FDA approved  romosozumab .it inhibits sclerostin .as all of us know, physiologically sclerostin inhibits WNT signaling pathway. Physiologically WNT signaling pathway leads to increased bone formation.now when we inhibit sclerostin to treat osteoporosis,inhibition of WNT signaling pathway will be removed that leads to increased bone formation and it will be worsen osteophyte formation  in osteoarthritic patients...