Thanks Joel. Your wisdom and insight here is certainly appreciated by all. There are clearly short comings to this data and its kind. I posted it because since your report there hasnt been any detailed look at alcohol intake with MTX use from a large cohort and thus I thought it would be good to revisit this issue and bring up what was previously done. I do believe there is some value in showing that low/moderate EtOH use was not associated with >3x elevations of LFTs - less may not have impressed or been meaningful. I admit we dont know the long term or tissue consequences of the EtOH intake or LFT elevations referenced but who will ever get us such data? Arent we still operating in a vacumn of limited information? I would really like more information to know what to tell my patient, since I long ago gave up on "no alcohol" and "dont dring more than your rheumatologist". JJC