Thanks Dr Pope for practical tips. How about this scenario (not unlikely): mild to moderate lupus in good control with Plaquenil for years. Patient is now older (50,60ish..), and nervous about vision side effect. With agreement, patient goes off Plaquenil. She continues to be in remission for a few years, then active lupus recurs, requiring resumption of Plaquenil (same dose): Question: do we start the same monitoring program (ie baseline then annually after 5 years, or annually after baseline. Without any study about this, I probably would do annual check to be on the safe side