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Diagnosing Neuropsychiatric SLE (5.23.2025)

Dr. Jack Cush reviews the news and journal reports from RheumNow.com - including views on the vagus nerve, NPSLE and CAR-T mania.

Hydroxychloroquine for Everyone

Nearly 25 years ago, while lecturing on best therapies for rheumatoid arthritis (RA), I loudly stated that hydroxychloroquine was “useless” and, deservedly, I was “boo-ed” off stage.

Vitamin D Headlines (5.9.2025)

Dr. Jack Cush reviews the news, journal reports and lupus highlights from the past week on RheumNow.com. Triple positivity, the gut and CRPS, and hope for better outcomes with Vitamin D therapy. 

D-Lay Trial: High-Dose Vitamin D Retards Multiple Sclerosis

A randomized clinical trial with oral high-dose cholecalciferol ( vitamin D3) was shown to prevent or delay the onset of clinically isolated syndrome (CIS), typical for multiple sclerosis (MS).

Keys to Mastery (5.2.2025)

Dr. Jack Cush reviews the news, articles and drug approvals from the past week on RheumNow.com. This podcast marks the beginning of our Lupus Campaign called "Lupus Unlocked: Keys to Mastery". This month's campaign on Lupus is sponsored by Aurinia.

EULAR Guidelines on Reproductive Health

MedPage Today
  • Many rheumatologic conditions such as rheumatoid arthritis and lupus often strike women during their reproductive years, with drugs being the primary therapies.
  • Experts assembled by EULAR determined that most of the common medi

Rheumatology: Believe It or Not (4/25/2025)

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Should we believe the reviews and metanalyses?

EMR Messaging Woes (4.11.2025)

Dr. Jack Cush reviews the news, journal reports and regulatory approvals from this past week on RheumNow.com

Autoimmune Disease Impact Report

Integrated Benefit Institute, a nonprofit independent research organization, has published its 2025 Autoimmune Disease Impact Report, which examines the health and productivity impacts of five prevalent and costly autoimmune conditions: rheumatoid arthritis, multiple sclerosis, inflammat

ERA, APPs, & Alpha GAL (3.21.2025)

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.  Listen in for 2 new case questions - Ask Cush Anything.

2024 Rheumatology Year in Review

2024 was a year of surprising new growth in technology, with the expansion of new therapeutic options for many patients and clinicians.  While these many advances offer new hope, they are countered by disappointments and gapping unmet needs in rheumatology. Below is my top 10 list

Hydroxychloro-King (3.7.2025)

Dr. Jack Cush reviews the news, journal reports and regulatory actions from the past week on RheumNow.com

Social

Psychological Bulletin has published that invalidating (gaslighting) pts Sxs can have harmful consequences. Includes pts dx w/ Ehlers-Danlos, endometriosis, fibromyalgia, ME/CFS, POTS, Gulf War, IBS, long Covid, multiple chemical sensitivity, SLE, and vulvodynia.

Dr. John Cush @RheumNow ( View Tweet )

18 hours 45 minutes ago
Belimumab in SLE with Mucocutaneous or Vasculitis Findings A post hoc analysis of a belimumab (BEL) inn systemic lupus erythematosus (SLE) study showed lupus mucocutaneous and vasculitic manifestations improve with BEL and standard care. https://t.co/BlYWKLJPdb

Dr. John Cush @RheumNow ( View Tweet )

2 days 17 hours ago
🔺CTD-ILD radiological signs to look out for 👀 #CTD #ILD #UIP #NSIP #Fibrosis #scleroderma #systemicsclerosis #Sjogrens #Lupus By @IlliasulK https://t.co/hHupTz0bCy
Dr Gurdeep S Dulay @gurdeep_dulay ( View Tweet )
1 week ago
Shifting the Management Paradigm for SLE and Lupus Nephritis The paradigm for treating patients with systemic lupus erythematosus (SLE) is rapidly shifting and our patients will surely benefit with improved outcomes. https://t.co/idxMBTyTwp https://t.co/unxmjVst3D
Dr. John Cush @RheumNow ( View Tweet )
1 week ago
Single center study of 1538 #SLE pts found 2.2% w/ lupus mesenteric vasculitis (LMV) - 39 LMV episodes in 31 pts - 2/3 had Nausea, vomiting, diarrhea & abdominal pain (~15% peritoneal irritation) & had active Dz (renal, Skin, Heme). LMV responded to steroids & https://t.co/AkuvCl6nG6
Dr. John Cush @RheumNow ( View Tweet )
1 week ago
>200 genes 🧬 implicated in #SLE Complex indeed! And ▶️ 7 clusters of signalling pathways So we have to have many Rx options Ab patterns vary LN flares can have v diff pathways between Pts #LUPUS2025 @RheumNow Unravelling #LUPUS2026 https://t.co/LEKN363194
1 week 5 days ago
Monitoring for #HCQ #retinal #toxicity 2 tests beyond visual fields are better than 1 OCT Etc But suggestion if low risk to do only every 5 yrs I don’t agree as risk ⬆️ w disease duration We do Annual fields and either OCT or retinal photography #LUPUS2025 @RheumNow https://t.co/TdPJ47jYEL
1 week 5 days ago
Who does worse with #SLE #nature vs #nurture South American #lupus #registries ⬆️ activity ⬆️damage ⬇️age ⬇️SES ⬆️SLE #antibodies #Gladel registry and others vs Europe Environment >genetics 🤔 #LUPUS2025 #45poster @RheumNow @gponsestel https://t.co/XjiXHAMuGm
1 week 5 days ago
#Proteinuria that persists in #LN #lupus #nephritis even w mild proteinuria 👇 Worse outcomes Just like all CKD Take home Aim for None or minimal in #SLE <150 protein #voclosporin >> PBO (SoC) 1/2 Voclosporin had deep response at least once > PBO #LUPUS2025 @RheumNow https://t.co/CBUzyBatBh
1 week 5 days ago
Refractory Renal SLE How to manage class III/IV lupus glomerulonephritis when you run out of options, by Dr. Jack Cush. https://t.co/syOVCEozfA https://t.co/UOY8MkZeX2
Dr. John Cush @RheumNow ( View Tweet )
2 weeks 6 days ago
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