Cal, Thats story is a blast from the past and one that lead to a major redesign in how we do RA trials. The born again thing caused unblinding that since resulted in the need for 2 MD's to run the trial - the "blinded" doc who would come in and do the exam and global assessment based on the exam ("DONT TALK TO THE PATIENT!!") and what we at UT Southwestern called the "Toxic" doc - the one who saw all the data and assessed the labs and safety issues. Nevertheless; as you point out this phenomenon lead to the need for a blinded assessor - a practice still in evidence today, although if its not a TNF inhibitor, Im not sure how the doctor would be unblinded. Great recall!