Jack, re statement that scMTX results in incr toxicity, you may find the publication from the CATCH cohort to be of interest as improved durability is demonstrated w scMTX Hazlewood GS, Thorne JC, Pope JE, Lin D, Tin D, Boire G, et al. The comparative effectiveness of oral versus subcutaneous methotrexate for the treatment of early rheumatoid arthritis. Ann Rheum Dis. 2015 May 15.