronic health records (EHR) to perform a phenome-wide study comparing African American (AA-SLE) and Caucasian (C-SLE) with systemic lupus erythematosus (SLE) and found more comorbidities in AA-SLE, especially renal, cardiovascular

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Leflunomide May Sensitize the Insulin Receptor and Have an Anti-Glycemic Effect

Mar 05, 2018

An animal model study in the Journal of Endocrinololgy reports the potential use of leflunomide in the control of hyperglycemia in male mice. 

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Diet During Pregnancy May Influence Future Allergic or Autoimmune Disease

Mar 01, 2018

A systematic review of the literature on the relationship between diet during pregnancy, lactation, or the first year of life suggests that maternal ingestion of probiotic and fish oil supplementation may reduce risk of eczema and allergic sensitization to food, respectively.

Using the

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