Articles By Jack Cush, MD
Tocilizumab in Pregnancy
Tocilizumab is currently listed as a Category "C" pregnancy risk based on limited pre-clinical (animal) data that was negative.
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The Brooklyn HAQ
The Health Assessment Questionnaire is a utilitarian outcome measure, often used in clinical trials and daily practice. Unless you’re still prescribing penacillamine, never attended an ACR meeting, and never read an RA clinical trial, you’re quite familiar with the HAQ and its use in practice. So, surely you’ve heard of the “Brooklyn HAQ”?
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Cancer Risk Lower with TNF inhibitors in Rheumatoid Arthritis
Since the introduction of TNF inhibitors nearly 20 years ago, concerns over a potential associated cancer risk have abounded. The recent ACR RA treatment guidelines have addressed this recently, stating that patients with any solid tumor cancer or risk thereof should be treated as if they ha
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Biologics and Fatigue in Rheumatoid Arthritis
Researchers from Bristol, UK have published a Cochrane review studying the effects of biologic therapies on fatigue.
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Hyperuricemia Increases Risk of Diabetes, Death and CV Disorders in Hypertensive Patients
While hyperuricemia is linked to gout and many of the elements that make up the metabolic syndrome, it's not so clear that hyperuricemia is an independant risk factor for hypertension, diabetes, cardiovascular outcomes, etc.
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RheumNow Week in Review – 24 June 2016
Dr. Cush reviews highlights published this week at RheumNow.com.
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Infection Risk Increased in Giant Cell Arteritis
French researchers recruited 486 patients with giant cell arteritis (GCA) from over 40 centers throughout France, and compared their outcomes to age and sex matched individuals randomly selected from the general population. Both groups were followed for 5 years and assessed for the risk of serious infections.
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Hypogonadism Ups the Risk of Autoimmunity
In a variety of models, testosterone has been shown to be immunosuppressive and deficiency of testosterone has been linked with autoimmune disease and increases in C-reactive protein (CRP), tumor necrosis factor, and interleukin-6 (IL-6).
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Predictors of Progression in Early Inflammatory Polyarthritis
A substantial, but unclear, percentage of patients presenting with new onset inflammatory polyarthritis (IP) will spontaneously remit, while others may persist and develop rheumatoid arthritis (RA).
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