I very much appreciate Dr. West's comments on our study. In the study in ARD, we focused on kit variability. Ongoing studies are investigating possible determinants of any change in ANA status during the course of disease, recognizing potential differences among kits in ANA detection. We are very interested in those patients who become consistently ANA negative and, like Dr. West, wonder whether they still have SLE or should be in trials. The phenomenon of ANA negativity has not been well studied but is definitely worth attention as interest in remission in SLE grows.