Articles By Jack Cush, MD
The RheumNow Week in Review - 12 January 2018
Dr. Jack Cush reviews a dozen highlights from the past week on RheumNow.com.
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B Cell Changes Predict Autoimmunity with Checkpoint Inhibitors
The Journal of Clinical Investigation reports results of a study showing that increases in CD21lo B cells and plasmablasts following that combination checkpoint blockade preceded the onset of immune-related adverse events.While some have postulated that IRAEs are thought to be T cell mediated, B cells have also been implicated. Investigators studied 39 melanoma patients undergoing treatment with either anti-CTLA4 or anti-PD1, or combination CCB therapy. They analyzed changes in circulating B cells before and after the first cycle of therapy of immune checkpoint blockade (23 received combination therapy, 8 received anti-CTLA4, and 8 received anti-PD1).
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Ibuprofen’s Anti-androgenic Effect May Result in Hypogonadism in Males
PNAS reports use of ibuprofen by males may result in antiandrogen effects that may contribute to adult male reproductive problems.
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40% of Arthritis Patients Fail to Receive Exercise Guidance
The latest issue of CDC’s MMWR reports that exercise counseling among arthritis patients increased from 52% to 61% (2002 to 2014); hence ~40% do not receive health care provider counseling, suggesting the need for provider education and training in exercise counseling, and improved electroni
Read ArticleIncreasing Adverse Events Seen with Higher Disease Activity in Early RA
Researchers in the NEO-RACo Study Group studied adverse events (AEs) in relation to disease activity in patients with early rheumatoid arthritis (RA).
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Calcium and Vitamin D Supplements Do Not Reduce Hip Fractures
Recent JAMA study shows metanalysis of 33 clinical trials and 51,145 participants, showed that calcium, vitamin D, or both affords no decreased risk of hip fractures compared with placebo or no treatment and therefore questions their routine widespread use in the elderly..
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The RheumNow Week in Review - 5 January 2018
Dr Jack Cush reviews the news and journal articles from the past week on RheumNow.com.
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Malcolm Gladwell Weighs in on Humanizing Doctors Through Aesthetic Interests
Malcolm Gladwell (along with coauthor David Epstein) is well known for his national bestsellers The Tipping Point, Blink, and Out¬liers; all addressing the psychosociologic side of human behaviors and trends.
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Sorting Out the Complexities of Autoimmunity with Immune Checkpoint Inhibitor Therapy
An editorial and systematic review of complications seen when checkpoint inhibitor (CPI) therapies are given to patients with immune mediated inflammatory disorders (IMIDs) and cancer shows that nearly 75% manifest autoimmune and inflammatory immune-related adverse events (irAEs).
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Community Screening for Fracture Risk in Older Women is Effective and Feasible
A UK Study published in Lancet shows that community-based screening programme for fracture risk in older women is feasible, and may reduce hip fractures.
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