The GI literature is growing with the suggestion that IL-6 is the next cytokine in Crohn's Disease. The question I have had to come to terms with is when it is seen in younger patients 40 yo) and whether this is Takayasu's or Aortitis unique to CD. As such is this an extra-intestinal manifestation that might parallel the bowel (e.g. Type I Peripheral arthritis) or march on independent of the bowel (e.g spondylitis).