Articles By Jack Cush, MD
Rheumatology - the Favored Few
A routine visit, followed by a few post-visit comments from the familly, is all it takes to remind me how great it is to be a rheumatologist.
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Off-Label Use – A Free Speech, Scientific and Safety Issue
Is off-label drug use an example of "free speech"? Do off-label use guidelines affect every day practice or the way Pharma promotes its product outside of the indications for which it was approved?
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Epidural Steroid Injections Ineffective
A meta-analysis of 30 placebo-controlled trials evaluated epidural corticosteroid injections for radiculopathy, and 8 trials were done for spinal stenosis.
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Colon Cancer Risk Cut by Aspirin and NSAIDs
A population-based study from Northern Denmark studied the effects of aspirin and NSAIDs on colorectal cancer rates (Citation source http://buff.ly/1KJQ6H3).
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Secukinumab Bests Ustekinumab in Psoriasis CLEAR Study
The CLEAR study was a one-year, randomized, double-blind trial compared subcutaneous standard doses of secukinumab (anti-IL17) and ustekinumab (anti-IL12/23) in patients with moderate-severe plaque psoriasis.
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Amgen Agrees to $71 Million Settlement over Enbrel & Aranesp Promotion
Based on potentiallly off-label promotion of blockbuster drugs Aranesp and Enbrel, Amgen has agreed to a $71 million settlement with 48 states and the District of Columbia.
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Serious Infections are Increasing in Lupus
Tektonidou and coworkers have analyzed hospitalized serious infections (SIE) involving lupus patients over a 15 year period and show that SIE in SLE have increased substantially between 1996 and 2011, and in 2011 are 12 times higher than seen in patients without SLE.
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Poor Compliance in SLE Leads to More ER Visits and Hospitalizations
Feldman and coworkers have analyzed US Medicaid claims data from 9,600 hydroxychloroquine and 3,829 new immunosuppressive new users with a diagnosis of SLE.
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"Eye of Newt" Leads Regenerative Therapy in Osteoarthritis
Regeneration of cartilage is the holy grail of osteoarthritis research.
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Enthesitis Ultrasound as an Outcome Measure in Spondyloarthritis
Musculoskeletal ultrasound (US) was recently used in a longitudinal study Achilles enthesis of 146 patients with early spondyloarthritis (SpA). Usual measures of SpA activity included BASFI, BASRI-spine, BASDAI and Ankylosing Spondylitis Disease Activity Score (ASDAS).
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