Secukinumab Bests Ustekinumab in Psoriasis CLEAR Study

The CLEAR study was a one-year, randomized, double-blind trial compared subcutaneous standard doses of secukinumab (anti-IL17) and ustekinumab (anti-IL12/23) in patients with moderate-severe plaque psoriasis.  

Using the highest benchmark (PASI-90) as the primary endpoint, secukinumab (79.0%) was superior to ustekinumab (57.6%) at week 16. Even at the week 4 time point, secukinumab had better PASI-75 outcomes than ustekinumab (50.0% versus 20.6%). Safety outcomes were similar, there were no deaths and serious adverse events only affected 3% of each group. 

Such head-to-head trials will be pivotal to patients and physicians in managing moderate to severe psoriasis.

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Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe plaque psoriasis: CLEAR, a randomize

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The author has no conflicts of interest to disclose related to this subject
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