Articles By Jack Cush, MD
DRESS Trial Shows TNFi Dose Reduction is Possible - Without Major Flares
Can TNF inhibitor therapy be withdrawn in RA patients who are in remission? The DRESS trial reports the results of randomized trial of 180 RA patients taking either etanercept or adalimumab. Patients were randomly assigned to either usual care (no dose reduction) or a stepwise increase
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May is Arthritis Awareness Month
May is Arthritis Awareness Month. Arthritis affects an estimated 52.5 million U.S. adults, is a common comorbidity among those with multiple chronic conditions, and is a leading cause of disability in the United States.
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Diet, Exercise and Glucosamine Fail to Prevent OA in Overweight Females
An at-risk population of 407 middle-aged overweight women (BMI ≥ 27 kg/m2) without clinical signs of knee osteoarthritis were prospectively studied for 2.5 years and randomized to receive either glucosamine or diet and exercise in a double-blind, placebo-controlled trial.
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Calprotectin as a Biomarker in RA
Calprotectin a major S100 protein, produced by leukocytes is a potential new biomarker for use as it may be more sensitive disease activity changes than conventional acute-phase proteins.
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Chronobiology: When Will It's Time Come?
Morning stiffness is a historic feature of RA and may be related to prolonged inactivity or the chronobiology of rheumatoid inflammation. Chronobiology and chronopharmacology are receiving consideration in investigation and RA trial design. Researchers from Maynooth, Berlin, Vienna and
Read ArticleHot Stuff from the Cleveland Clinic Biologic Therapies Summit – Part I
Highlights and take-home messages from the Cleveland Clinic Center for Continuing Education's Biologic Therapies Summit held this week (April 30 – May 2, 2015).
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Daily Aspirin Taken by More Than Half of Older U.S. Adults
Despite guidelines stating that low dose aspirin is indicated for secondary prevention of MI and stroke, a recent survey shows that over half of US adults take daily low dose aspirin.
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Review of Bisphosphonates and Atypical femoral fractures
The Journal For Nurse Practitioners provides a succinct overview of atypical femoral fractures and bisphosphonates. These popular agents account for 14 million prescriptions annually in the United States.
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Lyme disease: recent advances and perspectives
Lyme disease remains endemic in many parts of North America and continues as a public health concern. This article reviews endemic and nonedemic areas, the lack of an available Lyme vaccine, immune pathways and what is known about the vector and bug.
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HLA-DRB1 Alleles Augment RA Severity and TNF Inhibitor Responses
The HLA-DRB1 haplotype is a known risk factor for RA.
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