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Robert Shmerling

| Apr 20, 2016 5:28 pm

The "headline" here ("HLA-B*5801 Testing Needed in Asians and Blacks with Gout") is NOT what the authors of this study concluded; they concluded "these findings support the use of vigilance in these minorities when considering allopurinol." And, while the relative risks looks concerning, the very low rates of SJS/TEN with allopurinol do not necessarily warrant routine screening every patient of African American or Asian descent. We would need a cost analysis to know whether it makes sense; do we know how much HLA-B*5801 testing costs? Also, this study noted that "the US Japanese population has a low allele frequency of HLA-B*5801 (0.8%)...similar to US Whites as well as the Japanese population of Japan (0.6%) .... we expect a risk level similar to that of Whites' - so, again, the study does not support the headline as stated.